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- W4313398723 abstract "DNA-based biomimetic enzymes have attracted extensive attention due to their unique structure and stability compared to natural enzymes. Meanwhile, the specific sequences of DNA itself also have a catalytic effect. Herein, we first designed three guanine-rich DNA sequences numbered c−Myc3c, PG4TC, and TTT to construct g−quadruplex/hemin DNAzymes. Then, the g−quadruplex/hemin DNAzymes with the best activity were selected by a comprehensive examination of activity, degradation rate, and affinity. Subsequently, the stability and reusability of UiO66−DNAzymes were investigated using UiO66 as the carrier to immobilize DNAzymes. The results showed that UiO66−DNAzymes had excellent reusability and stability. Finally, UiO66−DNAzymes were successfully used for glucose detection by cascading with glucose oxidase (GOx) with a detection limit of 0.62 μM. The constructed glucose sensor had a good specificity, which is of great significance for developing a novel, accurate, fast, and economical glucose detection sensor." @default.
- W4313398723 created "2023-01-06" @default.
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- W4313398723 date "2022-12-30" @default.
- W4313398723 modified "2023-10-05" @default.
- W4313398723 title "MOF-Based G−Quadruplex/Hemin DNAzymes for Cascade Reaction" @default.
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- W4313398723 doi "https://doi.org/10.3390/catal13010081" @default.
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