Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313398460> ?p ?o ?g. }
- W4313398460 endingPage "154609" @default.
- W4313398460 startingPage "154609" @default.
- W4313398460 abstract "Ischemic stroke (IS) is a leading cause of death and severe long-term disability worldwide. Over the past few decades, considerable progress has been made in anti-ischemic therapies. However, IS remains a tremendous challenge, with favourable clinical outcomes being generally difficult to achieve from candidate drugs in preclinical phase testing. Traditional herbal medicine (THM) has been used to treat stroke for over 2,000 years in China. In modern times, THM as an alternative and complementary therapy have been prescribed in other Asian countries and have gained increasing attention for their therapeutic effects. These millennia of clinical experience allow THM to be a promising avenue for improving clinical efficacy and accelerating drug discovery.To summarise the clinical evidence and potential mechanisms of THMs in IS.A comprehensive literature search was conducted in seven electronic databases, including PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, the Chinese National Knowledge Infrastructure, the VIP Information Database, the Chinese Biomedical Literature Database, and the Wanfang Database, from inception to 17 June 2022 to examine the efficacy and safety of THM for IS, and to investigate experimental studies regarding potential mechanisms.THM is widely prescribed for IS alone or as adjuvant therapy. In clinical trials, THM is generally administered within 72 h of stroke onset and are continuously prescribed for over 3 months. Compared with Western medicine (WM), THM combined with routine WM can significantly improve neurological function defect scores, promote clinical total effective rate, and accelerate the recovery time of stroke with fewer adverse effects (AEs). These effects can be attributed to multiple mechanisms, mainly anti-inflammation, antioxidative stress, anti-apoptosis, brain blood barrier (BBB) modulation, inhibition of platelet activation and thrombus formation, and promotion of neurogenesis and angiogenesis.THM may be a promising candidate for IS management to guide clinical applications and as a reference for drug development." @default.
- W4313398460 created "2023-01-06" @default.
- W4313398460 creator A5014483195 @default.
- W4313398460 creator A5017974753 @default.
- W4313398460 creator A5034466971 @default.
- W4313398460 creator A5053783274 @default.
- W4313398460 creator A5066141547 @default.
- W4313398460 creator A5069995368 @default.
- W4313398460 creator A5089549114 @default.
- W4313398460 date "2023-01-01" @default.
- W4313398460 modified "2023-10-13" @default.
- W4313398460 title "The role of traditional herbal medicine for ischemic stroke: from bench to clinic—A critical review" @default.
- W4313398460 cites W1496784087 @default.
- W4313398460 cites W1539813960 @default.
- W4313398460 cites W1567992432 @default.
- W4313398460 cites W1824377721 @default.
- W4313398460 cites W1898488005 @default.
- W4313398460 cites W1964210744 @default.
- W4313398460 cites W1965066504 @default.
- W4313398460 cites W1966464689 @default.
- W4313398460 cites W1974458552 @default.
- W4313398460 cites W1975153455 @default.
- W4313398460 cites W1976643329 @default.
- W4313398460 cites W1978100049 @default.
- W4313398460 cites W1979982978 @default.
- W4313398460 cites W1980095151 @default.
- W4313398460 cites W1981233586 @default.
- W4313398460 cites W1982049788 @default.
- W4313398460 cites W1985455477 @default.
- W4313398460 cites W1985607313 @default.
- W4313398460 cites W1988498803 @default.
- W4313398460 cites W1988983508 @default.
- W4313398460 cites W1990402860 @default.
- W4313398460 cites W1996817731 @default.
- W4313398460 cites W1997424221 @default.
- W4313398460 cites W2001128989 @default.
- W4313398460 cites W2011205918 @default.
- W4313398460 cites W2013354889 @default.
- W4313398460 cites W2016951160 @default.
- W4313398460 cites W2021199020 @default.
- W4313398460 cites W2021847325 @default.
- W4313398460 cites W2023125814 @default.
- W4313398460 cites W2030300220 @default.
- W4313398460 cites W2032369221 @default.
- W4313398460 cites W2032955926 @default.
- W4313398460 cites W2037999176 @default.
- W4313398460 cites W2042206838 @default.
- W4313398460 cites W2048398316 @default.
- W4313398460 cites W2049028154 @default.
- W4313398460 cites W2049938699 @default.
- W4313398460 cites W2050099527 @default.
- W4313398460 cites W2054109796 @default.
- W4313398460 cites W2056980970 @default.
- W4313398460 cites W2058265794 @default.
- W4313398460 cites W2058337748 @default.
- W4313398460 cites W2061751462 @default.
- W4313398460 cites W2066189463 @default.
- W4313398460 cites W2072016181 @default.
- W4313398460 cites W2074858975 @default.
- W4313398460 cites W2076419826 @default.
- W4313398460 cites W2077387648 @default.
- W4313398460 cites W2078151810 @default.
- W4313398460 cites W2080625218 @default.
- W4313398460 cites W2083004303 @default.
- W4313398460 cites W2085286173 @default.
- W4313398460 cites W2085637809 @default.
- W4313398460 cites W2089401978 @default.
- W4313398460 cites W2099521929 @default.
- W4313398460 cites W2099859337 @default.
- W4313398460 cites W2104416130 @default.
- W4313398460 cites W2113481537 @default.
- W4313398460 cites W2114429672 @default.
- W4313398460 cites W2118200665 @default.
- W4313398460 cites W2118901526 @default.
- W4313398460 cites W2121158877 @default.
- W4313398460 cites W2122342236 @default.
- W4313398460 cites W2126329290 @default.
- W4313398460 cites W2126452122 @default.
- W4313398460 cites W2127642000 @default.
- W4313398460 cites W2134813179 @default.
- W4313398460 cites W2136055326 @default.
- W4313398460 cites W2139883218 @default.
- W4313398460 cites W2155198114 @default.
- W4313398460 cites W2159186412 @default.
- W4313398460 cites W2165808411 @default.
- W4313398460 cites W2168125635 @default.
- W4313398460 cites W2171495842 @default.
- W4313398460 cites W2172000133 @default.
- W4313398460 cites W2174450372 @default.
- W4313398460 cites W2175250885 @default.
- W4313398460 cites W2185141034 @default.
- W4313398460 cites W2194565004 @default.
- W4313398460 cites W2236846011 @default.
- W4313398460 cites W2274020401 @default.
- W4313398460 cites W2277032204 @default.
- W4313398460 cites W2287772836 @default.
- W4313398460 cites W2293721491 @default.
- W4313398460 cites W2314158590 @default.