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- W4313393732 abstract "Summary Administration of dinitrophenyl-ovalbumin to newborn guinea pigs resulted in the specific suppression of delayed hypersensitivity to this antigen after immunization with the same antigen in complete adjuvant in about half of the animals. The duration of the suppression of delayed hypersensitivity appears to be related to the dose of antigen administered in the 1st week of life. Delayed hypersensitivity was successfully transferred with sensitized lymph node cells to recipient animals which had been rendered “partially tolerant.” Complement-fixing but not passive cutaneous anaphylaxis (PCA) antibody were also suppressed at 6 and 8 weeks of age in about half of the animals injected neonatally with a large dose of antigen. A similar state of “partial unresponsiveness” was obtained in adult animals, although under these experimental conditions, larger amounts of antigen appear to be necessary. No correlation was found between the suppression of delayed hypersensitivity and the formation of γ1 (PCA) and complement-fixing antibody. These data support the assumption that the various immune phenomena evolve independently of each other. Some biologic implications of a state of “partial unresponsiveness” are discussed." @default.
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- W4313393732 date "1967-05-01" @default.
- W4313393732 modified "2023-09-23" @default.
- W4313393732 title "Dissociation of Immune Responses by the Induction of Partial Unresponsiveness" @default.
- W4313393732 doi "https://doi.org/10.4049/jimmunol.98.5.881" @default.
- W4313393732 hasPublicationYear "1967" @default.
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