Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313394589> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4313394589 endingPage "56" @default.
- W4313394589 startingPage "52" @default.
- W4313394589 abstract "Neurodegenerative disorders including Alzheimer's disease (AD) and Parkinson's disease (PD) are hard to treat once they have suffered. Therefore, the establishment of new prevention and treatment methods for neurodegenerative disorders is an urgent issue for Japan's aging society, from the perspective of improving the quality of life of patients and medical staff involved in their care. Human induced pluripotent stem cells (hiPSCs) have contributed to the understanding of the pathology of neurodegenerative diseases, and to the development of new preventive and therapeutic strategies based on the understanding of human diseases. Furthermore, new cross-disciplinary scientific trends together with iPSC technology are emerging in the fields of life science, medical science, and information technology. The fusion of various research knowledges and technologies may provide new scientific progress for better understanding of molecular mechanisms of pathology and the onset of neurodegenerative diseases. Here we have developed new brain model with hiPSC technology for the understanding of pathology of AD and PD based on the induction of region-specific brain organoids and microglia using hiPSCs. These brain organoids technology enables us to provide simpler and reproducible analytical methods by combining with not only developmental biology and pharmacology but also transcriptome analysis and direct conversion. These technological advantages contribute to the creation of new research fields with human brain research to understand higher brain functions and pathophysiology of neurodegenerative diseases such as AD and PD." @default.
- W4313394589 created "2023-01-06" @default.
- W4313394589 creator A5011900319 @default.
- W4313394589 creator A5032064265 @default.
- W4313394589 date "2023-01-01" @default.
- W4313394589 modified "2023-09-27" @default.
- W4313394589 title "Disease modeling using human induced pluripotent stem cell-derived microglia and region-specific neurons" @default.
- W4313394589 cites W2000399153 @default.
- W4313394589 cites W2031365272 @default.
- W4313394589 cites W2087786585 @default.
- W4313394589 cites W2103705124 @default.
- W4313394589 cites W2128940002 @default.
- W4313394589 cites W2139976280 @default.
- W4313394589 cites W2146890924 @default.
- W4313394589 cites W2148898943 @default.
- W4313394589 cites W2528543174 @default.
- W4313394589 cites W2569935680 @default.
- W4313394589 cites W2622807556 @default.
- W4313394589 cites W2736895630 @default.
- W4313394589 cites W2769606714 @default.
- W4313394589 cites W2796013529 @default.
- W4313394589 cites W2885306088 @default.
- W4313394589 cites W2942678593 @default.
- W4313394589 cites W2982368706 @default.
- W4313394589 cites W3087016663 @default.
- W4313394589 cites W3128463973 @default.
- W4313394589 cites W3193241339 @default.
- W4313394589 cites W3198245230 @default.
- W4313394589 cites W3200461021 @default.
- W4313394589 cites W4223922908 @default.
- W4313394589 cites W4224214693 @default.
- W4313394589 doi "https://doi.org/10.1254/fpj.22087" @default.
- W4313394589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36596492" @default.
- W4313394589 hasPublicationYear "2023" @default.
- W4313394589 type Work @default.
- W4313394589 citedByCount "0" @default.
- W4313394589 crossrefType "journal-article" @default.
- W4313394589 hasAuthorship W4313394589A5011900319 @default.
- W4313394589 hasAuthorship W4313394589A5032064265 @default.
- W4313394589 hasConcept C104317684 @default.
- W4313394589 hasConcept C107459253 @default.
- W4313394589 hasConcept C142724271 @default.
- W4313394589 hasConcept C145103041 @default.
- W4313394589 hasConcept C169760540 @default.
- W4313394589 hasConcept C203014093 @default.
- W4313394589 hasConcept C2776914184 @default.
- W4313394589 hasConcept C2777670902 @default.
- W4313394589 hasConcept C2779134260 @default.
- W4313394589 hasConcept C2779830541 @default.
- W4313394589 hasConcept C2910924664 @default.
- W4313394589 hasConcept C31695470 @default.
- W4313394589 hasConcept C55493867 @default.
- W4313394589 hasConcept C60644358 @default.
- W4313394589 hasConcept C71924100 @default.
- W4313394589 hasConcept C86803240 @default.
- W4313394589 hasConceptScore W4313394589C104317684 @default.
- W4313394589 hasConceptScore W4313394589C107459253 @default.
- W4313394589 hasConceptScore W4313394589C142724271 @default.
- W4313394589 hasConceptScore W4313394589C145103041 @default.
- W4313394589 hasConceptScore W4313394589C169760540 @default.
- W4313394589 hasConceptScore W4313394589C203014093 @default.
- W4313394589 hasConceptScore W4313394589C2776914184 @default.
- W4313394589 hasConceptScore W4313394589C2777670902 @default.
- W4313394589 hasConceptScore W4313394589C2779134260 @default.
- W4313394589 hasConceptScore W4313394589C2779830541 @default.
- W4313394589 hasConceptScore W4313394589C2910924664 @default.
- W4313394589 hasConceptScore W4313394589C31695470 @default.
- W4313394589 hasConceptScore W4313394589C55493867 @default.
- W4313394589 hasConceptScore W4313394589C60644358 @default.
- W4313394589 hasConceptScore W4313394589C71924100 @default.
- W4313394589 hasConceptScore W4313394589C86803240 @default.
- W4313394589 hasIssue "1" @default.
- W4313394589 hasLocation W43133945891 @default.
- W4313394589 hasLocation W43133945892 @default.
- W4313394589 hasOpenAccess W4313394589 @default.
- W4313394589 hasPrimaryLocation W43133945891 @default.
- W4313394589 hasRelatedWork W2075483847 @default.
- W4313394589 hasRelatedWork W2753168648 @default.
- W4313394589 hasRelatedWork W2767281618 @default.
- W4313394589 hasRelatedWork W3015475257 @default.
- W4313394589 hasRelatedWork W3032525775 @default.
- W4313394589 hasRelatedWork W3113821419 @default.
- W4313394589 hasRelatedWork W3131285931 @default.
- W4313394589 hasRelatedWork W3186987912 @default.
- W4313394589 hasRelatedWork W3201538524 @default.
- W4313394589 hasRelatedWork W4210402978 @default.
- W4313394589 hasVolume "158" @default.
- W4313394589 isParatext "false" @default.
- W4313394589 isRetracted "false" @default.
- W4313394589 workType "article" @default.