FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313396054> ?p ?o ?g. }

• W4313396054 abstract "Abstract Purpose Previous studies showed that peroxisome proliferator-activated receptor gamma ( PPARγ ) and PPARγ coactivator1 family ( PPARGC1A and PPARGC1B ) gene single nucleotide variants (SNVs)were strongly associated with cancer susceptibility. The purpose of this study was to investigate the association of PPARγ , PPARGC1A , and PPARGC1B variants with the risk of gastric cancer (GC). Patients and methods We performed a case-control study of 490 GC cases and 1,476 healthy controls from eastern China. PPARγ rs1801282 C > G, rs3856806 C > T, PPARGC1A rs2970847 C > T, rs8192678 C > T and PPARGC1B rs7732671 G > C, rs17572019 G > A SNVs were selected to investigate the association between these SNVs and GC susceptibility. Genotypes of the SNVs were assessed by multiplex fluorescent PCR using a custom-by-design 48-Plex SNPscan tm Kit. Results The PPARγ rs1801282 SNV was associated with a decreased risk for GC (GC vs. CC: odds ratio (OR) = 0.62, 95% confidence interval (95%CI) = 0.42–0.93, adjusted P = 0.019; GC + GG vs. GG: OR = 0.63 95%CI = 0.42–0.93, adjusted P = 0.019; respectively). In addition, stratified analysis revealed that the PPARγ rs1801282 SNV was correlated with the risk of GC in subgroups of age ≥ 61, no smoking, and no alcohol consuming. We also confirmed that the PPARγ rs3856806 C > T SNV promoted the risk of GC in women. The PPARGC1A rs8192678 TT genotype decreased the susceptibility of GC in men. The PPARGC1A rs2970847 C > T SNV decreased the susceptibility of GC in the subgroup of BMI ≥ 24 kg/m 2 . The PPARGC1B rs7732671 G > C and rs17572019 G > A SNVs promoted the risk of GC in the subgroup of BMI ≥ 24 kg/m 2 . Conclusion This study indicates that the PPARγ , PPARGC1A , and PPARGC1B SNVs may be associated with the susceptibility of GC in eastern Chinese population. Future studies with larger populations, detailed H. pylori infection status for subgroup analysis, and functional study are needed to further clarify the relationship between these SNVs and GC risk." @default.
• W4313396054 created "2023-01-06" @default.
• W4313396054 creator A5009019549 @default.
• W4313396054 creator A5019672077 @default.
• W4313396054 creator A5028296024 @default.
• W4313396054 creator A5042326776 @default.
• W4313396054 creator A5043505664 @default.
• W4313396054 creator A5052676364 @default.
• W4313396054 creator A5081924800 @default.
• W4313396054 date "2022-12-31" @default.
• W4313396054 modified "2023-09-26" @default.
• W4313396054 title "Association between PPARγ, PPARGC1A, and PPARGC1B genetic variants and susceptibility of gastric cancer in an Eastern Chinese population" @default.
• W4313396054 cites W1491552196 @default.
• W4313396054 cites W1527649416 @default.
• W4313396054 cites W1856818388 @default.
• W4313396054 cites W1871761830 @default.
• W4313396054 cites W1874947654 @default.
• W4313396054 cites W1964203123 @default.
• W4313396054 cites W1970526536 @default.
• W4313396054 cites W1979069710 @default.
• W4313396054 cites W1987403686 @default.
• W4313396054 cites W2001419494 @default.
• W4313396054 cites W2036168963 @default.
• W4313396054 cites W2043538397 @default.
• W4313396054 cites W2049421726 @default.
• W4313396054 cites W2050397437 @default.
• W4313396054 cites W2054088364 @default.
• W4313396054 cites W2055938710 @default.
• W4313396054 cites W2065105192 @default.
• W4313396054 cites W2070673845 @default.
• W4313396054 cites W2078894227 @default.
• W4313396054 cites W2085374171 @default.
• W4313396054 cites W2089195915 @default.
• W4313396054 cites W2094468036 @default.
• W4313396054 cites W2108987136 @default.
• W4313396054 cites W2109808592 @default.
• W4313396054 cites W2111275015 @default.
• W4313396054 cites W2118653540 @default.
• W4313396054 cites W2124110970 @default.
• W4313396054 cites W2125931727 @default.
• W4313396054 cites W2130628544 @default.
• W4313396054 cites W2135354463 @default.
• W4313396054 cites W2141474026 @default.
• W4313396054 cites W2144381624 @default.
• W4313396054 cites W2157199218 @default.
• W4313396054 cites W2160769801 @default.
• W4313396054 cites W2287556702 @default.
• W4313396054 cites W2303508646 @default.
• W4313396054 cites W2334390235 @default.
• W4313396054 cites W2408377145 @default.
• W4313396054 cites W2484298180 @default.
• W4313396054 cites W2566947486 @default.
• W4313396054 cites W2595908974 @default.
• W4313396054 cites W2744425601 @default.
• W4313396054 cites W2752131577 @default.
• W4313396054 cites W2754106059 @default.
• W4313396054 cites W2767228538 @default.
• W4313396054 cites W2786195411 @default.
• W4313396054 cites W2788857340 @default.
• W4313396054 cites W2790985071 @default.
• W4313396054 cites W2791638612 @default.
• W4313396054 cites W2791809411 @default.
• W4313396054 cites W2791851888 @default.
• W4313396054 cites W2803042798 @default.
• W4313396054 cites W2806567377 @default.
• W4313396054 cites W2887808746 @default.
• W4313396054 cites W2912750560 @default.
• W4313396054 cites W2916750889 @default.
• W4313396054 cites W2922487514 @default.
• W4313396054 cites W2946104530 @default.
• W4313396054 cites W2972294778 @default.
• W4313396054 cites W2980024320 @default.
• W4313396054 cites W2982478380 @default.
• W4313396054 cites W2983529467 @default.
• W4313396054 cites W3045664495 @default.
• W4313396054 cites W3128646645 @default.
• W4313396054 cites W3129313232 @default.
• W4313396054 cites W3154960443 @default.
• W4313396054 cites W3185274265 @default.
• W4313396054 cites W3213317676 @default.
• W4313396054 cites W4286697401 @default.
• W4313396054 cites W4287500167 @default.
• W4313396054 cites W4288610655 @default.
• W4313396054 cites W2924901381 @default.
• W4313396054 doi "https://doi.org/10.1186/s12920-022-01428-0" @default.
• W4313396054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36587194" @default.
• W4313396054 hasPublicationYear "2022" @default.
• W4313396054 type Work @default.
• W4313396054 citedByCount "2" @default.
• W4313396054 countsByYear W43133960542023 @default.
• W4313396054 crossrefType "journal-article" @default.
• W4313396054 hasAuthorship W4313396054A5009019549 @default.
• W4313396054 hasAuthorship W4313396054A5019672077 @default.
• W4313396054 hasAuthorship W4313396054A5028296024 @default.
• W4313396054 hasAuthorship W4313396054A5042326776 @default.
• W4313396054 hasAuthorship W4313396054A5043505664 @default.
• W4313396054 hasAuthorship W4313396054A5052676364 @default.
• W4313396054 hasAuthorship W4313396054A5081924800 @default.
• W4313396054 hasBestOaLocation W43133960541 @default.
• W4313396054 hasConcept C104317684 @default.

• next