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• W4313398522 startingPage "216" @default.
• W4313398522 abstract "Celastrol, extracted from Tripterygium wilfordii Hook F, is one of the most promising natural extract for cancer treatment. Nevertheless, insufficient tumor retention and severe systemic toxicity still hinder its application. Herein, we report for the first time that Celastrol can directly self-assemble into size-controllable nanoparticles through the anti-solvent method by using different good solvent or by the variation of Celastrol concentrations. In vitro anti-cancer experiment revealed that the as-prepared nanoparticles can kill MCF-7 cells more effectively. Moreover, the nanoparticles can efficiently accumulate in tumors of the tumor bearing mice after tail vein injection. Under the administration of lethal dosage of Celastrol, the tumors are greatly suppressed and the mice maintain the activity. These results demonstrate that anti-solvent method may be a promising strategy to fabricate Celastrol nano-drugs with controllable size and less systemic toxicity for further clinical cancer treatment." @default.
• W4313398522 created "2023-01-06" @default.
• W4313398522 creator A5030866854 @default.
• W4313398522 creator A5063711265 @default.
• W4313398522 date "2023-04-01" @default.
• W4313398522 modified "2023-10-17" @default.
• W4313398522 title "Self-assembling nanoarchitectonics of size-controllable celastrol nanoparticles for efficient cancer chemotherapy with reduced systemic toxicity" @default.
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• W4313398522 doi "https://doi.org/10.1016/j.jcis.2022.12.162" @default.
• W4313398522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36634391" @default.
• W4313398522 hasPublicationYear "2023" @default.
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