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- W4313403776 abstract "Abstract Diabetes mellitus and cerebral infarction are two major diseases increasing with aging that threaten human health，Oxidative stress is the main cause of diabetes mellitus and acute cerebral ischemic injury.However,It has not been clear how changes in oxidative stress of peripheral lymphocytes affect GSK-3 in DM patients with cerebral infarction.Here,186 patients with DM were enrolled and randomly assigned to DM group(n=89) and DM with cerebral infarction (DM+CI) group (n=97).Eighty-one patients with cerebral infarction were selected as cerebral infarction (CI) group and eighty normal subjects over 50 years were selected as the control group.Superoxide dismutase (SOD) activity, glutathione peroxidase (GSH-Px) activity,and malondialdehyde (MDA) content in serum were determined by colorimetric assays.Phosphorylation of GSK-3βwas measured by enzyme-linked immunosorbent assay (ELISA).It was found that compared with the control group,the SOD activity and the GSH-Px activity in DM+CI group were decreased,accompanied by higher MDA content.Phosphorylation of GSK-3βwas continuously decreased.Moreover,SOD activity,GSH-P x activity and phosphorylation of GSK-3βin DM +CI group was decreased compared to the CI group and the DM group,while MDA content was increased.We demonstrated that compared with DM and CI group, DM patients with cerebral infarction had a more obvious oxidative stress response and severe oxidative damage. The increased GSK-3βactivity, causing more severe cellular damage, may be one of the mechanisms by which oxidative stress causes DM with cerebral infarction. which might provide a diagnostic and therapeutic approach for DM patients with cerebral infarction." @default.
- W4313403776 created "2023-01-06" @default.
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- W4313403776 date "2022-12-19" @default.
- W4313403776 modified "2023-10-12" @default.
- W4313403776 title "Oxidative Stress regulates glycogen synthase kinase-3 in Lymphocytes of Diabetes Mellitus Patients with cerebral infarction" @default.
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- W4313403776 doi "https://doi.org/10.21203/rs.3.rs-2368783/v1" @default.
- W4313403776 hasPublicationYear "2022" @default.
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