FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313391907> ?p ?o ?g. }

• W4313391907 endingPage "14" @default.
• W4313391907 startingPage "1" @default.
• W4313391907 abstract "Monkeypox is a viral zoonotic disease, often transmitted to humans from animals. While the whole world is haggling with the COVID-19 pandemic, the emergence of the monkeypox virus (MPXV) arose as a new challenge to mankind. Till date, numerous cases related to the MPXV have been reported in several countries across the globe, but, its momentary distribution in the current time has left everyone in fright with increasing mortality and limited clinically approved treatments. Therefore, it is of immense importance to develop a potent and highly effective vaccine capable of inducing desired immunogenic responses against the highly contagious MPXV. Herein, using various immunoinformatic and computational biology tools, we made an attempt to develop a multi-epitope vaccine construct against the MPXV which is antigenic, non-allergen and non-toxic in nature and capable of exhibiting immunogenic behavior. The sequence of vaccine construct was designed using the proposed 4 MHC-I, 3 MHC-II and 4 B-cell epitopes linked with suitable adjuvant and linkers. The modeled structure of the vaccine construct was used to assess its interaction with the Toll-like Receptor 4 (TLR4) using ClusPro and HADDOCK. All-atoms molecular dynamics simulation of the MPXV vaccine construct-TLR4 complex followed by a high level of gene expression of the construct within the bacterial system affirmed its stability along with induction of immunogenic response within the host cell. Altogether, our immunoinformatic approach aid in the development of a stable chimeric vaccine construct against MPXV and needs further experimental validation for its immunological relevance and usefulness as a vaccine candidate.Communicated by Ramaswamy H. Sarma." @default.
• W4313391907 created "2023-01-06" @default.
• W4313391907 creator A5005137018 @default.
• W4313391907 creator A5017586743 @default.
• W4313391907 creator A5024972924 @default.
• W4313391907 creator A5052560870 @default.
• W4313391907 creator A5055211583 @default.
• W4313391907 creator A5061858117 @default.
• W4313391907 creator A5076728587 @default.
• W4313391907 date "2023-01-02" @default.
• W4313391907 modified "2023-10-16" @default.
• W4313391907 title "An immunoinformatic approach towards development of a potent and effective multi-epitope vaccine against monkeypox virus (MPXV)" @default.
• W4313391907 cites W1031578623 @default.
• W4313391907 cites W1527680652 @default.
• W4313391907 cites W1975459052 @default.
• W4313391907 cites W1982539402 @default.
• W4313391907 cites W1985956244 @default.
• W4313391907 cites W1986191025 @default.
• W4313391907 cites W1993667370 @default.
• W4313391907 cites W2012400135 @default.
• W4313391907 cites W2014274241 @default.
• W4313391907 cites W2015176909 @default.
• W4313391907 cites W2019711015 @default.
• W4313391907 cites W2021258915 @default.
• W4313391907 cites W2029667189 @default.
• W4313391907 cites W2031215290 @default.
• W4313391907 cites W2051381895 @default.
• W4313391907 cites W2066609648 @default.
• W4313391907 cites W2071486470 @default.
• W4313391907 cites W2075364188 @default.
• W4313391907 cites W2082835279 @default.
• W4313391907 cites W2093221728 @default.
• W4313391907 cites W2095805596 @default.
• W4313391907 cites W2097202840 @default.
• W4313391907 cites W2102367710 @default.
• W4313391907 cites W2102993309 @default.
• W4313391907 cites W2115167726 @default.
• W4313391907 cites W2116963147 @default.
• W4313391907 cites W2130655121 @default.
• W4313391907 cites W2135143264 @default.
• W4313391907 cites W2143397050 @default.
• W4313391907 cites W2154019529 @default.
• W4313391907 cites W2155151751 @default.
• W4313391907 cites W2165779834 @default.
• W4313391907 cites W2168036974 @default.
• W4313391907 cites W2168688111 @default.
• W4313391907 cites W2301868282 @default.
• W4313391907 cites W2339647820 @default.
• W4313391907 cites W2343931134 @default.
• W4313391907 cites W2346971907 @default.
• W4313391907 cites W2560808197 @default.
• W4313391907 cites W2572080171 @default.
• W4313391907 cites W2597298689 @default.
• W4313391907 cites W2608086803 @default.
• W4313391907 cites W2611314002 @default.
• W4313391907 cites W2620185010 @default.
• W4313391907 cites W2624284467 @default.
• W4313391907 cites W2806769367 @default.
• W4313391907 cites W2891488137 @default.
• W4313391907 cites W2892113269 @default.
• W4313391907 cites W2898389621 @default.
• W4313391907 cites W2909455948 @default.
• W4313391907 cites W2918075940 @default.
• W4313391907 cites W2948216320 @default.
• W4313391907 cites W2953452250 @default.
• W4313391907 cites W2955071890 @default.
• W4313391907 cites W3022974266 @default.
• W4313391907 cites W3039821298 @default.
• W4313391907 cites W3047616897 @default.
• W4313391907 cites W3080551473 @default.
• W4313391907 cites W3115254893 @default.
• W4313391907 cites W3118624523 @default.
• W4313391907 cites W3123558836 @default.
• W4313391907 cites W3185197558 @default.
• W4313391907 cites W3186179742 @default.
• W4313391907 cites W3190559572 @default.
• W4313391907 cites W3195434743 @default.
• W4313391907 cites W3195990348 @default.
• W4313391907 cites W3204868409 @default.
• W4313391907 cites W4206908870 @default.
• W4313391907 cites W4211060053 @default.
• W4313391907 cites W4244736178 @default.
• W4313391907 cites W4246356731 @default.
• W4313391907 cites W4281893638 @default.
• W4313391907 cites W4282913866 @default.
• W4313391907 cites W4283771170 @default.
• W4313391907 cites W4286383196 @default.
• W4313391907 cites W4289274885 @default.
• W4313391907 cites W4291019715 @default.
• W4313391907 cites W4293018150 @default.
• W4313391907 cites W4296757993 @default.
• W4313391907 cites W4297058944 @default.
• W4313391907 cites W4303649511 @default.
• W4313391907 doi "https://doi.org/10.1080/07391102.2022.2163426" @default.
• W4313391907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36591724" @default.
• W4313391907 hasPublicationYear "2023" @default.
• W4313391907 type Work @default.
• W4313391907 citedByCount "1" @default.

• next