Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313404815> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313404815 endingPage "54.13" @default.
- W4313404815 startingPage "54.13" @default.
- W4313404815 abstract "Abstract Neurorestoration following ischemic stroke is regulated by a complex interaction between the resident glial cells and the immune cells infiltrated to the brain. Using transient middle cerebral artery occlusion (tMCAO), it was shown that both monocytes and regulatory T cells (Tregs) play a critical role in facilitating neurorestoration following ischemic injury of the brain. However, the underlying mechanisms are not well-understood. Importantly, it is unclear whether the neurorestorative effect of monocytes and Tregs require their cognate interaction. The goal of this study is to investigate the interplay between monocytes and Tregs in facilitating brain recovery following ischemic injury. Using mouse tMCAO model, we found that 1) Monocytes were present in the brain both at the sub-acute (day 3) and chronic phases (day 14) following tMCAO, whereas Tregs were significantly increased in the brain only at the chronic phase. 2) During the chronic phase, monocytes and Tregs interacted within the glial scar. 3) CCR2, which controls monocyte trafficking, was expressed in monocytes but not in Tregs, but the number of both monocytes and Tregs were substantially reduced following tMCAO when CCR2 was deleted. 4) CCR2-deficient mice had a reduced survival rate and a larger area of glia scar during the chronic phase post-stroke compared to CCR2-sufficient mice. 5) Tregs in the cervical lymph nodes expressed CCR4 following tMCAO, which is known to control Treg trafficking. 6) Monocytes express CCR4 ligands, CCL17 and CCL22, during differentiation into monocyte-derived cells (MDCs) in vitro. Thus, our data demonstrate that monocytes may exert their neuroprotective via the regulation of Treg trafficking and/or expansion following ischemic stroke. This work was supported by NIH grants P20GM109098 and R21NS125056 to Edwin Wan. Kelly Monaghan was supported through The American Association of Immunologists Careers in Immunology Fellowship Program." @default.
- W4313404815 created "2023-01-06" @default.
- W4313404815 creator A5056379207 @default.
- W4313404815 creator A5057831501 @default.
- W4313404815 creator A5070048124 @default.
- W4313404815 creator A5074950160 @default.
- W4313404815 date "2022-05-01" @default.
- W4313404815 modified "2023-09-28" @default.
- W4313404815 title "A potential monocyte-regulatory T cell axis in neurorestoration following ischemic stroke" @default.
- W4313404815 doi "https://doi.org/10.4049/jimmunol.208.supp.54.13" @default.
- W4313404815 hasPublicationYear "2022" @default.
- W4313404815 type Work @default.
- W4313404815 citedByCount "0" @default.
- W4313404815 crossrefType "journal-article" @default.
- W4313404815 hasAuthorship W4313404815A5056379207 @default.
- W4313404815 hasAuthorship W4313404815A5057831501 @default.
- W4313404815 hasAuthorship W4313404815A5070048124 @default.
- W4313404815 hasAuthorship W4313404815A5074950160 @default.
- W4313404815 hasConcept C127413603 @default.
- W4313404815 hasConcept C12823836 @default.
- W4313404815 hasConcept C13373296 @default.
- W4313404815 hasConcept C203014093 @default.
- W4313404815 hasConcept C206615009 @default.
- W4313404815 hasConcept C2775866117 @default.
- W4313404815 hasConcept C2776914184 @default.
- W4313404815 hasConcept C2779830541 @default.
- W4313404815 hasConcept C2780645631 @default.
- W4313404815 hasConcept C2781184567 @default.
- W4313404815 hasConcept C502942594 @default.
- W4313404815 hasConcept C71924100 @default.
- W4313404815 hasConcept C78519656 @default.
- W4313404815 hasConcept C8891405 @default.
- W4313404815 hasConceptScore W4313404815C127413603 @default.
- W4313404815 hasConceptScore W4313404815C12823836 @default.
- W4313404815 hasConceptScore W4313404815C13373296 @default.
- W4313404815 hasConceptScore W4313404815C203014093 @default.
- W4313404815 hasConceptScore W4313404815C206615009 @default.
- W4313404815 hasConceptScore W4313404815C2775866117 @default.
- W4313404815 hasConceptScore W4313404815C2776914184 @default.
- W4313404815 hasConceptScore W4313404815C2779830541 @default.
- W4313404815 hasConceptScore W4313404815C2780645631 @default.
- W4313404815 hasConceptScore W4313404815C2781184567 @default.
- W4313404815 hasConceptScore W4313404815C502942594 @default.
- W4313404815 hasConceptScore W4313404815C71924100 @default.
- W4313404815 hasConceptScore W4313404815C78519656 @default.
- W4313404815 hasConceptScore W4313404815C8891405 @default.
- W4313404815 hasIssue "1_Supplement" @default.
- W4313404815 hasLocation W43134048151 @default.
- W4313404815 hasOpenAccess W4313404815 @default.
- W4313404815 hasPrimaryLocation W43134048151 @default.
- W4313404815 hasRelatedWork W1564896302 @default.
- W4313404815 hasRelatedWork W1989199068 @default.
- W4313404815 hasRelatedWork W2010472544 @default.
- W4313404815 hasRelatedWork W2052554962 @default.
- W4313404815 hasRelatedWork W2075871178 @default.
- W4313404815 hasRelatedWork W2123811618 @default.
- W4313404815 hasRelatedWork W2362007119 @default.
- W4313404815 hasRelatedWork W2809365397 @default.
- W4313404815 hasRelatedWork W4229032869 @default.
- W4313404815 hasRelatedWork W4313383249 @default.
- W4313404815 hasVolume "208" @default.
- W4313404815 isParatext "false" @default.
- W4313404815 isRetracted "false" @default.
- W4313404815 workType "article" @default.