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• W4313391937 endingPage "700" @default.
• W4313391937 startingPage "700" @default.
• W4313391937 abstract "Migraine is a chronic neurological disorder that affects approximately 12% of the population. The cause of migraine headaches is not yet known, however, when the trigeminal system is activated, neuropeptides such as calcitonin gene-related peptide (CGRP) and substance P (SP) are released, which cause neurogenic inflammation and sensitization. Advances in the understanding of migraine pathophysiology have identified new potential pharmacological targets. In recent years, transient receptor potential (TRP) channels have been the focus of attention in the pathophysiology of various pain disorders, including primary headaches. Genetic and pharmacological data suggest the role of TRP channels in pain sensation and the activation and sensitization of dural afferents. In addition, TRP channels are widely expressed in the trigeminal system and brain regions which are associated with the pathophysiology of migraine and furthermore, co-localize several neuropeptides that are implicated in the development of migraine attacks. Moreover, there are several migraine trigger agents known to activate TRP channels. Based on these, TRP channels have an essential role in migraine pain and associated symptoms, such as hyperalgesia and allodynia. In this review, we discuss the role of the certain TRP channels in migraine pathophysiology and their therapeutic applicability." @default.
• W4313391937 created "2023-01-06" @default.
• W4313391937 creator A5008195533 @default.
• W4313391937 creator A5035093314 @default.
• W4313391937 creator A5071179672 @default.
• W4313391937 date "2022-12-31" @default.
• W4313391937 modified "2023-09-30" @default.
• W4313391937 title "TRP Channels: Recent Development in Translational Research and Potential Therapeutic Targets in Migraine" @default.
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