FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313405586> ?p ?o ?g. }

• W4313405586 endingPage "1109" @default.
• W4313405586 startingPage "1096" @default.
• W4313405586 abstract "Abstract Surface modifications can be applied to biomaterials to alter the various surface properties that influence protein‐material interactions and the cellular response. The plasma protein fetuin‐A has been found to adsorb to many biomaterials but details of its interactions with polydimethylsiloxane (PDMS) and roles in regulating the immune response are not clear. Here, PDMS modifications are achieved by altering the ratio of PDMS formulations to control elastic modulus, and by coating PDMS with polydopamine (PDA) to attach fetuin‐A. Surface characterization confirmed that altering the PDMS formulation changed the elastic modulus without affecting surface wetting properties. Surface roughness was measured using atomic force microscopy and surface chemistry was determined using X‐ray photoelectron spectroscopy, with only minor changes detected on the softest samples. PDA deposition on PDMS was confirmed and contact angle measurements demonstrated an increase in hydrophilicity. Fetuin‐A adsorption was influenced by the PDMS formulations, adsorption changed in a competitive plasma environment, and PDA was able to immobilize the greatest amount of fetuin‐A. The inflammatory effects of fetuin‐A were investigated, and data suggests that the elastic modulus influences cytokine secretion from macrophages at certain timepoints, a result likely due to varied protein amounts and orientations/conformations in response to material stiffness. The addition of a PDA layer demonstrated the potentially cytokine mitigating effect upon fetuin‐A immobilization when compared to unmodified PDMS samples. The results provide new insight into the interactions of fetuin‐A with PDMS and PDA, and the potential immune regulatory properties of fetuin‐A modified materials." @default.
• W4313405586 created "2023-01-06" @default.
• W4313405586 creator A5016494060 @default.
• W4313405586 creator A5037271271 @default.
• W4313405586 date "2023-01-02" @default.
• W4313405586 modified "2023-10-12" @default.
• W4313405586 title "Fetuin‐<scp>A</scp> adsorption to tunable polydimethylsiloxane and subsequent macrophage response" @default.
• W4313405586 cites W1489759013 @default.
• W4313405586 cites W1973035908 @default.
• W4313405586 cites W1979712769 @default.
• W4313405586 cites W1980845037 @default.
• W4313405586 cites W1986031245 @default.
• W4313405586 cites W1986821827 @default.
• W4313405586 cites W1995063875 @default.
• W4313405586 cites W1996833161 @default.
• W4313405586 cites W1999460433 @default.
• W4313405586 cites W2021703335 @default.
• W4313405586 cites W2024181247 @default.
• W4313405586 cites W2025915756 @default.
• W4313405586 cites W2031732057 @default.
• W4313405586 cites W2035900052 @default.
• W4313405586 cites W2038689279 @default.
• W4313405586 cites W2038846800 @default.
• W4313405586 cites W2043948526 @default.
• W4313405586 cites W2045036509 @default.
• W4313405586 cites W2048277375 @default.
• W4313405586 cites W2060613028 @default.
• W4313405586 cites W2062539028 @default.
• W4313405586 cites W2064544018 @default.
• W4313405586 cites W2067282815 @default.
• W4313405586 cites W2068343592 @default.
• W4313405586 cites W2073201063 @default.
• W4313405586 cites W2083606646 @default.
• W4313405586 cites W2084919802 @default.
• W4313405586 cites W2088176919 @default.
• W4313405586 cites W2088729609 @default.
• W4313405586 cites W2091929881 @default.
• W4313405586 cites W2097503680 @default.
• W4313405586 cites W2125774336 @default.
• W4313405586 cites W2148328620 @default.
• W4313405586 cites W2159146836 @default.
• W4313405586 cites W2167455623 @default.
• W4313405586 cites W2167830630 @default.
• W4313405586 cites W2179951052 @default.
• W4313405586 cites W2197106873 @default.
• W4313405586 cites W2316852569 @default.
• W4313405586 cites W2329535017 @default.
• W4313405586 cites W2516547862 @default.
• W4313405586 cites W2576068206 @default.
• W4313405586 cites W2679742130 @default.
• W4313405586 cites W2752494835 @default.
• W4313405586 cites W2754538438 @default.
• W4313405586 cites W2760132299 @default.
• W4313405586 cites W2795901967 @default.
• W4313405586 cites W2799932713 @default.
• W4313405586 cites W2820380293 @default.
• W4313405586 cites W2902051451 @default.
• W4313405586 cites W2920302920 @default.
• W4313405586 cites W2934883208 @default.
• W4313405586 cites W2952534170 @default.
• W4313405586 cites W3188265373 @default.
• W4313405586 cites W3212137076 @default.
• W4313405586 cites W806028833 @default.
• W4313405586 doi "https://doi.org/10.1002/jbm.a.37491" @default.
• W4313405586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36592125" @default.
• W4313405586 hasPublicationYear "2023" @default.
• W4313405586 type Work @default.
• W4313405586 citedByCount "1" @default.
• W4313405586 countsByYear W43134055862023 @default.
• W4313405586 crossrefType "journal-article" @default.
• W4313405586 hasAuthorship W4313405586A5016494060 @default.
• W4313405586 hasAuthorship W4313405586A5037271271 @default.
• W4313405586 hasConcept C107365816 @default.
• W4313405586 hasConcept C108625454 @default.
• W4313405586 hasConcept C127413603 @default.
• W4313405586 hasConcept C134514944 @default.
• W4313405586 hasConcept C150394285 @default.
• W4313405586 hasConcept C159985019 @default.
• W4313405586 hasConcept C178790620 @default.
• W4313405586 hasConcept C185592680 @default.
• W4313405586 hasConcept C192562407 @default.
• W4313405586 hasConcept C2778541144 @default.
• W4313405586 hasConcept C2779849746 @default.
• W4313405586 hasConcept C42360764 @default.
• W4313405586 hasConcept C43486711 @default.
• W4313405586 hasConcept C521977710 @default.
• W4313405586 hasConcept C55493867 @default.
• W4313405586 hasConcept C6556556 @default.
• W4313405586 hasConcept C88001094 @default.
• W4313405586 hasConceptScore W4313405586C107365816 @default.
• W4313405586 hasConceptScore W4313405586C108625454 @default.
• W4313405586 hasConceptScore W4313405586C127413603 @default.
• W4313405586 hasConceptScore W4313405586C134514944 @default.
• W4313405586 hasConceptScore W4313405586C150394285 @default.
• W4313405586 hasConceptScore W4313405586C159985019 @default.
• W4313405586 hasConceptScore W4313405586C178790620 @default.
• W4313405586 hasConceptScore W4313405586C185592680 @default.
• W4313405586 hasConceptScore W4313405586C192562407 @default.

• next