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• W4313392916 abstract "Purpose: The aim of this retrospective study is to compare the results of MRI-TRUS fusion targeted and systematic prostate biopsy (TSPB) versus conventional systematic prostate biopsy (SPB), in biopsy naïve patients with available MRI results at time of biopsy. Between January 1, 2018, and May 31, 2022, patients with Materials And Methods: clinical suspicion of prostate cancer based on abnormal PSA level and/or abnormal Digital Rectal Exam (DRE) who were scheduled for prostate biopsy, were included. All patients had undergone multiparametric (mp) MRI before biopsy, and the results of this scan were known to the urologist performing the biopsy. Patients were classied according to whether they had undergone MRI-TRUS fusion targeted + systematic biopsies (TSPB, group 1) or standard TRUS systematic biopsies (SPB, group 2). We compared cancer detection rate (CDR), clinically signicant cancer (ISUP≥2) detection rate, rate of upgrading or downgrading in radical prostatectomy treatment group and prostate biopsy complications. Results: There was no statistically signicant difference in global CDR between group 1 (TSPB) and group 2 (SPB), CDR 59.7% (43/72) and 54.8% (102/186), (p< 0.48), respectively. Prostate cancer prevalence was 56.2% (145/258). There was 3 times higher risk of PCa detection in patients with MRI-visible lesions comparable to those with no MRI-visible lesions, CDR 66% (110/166 patients), and 38% (35/92 patients), OR 3.2 CI [1.9-5.4], (p<0.001), respectively. Rates of upgrading and downgrading on whole-mount histopathological analysis were 23.5% and 17.6% respectively. There was no increased risk of complications rates post prostate biopsy in both groups. In this single centre Conclusion: retrospective study we found no differences in CDR across combined MRI-TRUS fusion + systematic prostate biopsies versus systematic prostate biopsies in men having undergone mpMRI. Knowledge of the anatomical location of the index lesion may benet CDR in patients undergoing standard systematic biopsies. Our study investigated the results of pros Patient summary: tate biopsy strategy in patients suspected of having prostate cancer based on their abnormal PSA level and/or DRE. The results showed that there was no signicant difference between the prostate biopsies done systematically or those done using MRI-TRUS fusion (targeted and systematic) even when there is MRI-visible lesion." @default.
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• W4313392916 date "2022-12-01" @default.
• W4313392916 modified "2023-09-30" @default.
• W4313392916 title "SINGLE CENTRE RETROSPECTIVE STUDY COMPARING MAGNETIC RESONANCE-TRANSRECTAL ULTRASOUND (TRUS) FUSION TARGETED AND SYSTEMATIC BIOPSY VERSUS CONVENTIONAL TRUS SYSTEMATIC BIOPSY FOR DETECTING PROSTATE CANCER" @default.
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• W4313392916 doi "https://doi.org/10.36106/ijar/4917020" @default.
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