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• W4313395770 abstract "Abstract Background Non-modifiable risk factors of Alzheimer’s disease (AD) have lifelong effects on cortical integrity that could be mitigated if identified at early stages. However, it remains unknown whether cortical microstructure is affected in older individuals with non-modifiable AD risk factors and whether altered cortical tissue integrity produces abnormalities in brain functional networks in this AD-risk population. Methods Using relative T1w/T2w (rT1w/T2w) ratio maps, we have compared tissue integrity of normal-appearing cortical GM between controls and cognitively normal older adults with either APOE4 ( N = 50), with a first-degree family history (FH) of AD ( N = 52), or with the co-occurrence of both AD risk factors (APOE4+FH) ( N = 35). Additionally, individuals with only one risk factor (APOE4 or FH) were combined into one group ( N = 102) and compared with controls. The same number of controls matched in age, sex, and years of education was employed for each of these comparisons. Group differences in resting state functional connectivity (rs-FC) patterns were also investigated, using as FC seeds those cortical regions showing significant changes in rT1w/T2w ratios. Results Overall, individuals with non-modifiable AD risk factors exhibited significant variations in rT1w/T2w ratios compared to controls, being APOE4 and APOE4+FH at opposite ends of a continuum. The co-occurrence of APOE4 and FH was further accompanied by altered patterns of rs-FC. Conclusions These findings may have practical implications for early detection of cortical abnormalities in older populations with APOE4 and/or FH of AD and open new avenues to monitor changes in cortical tissue integrity associated with non-modifiable AD risk factors." @default.
• W4313395770 created "2023-01-06" @default.
• W4313395770 creator A5025847833 @default.
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• W4313395770 date "2022-12-31" @default.
• W4313395770 modified "2023-10-01" @default.
• W4313395770 title "Effects of non-modifiable risk factors of Alzheimer’s disease on intracortical myelin content" @default.
• W4313395770 cites W1544359545 @default.
• W4313395770 cites W1585653286 @default.
• W4313395770 cites W1649032905 @default.
• W4313395770 cites W1746221723 @default.
• W4313395770 cites W1887151325 @default.
• W4313395770 cites W1967823816 @default.
• W4313395770 cites W1975821649 @default.
• W4313395770 cites W1981027686 @default.
• W4313395770 cites W1983801775 @default.
• W4313395770 cites W2001091274 @default.
• W4313395770 cites W2004284975 @default.
• W4313395770 cites W2011554023 @default.
• W4313395770 cites W2012766927 @default.
• W4313395770 cites W2020044743 @default.
• W4313395770 cites W2025693096 @default.
• W4313395770 cites W2036362108 @default.
• W4313395770 cites W2040434160 @default.
• W4313395770 cites W2067462624 @default.
• W4313395770 cites W2074829442 @default.
• W4313395770 cites W2080503418 @default.
• W4313395770 cites W2081771004 @default.
• W4313395770 cites W2090410452 @default.
• W4313395770 cites W2093195697 @default.
• W4313395770 cites W2094044389 @default.
• W4313395770 cites W2101135654 @default.
• W4313395770 cites W2110208125 @default.
• W4313395770 cites W2113795339 @default.
• W4313395770 cites W2114617955 @default.
• W4313395770 cites W2124770605 @default.
• W4313395770 cites W2126968890 @default.
• W4313395770 cites W2133470640 @default.
• W4313395770 cites W2138092999 @default.
• W4313395770 cites W2139671539 @default.
• W4313395770 cites W2147474139 @default.
• W4313395770 cites W2157257192 @default.
• W4313395770 cites W2159337472 @default.
• W4313395770 cites W2169302269 @default.
• W4313395770 cites W2180449937 @default.
• W4313395770 cites W2273698149 @default.
• W4313395770 cites W2299712320 @default.
• W4313395770 cites W2486213928 @default.
• W4313395770 cites W2512538333 @default.
• W4313395770 cites W2526350827 @default.
• W4313395770 cites W2557837807 @default.
• W4313395770 cites W2563669845 @default.
• W4313395770 cites W2584394395 @default.
• W4313395770 cites W2587061236 @default.
• W4313395770 cites W2607261398 @default.
• W4313395770 cites W2782941668 @default.
• W4313395770 cites W2783800543 @default.
• W4313395770 cites W2784266654 @default.
• W4313395770 cites W2803335432 @default.
• W4313395770 cites W2827807866 @default.
• W4313395770 cites W2832769012 @default.
• W4313395770 cites W2888707262 @default.
• W4313395770 cites W2899869201 @default.
• W4313395770 cites W2900642406 @default.
• W4313395770 cites W2949046211 @default.
• W4313395770 cites W2952299562 @default.
• W4313395770 cites W2952609316 @default.
• W4313395770 cites W2954099113 @default.
• W4313395770 cites W2968377961 @default.
• W4313395770 cites W3010044425 @default.
• W4313395770 cites W3036637121 @default.
• W4313395770 cites W3093601616 @default.
• W4313395770 cites W3098810472 @default.
• W4313395770 cites W3121065829 @default.
• W4313395770 cites W3135230407 @default.
• W4313395770 cites W3162348472 @default.
• W4313395770 cites W3164190639 @default.
• W4313395770 cites W3215846974 @default.
• W4313395770 cites W4205397371 @default.
• W4313395770 cites W4207012705 @default.
• W4313395770 cites W4207032715 @default.
• W4313395770 cites W4226111717 @default.
• W4313395770 cites W4280621002 @default.
• W4313395770 cites W4281954245 @default.
• W4313395770 cites W4282929196 @default.
• W4313395770 cites W4283026616 @default.
• W4313395770 cites W4283786315 @default.
• W4313395770 doi "https://doi.org/10.1186/s13195-022-01152-y" @default.
• W4313395770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36587227" @default.
• W4313395770 hasPublicationYear "2022" @default.
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