Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313404826> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4313404826 endingPage "58.03" @default.
- W4313404826 startingPage "58.03" @default.
- W4313404826 abstract "Abstract Commensals actively contribute to homeostasis in the skin, but a perturbation of the skin bacteria leading to a dysbiosis often promotes increased inflammation. How regulatory mechanisms control the degree of inflammation associated with a dysbiosis is unclear. Here we used a Staphylococcus aureus isolate from Leishmania braziliensis patients to study the regulation of the host immune response in the skin and its consequence during cutaneous leishmaniasis. Topical colonization with S. aureus induced type 17 responses with minimal skin inflammation. Analysis of Foxp3+ Treg cells revealed IL-6 dependent accumulation of Blimp-1 expressing RORgt+Foxp3+ Treg cells in colonized skin, and that may play a protective regulatory role. To test this, we depleted Foxp3+ Treg cells, which resulted in significant inflammation and a higher bacterial burden on the skin. Additionally, there was some decrease in IL-17 responses, but a significant increase in the IFN-γ production from CD4+ T cells. Moreover, blockade of IFN-γ in Foxp3+ Treg depleted mice restored commensal immunity, barrier function and inflammation. In mice infected with L. braziliensis, depletion of Foxp3+ T cells had a minimal effect on lesion development. However, depletion of Foxp3+ T cells in S. aureus colonized and L. braziliensis infected mice resulted in significantly more inflammation and bacterial burden than control mice without altering the parasite burden. Taken together, we identified a role for Foxp3+ Treg cells in limiting inflammatory responses to skin bacteria by controlling production of IFN-γ by CD4+ T cells." @default.
- W4313404826 created "2023-01-06" @default.
- W4313404826 creator A5004603001 @default.
- W4313404826 creator A5015047591 @default.
- W4313404826 creator A5031648715 @default.
- W4313404826 creator A5062220434 @default.
- W4313404826 creator A5066166717 @default.
- W4313404826 creator A5089024927 @default.
- W4313404826 date "2022-05-01" @default.
- W4313404826 modified "2023-09-25" @default.
- W4313404826 title "Regulatory T cells control Th1 responses to sustain bacterial immunity and skin barrier function" @default.
- W4313404826 doi "https://doi.org/10.4049/jimmunol.208.supp.58.03" @default.
- W4313404826 hasPublicationYear "2022" @default.
- W4313404826 type Work @default.
- W4313404826 citedByCount "0" @default.
- W4313404826 crossrefType "journal-article" @default.
- W4313404826 hasAuthorship W4313404826A5004603001 @default.
- W4313404826 hasAuthorship W4313404826A5015047591 @default.
- W4313404826 hasAuthorship W4313404826A5031648715 @default.
- W4313404826 hasAuthorship W4313404826A5062220434 @default.
- W4313404826 hasAuthorship W4313404826A5066166717 @default.
- W4313404826 hasAuthorship W4313404826A5089024927 @default.
- W4313404826 hasConcept C136764020 @default.
- W4313404826 hasConcept C203014093 @default.
- W4313404826 hasConcept C2776090121 @default.
- W4313404826 hasConcept C2776555147 @default.
- W4313404826 hasConcept C2776914184 @default.
- W4313404826 hasConcept C2777165150 @default.
- W4313404826 hasConcept C2778296632 @default.
- W4313404826 hasConcept C2778702967 @default.
- W4313404826 hasConcept C2779341262 @default.
- W4313404826 hasConcept C2779727006 @default.
- W4313404826 hasConcept C2780599195 @default.
- W4313404826 hasConcept C2781092759 @default.
- W4313404826 hasConcept C41008148 @default.
- W4313404826 hasConcept C539455810 @default.
- W4313404826 hasConcept C71928629 @default.
- W4313404826 hasConcept C79484868 @default.
- W4313404826 hasConcept C86803240 @default.
- W4313404826 hasConcept C8891405 @default.
- W4313404826 hasConcept C89423630 @default.
- W4313404826 hasConceptScore W4313404826C136764020 @default.
- W4313404826 hasConceptScore W4313404826C203014093 @default.
- W4313404826 hasConceptScore W4313404826C2776090121 @default.
- W4313404826 hasConceptScore W4313404826C2776555147 @default.
- W4313404826 hasConceptScore W4313404826C2776914184 @default.
- W4313404826 hasConceptScore W4313404826C2777165150 @default.
- W4313404826 hasConceptScore W4313404826C2778296632 @default.
- W4313404826 hasConceptScore W4313404826C2778702967 @default.
- W4313404826 hasConceptScore W4313404826C2779341262 @default.
- W4313404826 hasConceptScore W4313404826C2779727006 @default.
- W4313404826 hasConceptScore W4313404826C2780599195 @default.
- W4313404826 hasConceptScore W4313404826C2781092759 @default.
- W4313404826 hasConceptScore W4313404826C41008148 @default.
- W4313404826 hasConceptScore W4313404826C539455810 @default.
- W4313404826 hasConceptScore W4313404826C71928629 @default.
- W4313404826 hasConceptScore W4313404826C79484868 @default.
- W4313404826 hasConceptScore W4313404826C86803240 @default.
- W4313404826 hasConceptScore W4313404826C8891405 @default.
- W4313404826 hasConceptScore W4313404826C89423630 @default.
- W4313404826 hasIssue "1_Supplement" @default.
- W4313404826 hasLocation W43134048261 @default.
- W4313404826 hasOpenAccess W4313404826 @default.
- W4313404826 hasPrimaryLocation W43134048261 @default.
- W4313404826 hasRelatedWork W1569971301 @default.
- W4313404826 hasRelatedWork W1901555156 @default.
- W4313404826 hasRelatedWork W1994875174 @default.
- W4313404826 hasRelatedWork W1997714882 @default.
- W4313404826 hasRelatedWork W2024183797 @default.
- W4313404826 hasRelatedWork W2078792455 @default.
- W4313404826 hasRelatedWork W2120509159 @default.
- W4313404826 hasRelatedWork W2142220843 @default.
- W4313404826 hasRelatedWork W2159048228 @default.
- W4313404826 hasRelatedWork W4313404826 @default.
- W4313404826 hasVolume "208" @default.
- W4313404826 isParatext "false" @default.
- W4313404826 isRetracted "false" @default.
- W4313404826 workType "article" @default.