Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313405880> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4313405880 endingPage "161.19" @default.
- W4313405880 startingPage "161.19" @default.
- W4313405880 abstract "Abstract T cells from young children may be limited in capacity to mount pro-inflammatory responses to intracellular pathogens, thus contributing to vulnerability to TB disease. We compared CD4+ and CD8+ T cell cytokine production in response to mycobacterial antigens and mitogen SEB, between Ugandan children <5 yr (PedTB) and adults (ATB) with culture-confirmed pulmonary TB. HIV-uninfected children (n=12) and adults (n=41) had blood drawn for PBMC isolation prior to TB treatment. CD4+ and CD8+ T cell production of IFNγ, IL2, and TNFα in response to ESAT6/CFP10 (EC), ESXJ, PE12/13, PE3, PPE15, and PPE51 peptide pools, and SEB, were assessed by intracellular flow cytometry. Proportions and frequencies of CD4+ and CD8+ T cells producing cytokines were compared using Fisher’s Exact and Kruskal-Wallis tests, respectively, with adjusted p-values <0.05 significant. PedTB and ATB had equivalent CD4+ and CD8+ T cell production of IFNγ, IL2, and TNFα, including polyfunctional responses, to EC. T cell cytokine responses to ESXJ and PPE51 were equivalent; significant differences were noted in CD4+ T cell responses to PE3 and PPE15, and CD8+ T cell responses to PE12/13. Frequencies of CD4+ T cells producing IFNγ or IL2 in response to SEB were lower (p<0.0001) in PedTB versus ATB. Young children with PedTB exhibited adult-like capacity to generate Th-1 cytokines in response to EC, ESXJ, and PPE 51. Pediatric responses to PE3, PPE15, and PE12/13 were impaired, suggesting that the breath of antigen recognition differs between infants and adults with TB. Differential T cell recognition of mycobacterial antigens between adults and children should be considered in development of novel T cell based diagnostics and vaccines targeting pediatric TB. Supporting from grants by NIH: AI157807; HHSN272200900053C" @default.
- W4313405880 created "2023-01-06" @default.
- W4313405880 creator A5015256545 @default.
- W4313405880 creator A5017538208 @default.
- W4313405880 creator A5018711294 @default.
- W4313405880 creator A5024642684 @default.
- W4313405880 creator A5029065307 @default.
- W4313405880 creator A5032119661 @default.
- W4313405880 creator A5037204485 @default.
- W4313405880 creator A5046763808 @default.
- W4313405880 creator A5048853375 @default.
- W4313405880 creator A5059639360 @default.
- W4313405880 date "2022-05-01" @default.
- W4313405880 modified "2023-09-23" @default.
- W4313405880 title "Differential CD4+ and CD8+ T cell recognition of mycobacteria antigens in pediatric versus adult TB" @default.
- W4313405880 doi "https://doi.org/10.4049/jimmunol.208.supp.161.19" @default.
- W4313405880 hasPublicationYear "2022" @default.
- W4313405880 type Work @default.
- W4313405880 citedByCount "0" @default.
- W4313405880 crossrefType "journal-article" @default.
- W4313405880 hasAuthorship W4313405880A5015256545 @default.
- W4313405880 hasAuthorship W4313405880A5017538208 @default.
- W4313405880 hasAuthorship W4313405880A5018711294 @default.
- W4313405880 hasAuthorship W4313405880A5024642684 @default.
- W4313405880 hasAuthorship W4313405880A5029065307 @default.
- W4313405880 hasAuthorship W4313405880A5032119661 @default.
- W4313405880 hasAuthorship W4313405880A5037204485 @default.
- W4313405880 hasAuthorship W4313405880A5046763808 @default.
- W4313405880 hasAuthorship W4313405880A5048853375 @default.
- W4313405880 hasAuthorship W4313405880A5059639360 @default.
- W4313405880 hasConcept C137061746 @default.
- W4313405880 hasConcept C147483822 @default.
- W4313405880 hasConcept C154317977 @default.
- W4313405880 hasConcept C167672396 @default.
- W4313405880 hasConcept C202751555 @default.
- W4313405880 hasConcept C203014093 @default.
- W4313405880 hasConcept C2776090121 @default.
- W4313405880 hasConcept C2778690821 @default.
- W4313405880 hasConcept C2780841837 @default.
- W4313405880 hasConcept C2992881475 @default.
- W4313405880 hasConcept C553184892 @default.
- W4313405880 hasConcept C55493867 @default.
- W4313405880 hasConcept C71924100 @default.
- W4313405880 hasConcept C79879829 @default.
- W4313405880 hasConcept C86803240 @default.
- W4313405880 hasConcept C8891405 @default.
- W4313405880 hasConceptScore W4313405880C137061746 @default.
- W4313405880 hasConceptScore W4313405880C147483822 @default.
- W4313405880 hasConceptScore W4313405880C154317977 @default.
- W4313405880 hasConceptScore W4313405880C167672396 @default.
- W4313405880 hasConceptScore W4313405880C202751555 @default.
- W4313405880 hasConceptScore W4313405880C203014093 @default.
- W4313405880 hasConceptScore W4313405880C2776090121 @default.
- W4313405880 hasConceptScore W4313405880C2778690821 @default.
- W4313405880 hasConceptScore W4313405880C2780841837 @default.
- W4313405880 hasConceptScore W4313405880C2992881475 @default.
- W4313405880 hasConceptScore W4313405880C553184892 @default.
- W4313405880 hasConceptScore W4313405880C55493867 @default.
- W4313405880 hasConceptScore W4313405880C71924100 @default.
- W4313405880 hasConceptScore W4313405880C79879829 @default.
- W4313405880 hasConceptScore W4313405880C86803240 @default.
- W4313405880 hasConceptScore W4313405880C8891405 @default.
- W4313405880 hasIssue "1_Supplement" @default.
- W4313405880 hasLocation W43134058801 @default.
- W4313405880 hasOpenAccess W4313405880 @default.
- W4313405880 hasPrimaryLocation W43134058801 @default.
- W4313405880 hasRelatedWork W1934588590 @default.
- W4313405880 hasRelatedWork W2012012488 @default.
- W4313405880 hasRelatedWork W2035635493 @default.
- W4313405880 hasRelatedWork W2082514292 @default.
- W4313405880 hasRelatedWork W2087976276 @default.
- W4313405880 hasRelatedWork W2113148377 @default.
- W4313405880 hasRelatedWork W2139188664 @default.
- W4313405880 hasRelatedWork W2153702996 @default.
- W4313405880 hasRelatedWork W2159389701 @default.
- W4313405880 hasRelatedWork W2620342065 @default.
- W4313405880 hasVolume "208" @default.
- W4313405880 isParatext "false" @default.
- W4313405880 isRetracted "false" @default.
- W4313405880 workType "article" @default.