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• W4313397051 startingPage "1098" @default.
• W4313397051 abstract "Animal models of substance use disorders have been criticized for their limited translation. One important factor behind seeking and taking that has so far been largely overlooked is the availability of alternative non-drug rewards. We recently reported that only about 15% of outbred Wistar rats will choose alcohol over a sweet solution of saccharin. It was also shown using a novel operant model of choice of drugs over social rewards that social interaction consistently attenuates self-administration and incubation of craving for stimulants and opioids. Whether this is also true for alcohol and choice of alcohol over a sweet reward translates to social rewards is currently unknown. We therefore evaluated choice between alcohol and a social reward in different experimental settings in both male and female Wistar rats. We found, in contrast to prior work that employed discrete choice of drugs vs. social reward, that rats almost exclusively prefer alcohol over social interaction, irrespective of the nature of the social partner (cagemate vs. novel rat), the length of interaction, housing conditions and sex. Alcohol choice was reduced when the response requirement for alcohol was increased. However, rats persisted in choosing alcohol, even when the effort required to obtain it was 10-16 times higher (for females and males respectively) than the one for the social reward. Altogether, these results indicate that the social choice model may not generalize to alcohol, pointing to the possibility that specific interactions between alcohol and social reward, not seen when a sweet solution is used as an alternative to the drug, may play a crucial role in alcohol vs. social choice experiments." @default.
• W4313397051 created "2023-01-06" @default.
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• W4313397051 date "2022-12-31" @default.
• W4313397051 modified "2023-10-01" @default.
• W4313397051 title "Wistar rats choose alcohol over social interaction in a discrete-choice model" @default.
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• W4313397051 doi "https://doi.org/10.1038/s41386-022-01526-8" @default.
• W4313397051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36587185" @default.
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