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• W4313405182 abstract "Sheep exhibit a distinct estrous cycle that includes four different phases: proestrus, estrus, late estrus, and luteal phase. As the estrous cycle repeats, follicular development regularly alternates. We thus investigated ovarian transcriptome data from each of the four phases using weighted gene co-expression network analysis (WGCNA) to identify modules, pathways, and genes essential to follicle growth and development. We clustered mRNA and long non-coding RNA (lncRNA) into different modules by WGCNA, and calculated correlation coefficients between genes and Stages of the estrous cycle. Co-expression of the black module (cor = 0.81, P &lt;0.001) and the yellow module (cor = 0.61, P &lt;0.04) was found to be critical for follicle growth and development. A total of 2066 genes comprising the black and yellow modules was used for functional enrichment. The results reveal that these genes are mainly enriched in Cell cycle, PI3K-Akt signaling pathway, Oocyte meiosis, Apoptosis, and other important signaling pathways. We also identified seven hub genes ( BUB1B, MAD2L1, ASPM, HSD3B1, WDHD1, CENPA , and MXI1 ) that may play a role in follicle development. Our study may provide several important new markers allowing in depth exploration of the genetic basis for multiparous reproduction in sheep." @default.
• W4313405182 created "2023-01-06" @default.
• W4313405182 creator A5025690115 @default.
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• W4313405182 date "2022-12-19" @default.
• W4313405182 modified "2023-10-16" @default.
• W4313405182 title "Identification of hub genes associated with follicle development in multiple births sheep by WGCNA" @default.
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• W4313405182 doi "https://doi.org/10.3389/fvets.2022.1057282" @default.
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