FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313398930> ?p ?o ?g. }

• W4313398930 endingPage "102864" @default.
• W4313398930 startingPage "102864" @default.
• W4313398930 abstract "In response to environmental stresses, cells invoke translational control to conserve resources and rapidly reprogram gene expression for optimal adaptation. A central mechanism for translational control involves phosphorylation of the α subunit of eIF2 (p-eIF2α), which reduces delivery of initiator tRNA to ribosomes. Because p-eIF2α is invoked by multiple protein kinases, each responding to distinct stresses, this pathway is named the integrated stress response (ISR). While p-eIF2α lowers bulk translation initiation, many stress-related mRNAs are preferentially translated. The process by which ribosomes delineate gene transcripts for preferential translation is known to involve upstream open reading frames (uORFs) embedded in the targeted mRNAs. In this study, we used polysome analyses and reporter assays to address the mechanisms directing preferential translation of human IBTKα in the ISR. The IBTKα mRNA encodes four uORFs, with only 5'-proximal uORF1 and uORF2 being translated. Of importance, the 5'-leader of IBTKα mRNA also contains a phylogenetically conserved stem-loop of moderate stability that is situated 11 nucleotides downstream of uORF2. The uORF2 is well translated and functions in combination with the stem-loop to effectively lower translation reinitiation at the IBTKα coding sequence. Upon stress-induced p-eIF2α, the uORF2/stem loop element can be bypassed to enhance IBTKα translation by a mechanism that may involve the modestly translated uORF1. Our study demonstrates that uORFs in conjunction with RNA secondary structures can be critical elements that serve as the bar code by which scanning ribosomes can delineate which mRNAs are preferentially translated in the ISR." @default.
• W4313398930 created "2023-01-06" @default.
• W4313398930 creator A5052831493 @default.
• W4313398930 creator A5061521155 @default.
• W4313398930 creator A5082229689 @default.
• W4313398930 date "2023-02-01" @default.
• W4313398930 modified "2023-10-14" @default.
• W4313398930 title "An RNA stem-loop functions in conjunction with an upstream open reading frame to direct preferential translation in the integrated stress response" @default.
• W4313398930 cites W1530012584 @default.
• W4313398930 cites W1913136372 @default.
• W4313398930 cites W1979168172 @default.
• W4313398930 cites W1980438612 @default.
• W4313398930 cites W1984426737 @default.
• W4313398930 cites W1991250346 @default.
• W4313398930 cites W2003924215 @default.
• W4313398930 cites W2008410413 @default.
• W4313398930 cites W2026487666 @default.
• W4313398930 cites W2042173490 @default.
• W4313398930 cites W2050561023 @default.
• W4313398930 cites W2062387508 @default.
• W4313398930 cites W2074471441 @default.
• W4313398930 cites W2077784911 @default.
• W4313398930 cites W2084828728 @default.
• W4313398930 cites W2100472948 @default.
• W4313398930 cites W2101445704 @default.
• W4313398930 cites W2102050179 @default.
• W4313398930 cites W2102528998 @default.
• W4313398930 cites W2118337461 @default.
• W4313398930 cites W2127848114 @default.
• W4313398930 cites W2131632095 @default.
• W4313398930 cites W2135608010 @default.
• W4313398930 cites W2141030634 @default.
• W4313398930 cites W2154241726 @default.
• W4313398930 cites W2255242978 @default.
• W4313398930 cites W2283081262 @default.
• W4313398930 cites W2287056933 @default.
• W4313398930 cites W2427010553 @default.
• W4313398930 cites W2463069668 @default.
• W4313398930 cites W2582200059 @default.
• W4313398930 cites W2734349639 @default.
• W4313398930 cites W2785892239 @default.
• W4313398930 cites W2787351196 @default.
• W4313398930 cites W3082191894 @default.
• W4313398930 cites W4210762403 @default.
• W4313398930 cites W4214664908 @default.
• W4313398930 doi "https://doi.org/10.1016/j.jbc.2022.102864" @default.
• W4313398930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36596357" @default.
• W4313398930 hasPublicationYear "2023" @default.
• W4313398930 type Work @default.
• W4313398930 citedByCount "3" @default.
• W4313398930 countsByYear W43133989302023 @default.
• W4313398930 crossrefType "journal-article" @default.
• W4313398930 hasAuthorship W4313398930A5052831493 @default.
• W4313398930 hasAuthorship W4313398930A5061521155 @default.
• W4313398930 hasAuthorship W4313398930A5082229689 @default.
• W4313398930 hasBestOaLocation W43133989301 @default.
• W4313398930 hasConcept C104317684 @default.
• W4313398930 hasConcept C105580179 @default.
• W4313398930 hasConcept C149364088 @default.
• W4313398930 hasConcept C153957851 @default.
• W4313398930 hasConcept C166258313 @default.
• W4313398930 hasConcept C167625842 @default.
• W4313398930 hasConcept C2779638656 @default.
• W4313398930 hasConcept C3675279 @default.
• W4313398930 hasConcept C39685955 @default.
• W4313398930 hasConcept C4718897 @default.
• W4313398930 hasConcept C47289529 @default.
• W4313398930 hasConcept C54355233 @default.
• W4313398930 hasConcept C65666806 @default.
• W4313398930 hasConcept C67705224 @default.
• W4313398930 hasConcept C86803240 @default.
• W4313398930 hasConcept C88478588 @default.
• W4313398930 hasConcept C93734116 @default.
• W4313398930 hasConcept C95444343 @default.
• W4313398930 hasConceptScore W4313398930C104317684 @default.
• W4313398930 hasConceptScore W4313398930C105580179 @default.
• W4313398930 hasConceptScore W4313398930C149364088 @default.
• W4313398930 hasConceptScore W4313398930C153957851 @default.
• W4313398930 hasConceptScore W4313398930C166258313 @default.
• W4313398930 hasConceptScore W4313398930C167625842 @default.
• W4313398930 hasConceptScore W4313398930C2779638656 @default.
• W4313398930 hasConceptScore W4313398930C3675279 @default.
• W4313398930 hasConceptScore W4313398930C39685955 @default.
• W4313398930 hasConceptScore W4313398930C4718897 @default.
• W4313398930 hasConceptScore W4313398930C47289529 @default.
• W4313398930 hasConceptScore W4313398930C54355233 @default.
• W4313398930 hasConceptScore W4313398930C65666806 @default.
• W4313398930 hasConceptScore W4313398930C67705224 @default.
• W4313398930 hasConceptScore W4313398930C86803240 @default.
• W4313398930 hasConceptScore W4313398930C88478588 @default.
• W4313398930 hasConceptScore W4313398930C93734116 @default.
• W4313398930 hasConceptScore W4313398930C95444343 @default.
• W4313398930 hasIssue "2" @default.
• W4313398930 hasLocation W43133989301 @default.
• W4313398930 hasLocation W43133989302 @default.
• W4313398930 hasLocation W43133989303 @default.
• W4313398930 hasOpenAccess W4313398930 @default.
• W4313398930 hasPrimaryLocation W43133989301 @default.

• next