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• W4313397444 abstract "Non-surgical treatment of Peyronie's disease remains a treatment dilemma. In spite of all the different types of treatments which have been offered since the time of de la Peyronie we still do not have a reliable and effective treatment. 1 Li E Esterquest R Pham M. Peyronie's disease: pharmacological treatment's and limitations. Expert Rev Clin Pharm. 2021; 14: 703-713 Crossref PubMed Scopus (2) Google Scholar We do have one FDA approved therapy with Collagenase Clostridium histolyticum (CCH) but there is not uniform agreement in the literature or among experts as to its efficacy. In addition, CCH is not likely to completely correct the deformity. Reported curvature reduction typically remains in the 15%-30% range and it does not correct length loss, indentation deformities or improve erectile dysfunction. Before CCH was approved in 2013, intralesional verapamil (ILV) was the most commonly used injection therapy. 2 Shindel AW Bullock TL Brandes S. Urologist practice patterns in the management of Peyronie's disease: a nationwide survey. J Sex Med. 2008; 5: 954-964 Crossref PubMed Scopus (42) Google Scholar Several reviews and meta-analyses have shown conflicting results regarding the efficacy of ILV particularly when the few controlled trials are the only ones included in the review. 3 Ory J MacDonald L Langille G. Noninvassive treatment options for Peyronie's disease. Sex Med Rev. 2020; 8: 603-614 Crossref PubMed Scopus (3) Google Scholar ,4 Russo GI, Cacciamani G, Cocci A. Comparative effectiveness of intralesional therapy for Peyronie's disease in controlled clinical studies. J Sex Med. 2019;16:289–299 Google Scholar The purpose of this editorial is to review the history of intralesional verapamil and how it all started." @default.
• W4313397444 created "2023-01-06" @default.
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• W4313397444 date "2023-03-01" @default.
• W4313397444 modified "2023-09-25" @default.
• W4313397444 title "A Primer on the History of Intralesional Verapamil Injection for Peyronie's Disease" @default.
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• W4313397444 doi "https://doi.org/10.1016/j.urology.2022.12.022" @default.
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