Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313395861> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4313395861 endingPage "8" @default.
- W4313395861 startingPage "1" @default.
- W4313395861 abstract "Marine sponges are among the most primitive animals and often contain unique, biologically active compounds. Several of these compounds have played an important roles as pharmaceutical leads for anti-cancer drugs, such as halichondrin B, which led to the development of an anti-breast cancer drug. Some compounds with remarkable biological activities are accumulated in significantly high concentrations in the sponge. How and why the marine sponges produce and accumulate bioactive natural products are long-standing questions with both biochemical and ecological implications, since in sponges, the animal-microbe symbioses are presumed to be responsible for the biosynthetic machinery, consisting of efficient enzymes and regulatory systems for the specific biological activities of medicinally relevant natural products. In this review, I focus on the chemically rich Theonellidae family sponges and discuss the biosynthesis of bioactive peptides and polyketides. In particular, the biosynthetic pathway of calyculin A suggests that crosstalk between the sponge host and bacterial symbiont confers a chemical defense system on the immobile animal-microbe holobiont." @default.
- W4313395861 created "2023-01-06" @default.
- W4313395861 creator A5064472249 @default.
- W4313395861 date "2023-01-01" @default.
- W4313395861 modified "2023-09-30" @default.
- W4313395861 title "Biosynthesis of Bioactive Natural Products Derived from Theonellidae Family Marine Sponges" @default.
- W4313395861 cites W1503066550 @default.
- W4313395861 cites W1960741063 @default.
- W4313395861 cites W1967408138 @default.
- W4313395861 cites W1970064486 @default.
- W4313395861 cites W1973557327 @default.
- W4313395861 cites W1975407624 @default.
- W4313395861 cites W2005750825 @default.
- W4313395861 cites W2007404630 @default.
- W4313395861 cites W2008996705 @default.
- W4313395861 cites W2011757239 @default.
- W4313395861 cites W2015575535 @default.
- W4313395861 cites W2016998310 @default.
- W4313395861 cites W2017739927 @default.
- W4313395861 cites W2032396306 @default.
- W4313395861 cites W2045751335 @default.
- W4313395861 cites W2057993014 @default.
- W4313395861 cites W2086553875 @default.
- W4313395861 cites W2093475081 @default.
- W4313395861 cites W2102424000 @default.
- W4313395861 cites W2105183657 @default.
- W4313395861 cites W2106104578 @default.
- W4313395861 cites W2122432702 @default.
- W4313395861 cites W2124010228 @default.
- W4313395861 cites W2291772488 @default.
- W4313395861 cites W2327421171 @default.
- W4313395861 cites W2334335327 @default.
- W4313395861 cites W2341934538 @default.
- W4313395861 cites W2461993137 @default.
- W4313395861 cites W2530064321 @default.
- W4313395861 cites W2603886489 @default.
- W4313395861 cites W2786739900 @default.
- W4313395861 cites W2932304820 @default.
- W4313395861 cites W2951866067 @default.
- W4313395861 cites W3196903026 @default.
- W4313395861 cites W3202949235 @default.
- W4313395861 cites W4213437856 @default.
- W4313395861 cites W4220720897 @default.
- W4313395861 cites W4253644521 @default.
- W4313395861 doi "https://doi.org/10.1248/cpb.c22-00715" @default.
- W4313395861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36596505" @default.
- W4313395861 hasPublicationYear "2023" @default.
- W4313395861 type Work @default.
- W4313395861 citedByCount "2" @default.
- W4313395861 countsByYear W43133958612023 @default.
- W4313395861 crossrefType "journal-article" @default.
- W4313395861 hasAuthorship W4313395861A5064472249 @default.
- W4313395861 hasBestOaLocation W43133958611 @default.
- W4313395861 hasConcept C116073593 @default.
- W4313395861 hasConcept C181199279 @default.
- W4313395861 hasConcept C185592680 @default.
- W4313395861 hasConcept C202751555 @default.
- W4313395861 hasConcept C2777289909 @default.
- W4313395861 hasConcept C2778849931 @default.
- W4313395861 hasConcept C43144210 @default.
- W4313395861 hasConcept C523546767 @default.
- W4313395861 hasConcept C54355233 @default.
- W4313395861 hasConcept C553450214 @default.
- W4313395861 hasConcept C55493867 @default.
- W4313395861 hasConcept C59822182 @default.
- W4313395861 hasConcept C86803240 @default.
- W4313395861 hasConceptScore W4313395861C116073593 @default.
- W4313395861 hasConceptScore W4313395861C181199279 @default.
- W4313395861 hasConceptScore W4313395861C185592680 @default.
- W4313395861 hasConceptScore W4313395861C202751555 @default.
- W4313395861 hasConceptScore W4313395861C2777289909 @default.
- W4313395861 hasConceptScore W4313395861C2778849931 @default.
- W4313395861 hasConceptScore W4313395861C43144210 @default.
- W4313395861 hasConceptScore W4313395861C523546767 @default.
- W4313395861 hasConceptScore W4313395861C54355233 @default.
- W4313395861 hasConceptScore W4313395861C553450214 @default.
- W4313395861 hasConceptScore W4313395861C55493867 @default.
- W4313395861 hasConceptScore W4313395861C59822182 @default.
- W4313395861 hasConceptScore W4313395861C86803240 @default.
- W4313395861 hasIssue "1" @default.
- W4313395861 hasLocation W43133958611 @default.
- W4313395861 hasLocation W43133958612 @default.
- W4313395861 hasOpenAccess W4313395861 @default.
- W4313395861 hasPrimaryLocation W43133958611 @default.
- W4313395861 hasRelatedWork W1984663423 @default.
- W4313395861 hasRelatedWork W2004165914 @default.
- W4313395861 hasRelatedWork W2020222675 @default.
- W4313395861 hasRelatedWork W2036862393 @default.
- W4313395861 hasRelatedWork W2044991043 @default.
- W4313395861 hasRelatedWork W2053044254 @default.
- W4313395861 hasRelatedWork W2581719739 @default.
- W4313395861 hasRelatedWork W2904104720 @default.
- W4313395861 hasRelatedWork W2962723991 @default.
- W4313395861 hasRelatedWork W3166638147 @default.
- W4313395861 hasVolume "71" @default.
- W4313395861 isParatext "false" @default.
- W4313395861 isRetracted "false" @default.
- W4313395861 workType "article" @default.