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- W4313404859 abstract "Abstract It has been established that cell proliferation and survival activities can be controlled according to metabolic resources in inflammation. However, it is not clear how T cell-mediated inflammatory immune responses in rheumatoid arthritis (RA) affect the activity and regulation of inflammatory cells by meeting biosynthesis and bioenergy requirements. This study evaluated the effect of serotonin-derived metabolite 5-Hydroxyndole-3-acetic acid (5-HIAA) on the increase in glutamate oxaloacetate transaminase 1 (GOT1) by the differentiation of Th1, Th17, or Th1/17 cells. The differentiation of Th1, Th17, or Th1/17 cells increased GOT1 and showed that GOT1 promotes the differentiation of Th1, Th17, or Th1/17 cells. Conversely, selective inhibition of GOT1 using 5-HIAA blocked the differentiation of Th1, Th17, or Th1/17 cells. Furthermore, inhibition of GOT1 using 5-HIAA ameliorated RA through up-regulation of regulatory T cells (Foxp3+CD4+), suppression of pro-inflammatory cytokines, and inhibition of Th1/17 responses in mouse joints. Therefore, targeting glutamate-dependent metabolic pathways would be an effective therapeutic strategy for rheumatoid arthritis and a wide spectrum of autoimmune diseases. Supported by 21st Century Medical Science Creative Human Resource Development Center" @default.
- W4313404859 created "2023-01-06" @default.
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- W4313404859 date "2022-05-01" @default.
- W4313404859 modified "2023-09-25" @default.
- W4313404859 title "5-Hydroxyndole-3-acetic acid suppresses activation of glutamate oxaloacetate transaminase 1 linked to Th1/17 cell differentiation and ameliorates rheumatoid arthritis" @default.
- W4313404859 doi "https://doi.org/10.4049/jimmunol.208.supp.56.16" @default.
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