FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313402952> ?p ?o ?g. }

• W4313402952 abstract "Abstract Therapeutic hypothermia improves outcomes following neonatal hypoxic-ischaemic encephalopathy (HIE), reducing cases of death and severe disability such as cerebral palsy compared to normothermia management. However, when cooled children reach early school-age they have cognitive and motor impairments which are associated with underlying alterations to brain structure and white matter connectivity. It is unknown whether these differences in structural connectivity are associated with differences in functional connectivity between cooled children and healthy controls. Resting-state fMRI has been used to characterise static and dynamic functional connectivity in children, both with typical development and those with neurodevelopmental disorders. Previous studies of resting-state brain networks in children with HIE have focussed on the neonatal period. In this study, we used resting-state fMRI to investigate static and dynamic functional connectivity in children aged 6-8 years who were cooled for neonatal HIE without cerebral palsy (n = 22, median age [IQR] 7.08 [6.85-7.52] years), and healthy controls matched for age, sex and socioeconomic status (n = 20, median age [IQR] 6.75 [6.48-7.25] years). Using group independent component analysis, we identified 31 intrinsic functional connectivity networks consistent with those previously reported in children and adults. We found no case-control differences in the spatial maps of these intrinsic connectivity networks. We constructed subject-specific static functional connectivity networks by measuring pairwise Pearson correlations between component time courses, and found no case-control differences in functional connectivity after FDR correction. To study the time-varying organisation of resting-state networks, we used sliding-window correlations and deep clustering to investigate dynamic functional connectivity characteristics. We found k = 4 repetitively occurring functional connectivity states, which exhibited no case-control differences in dwell time, fractional occupancy, or state functional connectivity matrices. In this small cohort, the spatiotemporal characteristics of resting-state brain networks in cooled children without severe disability were too subtle to be differentiated from healthy controls at early school-age, despite underlying differences in brain structure and white matter connectivity, possibly reflecting a level of recovery of healthy resting-state brain function. To our knowledge, this is the first study to investigate resting-state functional connectivity in children with HIE beyond the neonatal period, and the first to investigate dynamic functional connectivity in any children with HIE." @default.
• W4313402952 created "2023-01-06" @default.
• W4313402952 creator A5024052002 @default.
• W4313402952 creator A5028417383 @default.
• W4313402952 creator A5074719764 @default.
• W4313402952 creator A5081264422 @default.
• W4313402952 date "2022-12-18" @default.
• W4313402952 modified "2023-10-10" @default.
• W4313402952 title "Children cooled for neonatal encephalopathy without cerebral palsy retain healthy resting-state static and dynamic functional connectivity" @default.
• W4313402952 cites W1519798359 @default.
• W4313402952 cites W1801278145 @default.
• W4313402952 cites W1830337612 @default.
• W4313402952 cites W1968248619 @default.
• W4313402952 cites W1974586186 @default.
• W4313402952 cites W1976623182 @default.
• W4313402952 cites W1978660262 @default.
• W4313402952 cites W1985327120 @default.
• W4313402952 cites W1989577623 @default.
• W4313402952 cites W1990134753 @default.
• W4313402952 cites W2006096283 @default.
• W4313402952 cites W2006177716 @default.
• W4313402952 cites W2009494091 @default.
• W4313402952 cites W2025768430 @default.
• W4313402952 cites W2033865693 @default.
• W4313402952 cites W2040284184 @default.
• W4313402952 cites W2050343893 @default.
• W4313402952 cites W2052644075 @default.
• W4313402952 cites W2058187841 @default.
• W4313402952 cites W2089648703 @default.
• W4313402952 cites W2091177453 @default.
• W4313402952 cites W2092872141 @default.
• W4313402952 cites W2101219946 @default.
• W4313402952 cites W2108384452 @default.
• W4313402952 cites W2111388536 @default.
• W4313402952 cites W2118366819 @default.
• W4313402952 cites W2123097685 @default.
• W4313402952 cites W2124698428 @default.
• W4313402952 cites W2126693856 @default.
• W4313402952 cites W2132175842 @default.
• W4313402952 cites W2138905229 @default.
• W4313402952 cites W2157106546 @default.
• W4313402952 cites W2157446241 @default.
• W4313402952 cites W2170702893 @default.
• W4313402952 cites W2509822538 @default.
• W4313402952 cites W2513244587 @default.
• W4313402952 cites W2563279629 @default.
• W4313402952 cites W2567460568 @default.
• W4313402952 cites W2745113344 @default.
• W4313402952 cites W2759165456 @default.
• W4313402952 cites W2765741717 @default.
• W4313402952 cites W2794826046 @default.
• W4313402952 cites W2883725317 @default.
• W4313402952 cites W2883890959 @default.
• W4313402952 cites W2895742324 @default.
• W4313402952 cites W2909686801 @default.
• W4313402952 cites W2911167985 @default.
• W4313402952 cites W2925313043 @default.
• W4313402952 cites W2934311525 @default.
• W4313402952 cites W2943494461 @default.
• W4313402952 cites W2952965410 @default.
• W4313402952 cites W2955712477 @default.
• W4313402952 cites W2977883299 @default.
• W4313402952 cites W2981270536 @default.
• W4313402952 cites W2995313551 @default.
• W4313402952 cites W3128800354 @default.
• W4313402952 cites W3134453486 @default.
• W4313402952 cites W3163758630 @default.
• W4313402952 cites W3209227998 @default.
• W4313402952 cites W4210795947 @default.
• W4313402952 cites W4226046520 @default.
• W4313402952 cites W4229439598 @default.
• W4313402952 cites W4288855412 @default.
• W4313402952 cites W4291824666 @default.
• W4313402952 cites W4296887772 @default.
• W4313402952 cites W4307139188 @default.
• W4313402952 cites W4308294765 @default.
• W4313402952 cites W4310957600 @default.
• W4313402952 cites W4321033052 @default.
• W4313402952 doi "https://doi.org/10.1101/2022.12.17.22283576" @default.
• W4313402952 hasPublicationYear "2022" @default.
• W4313402952 type Work @default.
• W4313402952 citedByCount "0" @default.
• W4313402952 crossrefType "posted-content" @default.
• W4313402952 hasAuthorship W4313402952A5024052002 @default.
• W4313402952 hasAuthorship W4313402952A5028417383 @default.
• W4313402952 hasAuthorship W4313402952A5074719764 @default.
• W4313402952 hasAuthorship W4313402952A5081264422 @default.
• W4313402952 hasBestOaLocation W43134029521 @default.
• W4313402952 hasConcept C126322002 @default.
• W4313402952 hasConcept C126838900 @default.
• W4313402952 hasConcept C143409427 @default.
• W4313402952 hasConcept C15744967 @default.
• W4313402952 hasConcept C169760540 @default.
• W4313402952 hasConcept C169900460 @default.
• W4313402952 hasConcept C187212893 @default.
• W4313402952 hasConcept C2778621155 @default.
• W4313402952 hasConcept C2779421357 @default.
• W4313402952 hasConcept C2781192897 @default.
• W4313402952 hasConcept C3018011982 @default.
• W4313402952 hasConcept C66324658 @default.

• next