Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313404740> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4313404740 endingPage "51.05" @default.
- W4313404740 startingPage "51.05" @default.
- W4313404740 abstract "Abstract Caspase-1 is a key effector molecule involved in inflammasome activation and has a well-established role in restricting the growth of intracellular pathogens like Salmonella by triggering a form of cell death called pyroptosis. Here we reveal a non-canonical, cell death independent role for caspase-1 in controlling the transcriptional state and drug resistance of intracellular Salmonella. Using Pathogen-sequencing, a method for sensitive transcriptional profiling of miniscule numbers of intracellular bacteria from infected macrophages, we show that that caspase-1 regulates key processes involved in survival and antimicrobial susceptibility of intracellular Salmonella. Host caspase-1 increased susceptibility of Salmonella to endogenous cationic antimicrobial peptides, as well as to a cationic polypeptide antibiotic used as a last-line drug in Gram-negative bacterial infections. These effects of caspase-1 were independent of its enzymatic activity but dependent on its ability to repress activation of a two-component signal transduction system in intracellular bacteria. These effects were also independent of caspase-11. Our data suggest a “backup” role for caspase-1 in dampening antimicrobial resistance of intracellular Salmonella which evade initial innate immune detection and restriction by caspase-1. These findings also reveal the role of a key innate immune effector in altering pathogen physiology, broadening our view of host-pathogen crosstalk with possible implications for targeting caspase-1 in host-directed therapy to combat antimicrobial resistance. Supported by grant from NIH (R01 AI155685-A1 ) and AAI Careers in Immunology Fellowship (2018-2019)" @default.
- W4313404740 created "2023-01-06" @default.
- W4313404740 creator A5005287667 @default.
- W4313404740 creator A5010883050 @default.
- W4313404740 creator A5012430080 @default.
- W4313404740 creator A5014997939 @default.
- W4313404740 creator A5022240667 @default.
- W4313404740 creator A5034022428 @default.
- W4313404740 creator A5072790987 @default.
- W4313404740 creator A5090998899 @default.
- W4313404740 date "2022-05-01" @default.
- W4313404740 modified "2023-10-16" @default.
- W4313404740 title "A non-canonical role of caspase-1 in regulating bacterial physiology and antimicrobial resistance" @default.
- W4313404740 doi "https://doi.org/10.4049/jimmunol.208.supp.51.05" @default.
- W4313404740 hasPublicationYear "2022" @default.
- W4313404740 type Work @default.
- W4313404740 citedByCount "0" @default.
- W4313404740 crossrefType "journal-article" @default.
- W4313404740 hasAuthorship W4313404740A5005287667 @default.
- W4313404740 hasAuthorship W4313404740A5010883050 @default.
- W4313404740 hasAuthorship W4313404740A5012430080 @default.
- W4313404740 hasAuthorship W4313404740A5014997939 @default.
- W4313404740 hasAuthorship W4313404740A5022240667 @default.
- W4313404740 hasAuthorship W4313404740A5034022428 @default.
- W4313404740 hasAuthorship W4313404740A5072790987 @default.
- W4313404740 hasAuthorship W4313404740A5090998899 @default.
- W4313404740 hasConcept C136449434 @default.
- W4313404740 hasConcept C139964883 @default.
- W4313404740 hasConcept C153726182 @default.
- W4313404740 hasConcept C17172800 @default.
- W4313404740 hasConcept C190283241 @default.
- W4313404740 hasConcept C203014093 @default.
- W4313404740 hasConcept C2776460866 @default.
- W4313404740 hasConcept C2776914184 @default.
- W4313404740 hasConcept C2777209026 @default.
- W4313404740 hasConcept C2781065037 @default.
- W4313404740 hasConcept C31573885 @default.
- W4313404740 hasConcept C4937899 @default.
- W4313404740 hasConcept C51785407 @default.
- W4313404740 hasConcept C523546767 @default.
- W4313404740 hasConcept C540938839 @default.
- W4313404740 hasConcept C54355233 @default.
- W4313404740 hasConcept C55493867 @default.
- W4313404740 hasConcept C79879829 @default.
- W4313404740 hasConcept C86803240 @default.
- W4313404740 hasConcept C8891405 @default.
- W4313404740 hasConcept C89423630 @default.
- W4313404740 hasConcept C95444343 @default.
- W4313404740 hasConcept C98424977 @default.
- W4313404740 hasConceptScore W4313404740C136449434 @default.
- W4313404740 hasConceptScore W4313404740C139964883 @default.
- W4313404740 hasConceptScore W4313404740C153726182 @default.
- W4313404740 hasConceptScore W4313404740C17172800 @default.
- W4313404740 hasConceptScore W4313404740C190283241 @default.
- W4313404740 hasConceptScore W4313404740C203014093 @default.
- W4313404740 hasConceptScore W4313404740C2776460866 @default.
- W4313404740 hasConceptScore W4313404740C2776914184 @default.
- W4313404740 hasConceptScore W4313404740C2777209026 @default.
- W4313404740 hasConceptScore W4313404740C2781065037 @default.
- W4313404740 hasConceptScore W4313404740C31573885 @default.
- W4313404740 hasConceptScore W4313404740C4937899 @default.
- W4313404740 hasConceptScore W4313404740C51785407 @default.
- W4313404740 hasConceptScore W4313404740C523546767 @default.
- W4313404740 hasConceptScore W4313404740C540938839 @default.
- W4313404740 hasConceptScore W4313404740C54355233 @default.
- W4313404740 hasConceptScore W4313404740C55493867 @default.
- W4313404740 hasConceptScore W4313404740C79879829 @default.
- W4313404740 hasConceptScore W4313404740C86803240 @default.
- W4313404740 hasConceptScore W4313404740C8891405 @default.
- W4313404740 hasConceptScore W4313404740C89423630 @default.
- W4313404740 hasConceptScore W4313404740C95444343 @default.
- W4313404740 hasConceptScore W4313404740C98424977 @default.
- W4313404740 hasIssue "1_Supplement" @default.
- W4313404740 hasLocation W43134047401 @default.
- W4313404740 hasOpenAccess W4313404740 @default.
- W4313404740 hasPrimaryLocation W43134047401 @default.
- W4313404740 hasRelatedWork W1989551786 @default.
- W4313404740 hasRelatedWork W259345450 @default.
- W4313404740 hasRelatedWork W2936704425 @default.
- W4313404740 hasRelatedWork W3155656598 @default.
- W4313404740 hasRelatedWork W325437686 @default.
- W4313404740 hasRelatedWork W4211249806 @default.
- W4313404740 hasRelatedWork W4224863631 @default.
- W4313404740 hasRelatedWork W4282937366 @default.
- W4313404740 hasRelatedWork W4310525957 @default.
- W4313404740 hasRelatedWork W4313404740 @default.
- W4313404740 hasVolume "208" @default.
- W4313404740 isParatext "false" @default.
- W4313404740 isRetracted "false" @default.
- W4313404740 workType "article" @default.