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- W4313403931 endingPage "121285" @default.
- W4313403931 startingPage "121285" @default.
- W4313403931 abstract "Polycystic ovaries (PCO) is a hormonal disorder that is a leading cause of infertility. The formation of multiple persistent cysts and hormonal imbalance are hallmarks of PCO. Recent clinical studies reported a beneficial effect of the ketogenic diet (KD; high-fat, low-carbohydrate) on PCO. The aim of this study was to investigate the effect of the KD alone and in combination with metformin on letrozole-induced PCO in female rats.Female rats were grouped into control and PCO (letrozole; 1 mg/kg for 21 days). The PCO group was subdivided into PCO (non-treated), PCO-metformin (300 mg/kg), PCO rats fed with KD only, and PCO rats treated with metformin and fed with KD. All groups continued to receive letrozole during the 21-day treatment period. At the end of the experiment, serum and ovaries were collected for further analysis.The untreated-PCO rats showed increased testosterone, LH/FSH ratio, and ovary weights. Disturbed apoptosis and proliferation balance were evident as a low caspase-3 activation and proliferating cell nuclear antigen expression and increased TGF-β expression. The KD improved the letrozole-induced effects, which was comparable to the effect of metformin. Combining the KD with metformin treatment additively enhanced the metformin effect.Our results indicate that the KD has a protective role against PCO in rats, especially when combined with metformin. This study reveals a potential therapeutic role of the KD in PCO, which could prompt valuable future clinical applications." @default.
- W4313403931 created "2023-01-06" @default.
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- W4313403931 creator A5091596289 @default.
- W4313403931 date "2023-01-01" @default.
- W4313403931 modified "2023-10-16" @default.
- W4313403931 title "Ketogenic diet restores hormonal, apoptotic/proliferative balance and enhances the effect of metformin on a letrozole-induced polycystic ovary model in rats" @default.
- W4313403931 cites W1558439475 @default.
- W4313403931 cites W1567045482 @default.
- W4313403931 cites W1636022999 @default.
- W4313403931 cites W1933209701 @default.
- W4313403931 cites W1966223430 @default.
- W4313403931 cites W1968409213 @default.
- W4313403931 cites W1970226275 @default.
- W4313403931 cites W1976383821 @default.
- W4313403931 cites W1977280433 @default.
- W4313403931 cites W1977681402 @default.
- W4313403931 cites W1981529098 @default.
- W4313403931 cites W1982050083 @default.
- W4313403931 cites W1991802772 @default.
- W4313403931 cites W1992989336 @default.
- W4313403931 cites W1993409478 @default.
- W4313403931 cites W2005172042 @default.
- W4313403931 cites W2007816906 @default.
- W4313403931 cites W2014046105 @default.
- W4313403931 cites W201653061 @default.
- W4313403931 cites W2031320248 @default.
- W4313403931 cites W2033021374 @default.
- W4313403931 cites W2037342776 @default.
- W4313403931 cites W2041946095 @default.
- W4313403931 cites W2042889685 @default.
- W4313403931 cites W2045776429 @default.
- W4313403931 cites W2053054955 @default.
- W4313403931 cites W2057313063 @default.
- W4313403931 cites W2067842066 @default.
- W4313403931 cites W2088700698 @default.
- W4313403931 cites W2101316067 @default.
- W4313403931 cites W2118090983 @default.
- W4313403931 cites W2129162444 @default.
- W4313403931 cites W2133184757 @default.
- W4313403931 cites W2144280418 @default.
- W4313403931 cites W2146577073 @default.
- W4313403931 cites W2148353951 @default.
- W4313403931 cites W2160329305 @default.
- W4313403931 cites W2160472557 @default.
- W4313403931 cites W2167664512 @default.
- W4313403931 cites W2180762163 @default.
- W4313403931 cites W2257288101 @default.
- W4313403931 cites W2277946142 @default.
- W4313403931 cites W2339818293 @default.
- W4313403931 cites W2401156097 @default.
- W4313403931 cites W2487273669 @default.
- W4313403931 cites W2528009933 @default.
- W4313403931 cites W2558718156 @default.
- W4313403931 cites W2571743320 @default.
- W4313403931 cites W2592647536 @default.
- W4313403931 cites W2593574554 @default.
- W4313403931 cites W2606246198 @default.
- W4313403931 cites W2680582898 @default.
- W4313403931 cites W2763108216 @default.
- W4313403931 cites W2765260359 @default.
- W4313403931 cites W2768768130 @default.
- W4313403931 cites W2798130906 @default.
- W4313403931 cites W2804460705 @default.
- W4313403931 cites W2811423579 @default.
- W4313403931 cites W2885481960 @default.
- W4313403931 cites W2885650023 @default.
- W4313403931 cites W2886863501 @default.
- W4313403931 cites W2890729739 @default.
- W4313403931 cites W2891202838 @default.
- W4313403931 cites W2900967868 @default.
- W4313403931 cites W2920947723 @default.
- W4313403931 cites W2950491201 @default.
- W4313403931 cites W2954291267 @default.
- W4313403931 cites W2963985015 @default.
- W4313403931 cites W2965696960 @default.
- W4313403931 cites W2973512157 @default.
- W4313403931 cites W2980624284 @default.
- W4313403931 cites W2999424311 @default.
- W4313403931 cites W3010567443 @default.
- W4313403931 cites W3029449675 @default.
- W4313403931 cites W3074753105 @default.
- W4313403931 cites W3086404653 @default.
- W4313403931 cites W3095111475 @default.
- W4313403931 cites W3122815735 @default.
- W4313403931 cites W3126379268 @default.
- W4313403931 cites W3126381753 @default.
- W4313403931 cites W3128343902 @default.