Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313396812> ?p ?o ?g. }
- W4313396812 abstract "Animal models and static cultures of intestinal epithelial cells are commonly used platforms for exploring mercury ion (Hg(II)) transport. However, they cannot reliably simulate the human intestinal microenvironment and monitor cellular physiology in situ; thus, the mechanism of Hg(II) transport in the human intestine is still unclear. Here, a gut-on-a-chip integrated with transepithelial electrical resistance (TEER) sensors and electrochemical sensors is proposed for dynamically simulating the formation of the physical intestinal barrier and monitoring the transport and absorption of Hg(II) in situ. The cellular microenvironment was recreated by applying fluid shear stress (0.02 dyne/cm2) and cyclic mechanical strain (1%, 0.15 Hz). Hg(II) absorption and physical damage to cells were simultaneously monitored by electrochemical and TEER sensors when intestinal epithelial cells were exposed to different concentrations of Hg(II) mixed in culture medium. Hg(II) absorption increased by 23.59% when tensile strain increased from 1% to 5%, and the corresponding expression of Piezo1 and DMT1 on the cell surface was upregulated." @default.
- W4313396812 created "2023-01-06" @default.
- W4313396812 creator A5018886747 @default.
- W4313396812 creator A5030864433 @default.
- W4313396812 creator A5033405542 @default.
- W4313396812 creator A5038935394 @default.
- W4313396812 creator A5044525499 @default.
- W4313396812 creator A5059957610 @default.
- W4313396812 creator A5060180606 @default.
- W4313396812 creator A5068603055 @default.
- W4313396812 creator A5076480384 @default.
- W4313396812 creator A5082857859 @default.
- W4313396812 date "2023-01-01" @default.
- W4313396812 modified "2023-10-18" @default.
- W4313396812 title "Gut-on-a-chip for exploring the transport mechanism of Hg(II)" @default.
- W4313396812 cites W1975159161 @default.
- W4313396812 cites W1980648962 @default.
- W4313396812 cites W1984786686 @default.
- W4313396812 cites W2013520568 @default.
- W4313396812 cites W2021801968 @default.
- W4313396812 cites W2027842702 @default.
- W4313396812 cites W2030639826 @default.
- W4313396812 cites W2055195052 @default.
- W4313396812 cites W2069105811 @default.
- W4313396812 cites W2071505227 @default.
- W4313396812 cites W2154555351 @default.
- W4313396812 cites W2158054403 @default.
- W4313396812 cites W2168752825 @default.
- W4313396812 cites W2214747519 @default.
- W4313396812 cites W2400572598 @default.
- W4313396812 cites W2416689747 @default.
- W4313396812 cites W2560395594 @default.
- W4313396812 cites W2695416662 @default.
- W4313396812 cites W2753784244 @default.
- W4313396812 cites W2886103315 @default.
- W4313396812 cites W2901744482 @default.
- W4313396812 cites W2911032805 @default.
- W4313396812 cites W2920586988 @default.
- W4313396812 cites W2943483885 @default.
- W4313396812 cites W2944263569 @default.
- W4313396812 cites W2952977804 @default.
- W4313396812 cites W2957584563 @default.
- W4313396812 cites W2971766156 @default.
- W4313396812 cites W2996090545 @default.
- W4313396812 cites W2999641649 @default.
- W4313396812 cites W3002451359 @default.
- W4313396812 cites W3035754026 @default.
- W4313396812 cites W3087653149 @default.
- W4313396812 cites W3091671140 @default.
- W4313396812 cites W3133779799 @default.
- W4313396812 cites W3159899614 @default.
- W4313396812 cites W3167503613 @default.
- W4313396812 cites W3200195734 @default.
- W4313396812 cites W3214161513 @default.
- W4313396812 cites W74582721 @default.
- W4313396812 doi "https://doi.org/10.1038/s41378-022-00447-2" @default.
- W4313396812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36597512" @default.
- W4313396812 hasPublicationYear "2023" @default.
- W4313396812 type Work @default.
- W4313396812 citedByCount "8" @default.
- W4313396812 countsByYear W43133968122023 @default.
- W4313396812 crossrefType "journal-article" @default.
- W4313396812 hasAuthorship W4313396812A5018886747 @default.
- W4313396812 hasAuthorship W4313396812A5030864433 @default.
- W4313396812 hasAuthorship W4313396812A5033405542 @default.
- W4313396812 hasAuthorship W4313396812A5038935394 @default.
- W4313396812 hasAuthorship W4313396812A5044525499 @default.
- W4313396812 hasAuthorship W4313396812A5059957610 @default.
- W4313396812 hasAuthorship W4313396812A5060180606 @default.
- W4313396812 hasAuthorship W4313396812A5068603055 @default.
- W4313396812 hasAuthorship W4313396812A5076480384 @default.
- W4313396812 hasAuthorship W4313396812A5082857859 @default.
- W4313396812 hasBestOaLocation W43133968121 @default.
- W4313396812 hasConcept C125287762 @default.
- W4313396812 hasConcept C12554922 @default.
- W4313396812 hasConcept C159985019 @default.
- W4313396812 hasConcept C185592680 @default.
- W4313396812 hasConcept C192562407 @default.
- W4313396812 hasConcept C86803240 @default.
- W4313396812 hasConceptScore W4313396812C125287762 @default.
- W4313396812 hasConceptScore W4313396812C12554922 @default.
- W4313396812 hasConceptScore W4313396812C159985019 @default.
- W4313396812 hasConceptScore W4313396812C185592680 @default.
- W4313396812 hasConceptScore W4313396812C192562407 @default.
- W4313396812 hasConceptScore W4313396812C86803240 @default.
- W4313396812 hasIssue "1" @default.
- W4313396812 hasLocation W43133968121 @default.
- W4313396812 hasLocation W43133968122 @default.
- W4313396812 hasLocation W43133968123 @default.
- W4313396812 hasOpenAccess W4313396812 @default.
- W4313396812 hasPrimaryLocation W43133968121 @default.
- W4313396812 hasRelatedWork W1531601525 @default.
- W4313396812 hasRelatedWork W2319480705 @default.
- W4313396812 hasRelatedWork W2384464875 @default.
- W4313396812 hasRelatedWork W2398689458 @default.
- W4313396812 hasRelatedWork W2606230654 @default.
- W4313396812 hasRelatedWork W2607424097 @default.
- W4313396812 hasRelatedWork W2748952813 @default.
- W4313396812 hasRelatedWork W2899084033 @default.
- W4313396812 hasRelatedWork W2948807893 @default.