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• W4313389706 abstract "Lysophosphatidic acid (LPA) and geminin are overexpressed in ovarian cancer, and increasing evidence supports their contribution to ovarian tumor development. Here, we reveal that geminin depletion induces autophagy suppression and enhances reactive oxygen species (ROS) production and apoptosis of high-grade serous ovarian cancer (HGSOC) cells. Bioinformatics analysis and pharmacological inhibition studies confirm that LPA activates geminin expression in the early S phase in HGSOC cells via the LPAR 1/3 /MMPs/EGFR/PI3K/mTOR pathway. Furthermore, LPA phosphorylates Aurora-A kinase on Thr288 through EGFR transactivation, and this event potentiates additional geminin stabilization. In turn, overexpressed and stabilized geminin regulates DNA replication, cell-cycle progression, and cell proliferation of HGSOC cells. Our data provide potential targets for enhancing the clinical benefit of HGSOC precision medicine." @default.
• W4313389706 created "2023-01-06" @default.
• W4313389706 creator A5039349365 @default.
• W4313389706 creator A5044734793 @default.
• W4313389706 creator A5045268311 @default.
• W4313389706 creator A5063715240 @default.
• W4313389706 creator A5072945170 @default.
• W4313389706 creator A5076972581 @default.
• W4313389706 creator A5078713137 @default.
• W4313389706 date "2022-12-19" @default.
• W4313389706 modified "2023-09-30" @default.
• W4313389706 title "Lysophosphatidic acid suppresses apoptosis of high-grade serous ovarian cancer cells by inducing autophagy activity and promotes cell-cycle progression via EGFR-PI3K/Aurora-AThr288-geminin dual signaling pathways" @default.
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