Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313402566> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4313402566 endingPage "75.11" @default.
- W4313402566 startingPage "75.11" @default.
- W4313402566 abstract "Abstract We previously showed that crossreactivity is common between IAV and EBV in HLA-A2+ patients during infectious mononucleosis. IAV-M1 specific CD8 T cells, along with expanded populations of IAV-M1/EBV-BRLF-1 and IAV-M1/EBV-BMLF-1 double-tetramer+ cells were detected directly ex-vivo in 5 HLA-A2+ patients. Altered IAV-M1, EBV-BRLF1 and -BMLF1 TCR repertoires were observed over the course of infection and in comparison to healthy donors. After culture, cells were sorted and analyzed by gene array in order to assess global changes in immune responses following different stimulations, either cognate or crossreactive, in different patient populations. M1- and BRLF1-specific cells had similar immune-response gene signatures, but the BMLF1-specific CD8 cells were more similar to the two-crossreactive populations. Crossreactive M1/BRLF1 cells from the BRLF1 line were different in their activation status than the BRLF1-specific cells, consistent with BRLF1 ligand stimulation of different gene activation profiles in these two populations. These results suggest that during symptomatic IAV infection there is an expansion of EBV/IAV crossreactive memory CD8 T cell responses. Ongoing studies are investigating whether EBV-IAV cross-reactive CD8+ T cells may contribute to immunopathology during acute IAV infection." @default.
- W4313402566 created "2023-01-06" @default.
- W4313402566 creator A5003506051 @default.
- W4313402566 creator A5007129617 @default.
- W4313402566 creator A5034211371 @default.
- W4313402566 creator A5045061206 @default.
- W4313402566 creator A5072583461 @default.
- W4313402566 date "2014-05-01" @default.
- W4313402566 modified "2023-10-02" @default.
- W4313402566 title "Crossreactive Epstein-Barr virus (EBV)-influenza A virus (IAV) specific CD8 memory T cells during acute symptomatic IAV infection. (VIR2P.1022)" @default.
- W4313402566 doi "https://doi.org/10.4049/jimmunol.192.supp.75.11" @default.
- W4313402566 hasPublicationYear "2014" @default.
- W4313402566 type Work @default.
- W4313402566 citedByCount "0" @default.
- W4313402566 crossrefType "journal-article" @default.
- W4313402566 hasAuthorship W4313402566A5003506051 @default.
- W4313402566 hasAuthorship W4313402566A5007129617 @default.
- W4313402566 hasAuthorship W4313402566A5034211371 @default.
- W4313402566 hasAuthorship W4313402566A5045061206 @default.
- W4313402566 hasAuthorship W4313402566A5072583461 @default.
- W4313402566 hasConcept C154317977 @default.
- W4313402566 hasConcept C159047783 @default.
- W4313402566 hasConcept C167672396 @default.
- W4313402566 hasConcept C202751555 @default.
- W4313402566 hasConcept C203014093 @default.
- W4313402566 hasConcept C2522874641 @default.
- W4313402566 hasConcept C2776090121 @default.
- W4313402566 hasConcept C2777546802 @default.
- W4313402566 hasConcept C2781375147 @default.
- W4313402566 hasConcept C54355233 @default.
- W4313402566 hasConcept C86803240 @default.
- W4313402566 hasConcept C8891405 @default.
- W4313402566 hasConceptScore W4313402566C154317977 @default.
- W4313402566 hasConceptScore W4313402566C159047783 @default.
- W4313402566 hasConceptScore W4313402566C167672396 @default.
- W4313402566 hasConceptScore W4313402566C202751555 @default.
- W4313402566 hasConceptScore W4313402566C203014093 @default.
- W4313402566 hasConceptScore W4313402566C2522874641 @default.
- W4313402566 hasConceptScore W4313402566C2776090121 @default.
- W4313402566 hasConceptScore W4313402566C2777546802 @default.
- W4313402566 hasConceptScore W4313402566C2781375147 @default.
- W4313402566 hasConceptScore W4313402566C54355233 @default.
- W4313402566 hasConceptScore W4313402566C86803240 @default.
- W4313402566 hasConceptScore W4313402566C8891405 @default.
- W4313402566 hasIssue "1_Supplement" @default.
- W4313402566 hasLocation W43134025661 @default.
- W4313402566 hasOpenAccess W4313402566 @default.
- W4313402566 hasPrimaryLocation W43134025661 @default.
- W4313402566 hasRelatedWork W1563157353 @default.
- W4313402566 hasRelatedWork W1964955632 @default.
- W4313402566 hasRelatedWork W1979511395 @default.
- W4313402566 hasRelatedWork W2052483994 @default.
- W4313402566 hasRelatedWork W2063492259 @default.
- W4313402566 hasRelatedWork W2076874973 @default.
- W4313402566 hasRelatedWork W2097166147 @default.
- W4313402566 hasRelatedWork W2104962400 @default.
- W4313402566 hasRelatedWork W2147629250 @default.
- W4313402566 hasRelatedWork W2162191803 @default.
- W4313402566 hasVolume "192" @default.
- W4313402566 isParatext "false" @default.
- W4313402566 isRetracted "false" @default.
- W4313402566 workType "article" @default.