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- W4313404892 abstract "Abstract Memory T cells cause faster and more effective elimination of pathogens during reinfection by the rapid production of effector T cells. Worldwide, the leading cause of death among children and infants is infection, partly due to under-developed T cell memory populations commonly seen in infants. In the context of biomedical research, the specific pathogen-free (SPF) facilities research animals are housed in further the deficit of memory T cells, as it is known that adult mice housed in SPF facilities have few memory T cells, but that exposure to normal microbial experiences (NME) replenishes this population of cells. This phenomenon, though, has not been investigated in infants. Therefore, we aimed to investigate how NME influences infant memory T cell commitment to reveal novel insights into natural mammalian immune development. At various time points, the trajectory of infant immune maturation of age-matched SPF and NME (pups birthed and raised in an environment exposed to NME) mice were examined using flow cytometry. We observed significant increases in both the number and frequency of memory T cell subsets (CD8+ and CD4+ Tcm and Tem cells) at all time points in pups exposed to NME. We also observed increased serum concentrations of cytokines required for memory T cell differentiation and survival (IL-7 and IL-15) in NME pups. These data support the hypothesis that NME accelerates the maturation of the memory T cell compartment in infant mice. We predict this more mature memory T cell compartment may contribute to improved immunity to novel infections. Our ongoing experiments test this hypothesis using a Listeria monocytogenes challenge model." @default.
- W4313404892 created "2023-01-06" @default.
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- W4313404892 date "2022-05-01" @default.
- W4313404892 modified "2023-09-25" @default.
- W4313404892 title "Normal microbial experiences accelerate memory T cell compartment maturation in infants" @default.
- W4313404892 doi "https://doi.org/10.4049/jimmunol.208.supp.57.09" @default.
- W4313404892 hasPublicationYear "2022" @default.
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