Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313405730> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313405730 endingPage "55.13" @default.
- W4313405730 startingPage "55.13" @default.
- W4313405730 abstract "Abstract The X chromosome linked RNA helicase DDX3X plays numerous roles in regulation of cellular RNA metabolism and immune responses. Loss of function mutations in this helicase are linked to neurological disease and malignancies, including NK/T-cell lymphoma. To investigate how DDX3X contributes to development of NK cells, we generated mice with a conditional deletion Ddx3x in Ncr1-expressing cells. Female mice with homozygous deletion of NK cells exhibit a complete loss of NK cells. By comparison, the frequency of NK cells was significantly reduced in hemizygous male mice. The reduction in NK cells is associated with increased apoptosis in this lineage early during differentiation in the bone marrow. Our ongoing work is focused on elucidation of the mechanisms by which DDX3X regulates NK cell survival, differentiation, and malignant transformation, as well as on the capacity of DDX3Y to compensate for loss of DDX3X in hemizygous male mice. Our data identify a novel role for DDX3 RNA helicases in the development and survival of NK cells in mice." @default.
- W4313405730 created "2023-01-06" @default.
- W4313405730 creator A5006537791 @default.
- W4313405730 creator A5017780269 @default.
- W4313405730 creator A5044730133 @default.
- W4313405730 creator A5045242630 @default.
- W4313405730 creator A5050908952 @default.
- W4313405730 creator A5072232666 @default.
- W4313405730 creator A5080269187 @default.
- W4313405730 date "2022-05-01" @default.
- W4313405730 modified "2023-10-16" @default.
- W4313405730 title "A role for a DEAD box RNA helicase in natural killer cells" @default.
- W4313405730 doi "https://doi.org/10.4049/jimmunol.208.supp.55.13" @default.
- W4313405730 hasPublicationYear "2022" @default.
- W4313405730 type Work @default.
- W4313405730 citedByCount "0" @default.
- W4313405730 crossrefType "journal-article" @default.
- W4313405730 hasAuthorship W4313405730A5006537791 @default.
- W4313405730 hasAuthorship W4313405730A5017780269 @default.
- W4313405730 hasAuthorship W4313405730A5044730133 @default.
- W4313405730 hasAuthorship W4313405730A5045242630 @default.
- W4313405730 hasAuthorship W4313405730A5050908952 @default.
- W4313405730 hasAuthorship W4313405730A5072232666 @default.
- W4313405730 hasAuthorship W4313405730A5080269187 @default.
- W4313405730 hasConcept C104317684 @default.
- W4313405730 hasConcept C1491633281 @default.
- W4313405730 hasConcept C161223559 @default.
- W4313405730 hasConcept C203014093 @default.
- W4313405730 hasConcept C502942594 @default.
- W4313405730 hasConcept C54355233 @default.
- W4313405730 hasConcept C67705224 @default.
- W4313405730 hasConcept C68592252 @default.
- W4313405730 hasConcept C86803240 @default.
- W4313405730 hasConcept C8891405 @default.
- W4313405730 hasConcept C95444343 @default.
- W4313405730 hasConceptScore W4313405730C104317684 @default.
- W4313405730 hasConceptScore W4313405730C1491633281 @default.
- W4313405730 hasConceptScore W4313405730C161223559 @default.
- W4313405730 hasConceptScore W4313405730C203014093 @default.
- W4313405730 hasConceptScore W4313405730C502942594 @default.
- W4313405730 hasConceptScore W4313405730C54355233 @default.
- W4313405730 hasConceptScore W4313405730C67705224 @default.
- W4313405730 hasConceptScore W4313405730C68592252 @default.
- W4313405730 hasConceptScore W4313405730C86803240 @default.
- W4313405730 hasConceptScore W4313405730C8891405 @default.
- W4313405730 hasConceptScore W4313405730C95444343 @default.
- W4313405730 hasIssue "1_Supplement" @default.
- W4313405730 hasLocation W43134057301 @default.
- W4313405730 hasOpenAccess W4313405730 @default.
- W4313405730 hasPrimaryLocation W43134057301 @default.
- W4313405730 hasRelatedWork W10114010 @default.
- W4313405730 hasRelatedWork W1560452225 @default.
- W4313405730 hasRelatedWork W1864969543 @default.
- W4313405730 hasRelatedWork W2007245155 @default.
- W4313405730 hasRelatedWork W2035775466 @default.
- W4313405730 hasRelatedWork W2057990302 @default.
- W4313405730 hasRelatedWork W2058819725 @default.
- W4313405730 hasRelatedWork W2239325055 @default.
- W4313405730 hasRelatedWork W2762814002 @default.
- W4313405730 hasRelatedWork W4210760627 @default.
- W4313405730 hasVolume "208" @default.
- W4313405730 isParatext "false" @default.
- W4313405730 isRetracted "false" @default.
- W4313405730 workType "article" @default.