Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313405932> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4313405932 endingPage "113.23" @default.
- W4313405932 startingPage "113.23" @default.
- W4313405932 abstract "Abstract Intestinal Tim4+ CD4+ macrophages are a distinctive macrophage subset that express Tim4, a receptor for phosphatidylserine on dying apoptotic cells, Unlike other macrophage subsets, they do not depend on blood monocytes for their turnover, instead self-maintained in the small intestine. The signal(s) responsible for the self-maintenance and function of Tim4+ CD4+ macrophages is not known. We have discovered that maintenance of the gut resident Tim4+ CD4+ macrophage population depends on dietary vitamin A and its derivative retinoic acid (RA). Retinoic acid receptors, which direct RA-dependent transcription, were required for maintenance of Tim4+ CD4+ macrophages. Chemical blockade of retinoic acid receptor (RAR) signaling and macrophage-specific genetic inactivation of RARs in mice further revealed that macrophage-intrinsic RARα signaling was required for Timd4 expression and maintenance of Tim4+ CD4+ macrophages. Macrophage RARα signaling was furthermore essential for phagocytosis by Tim4+ CD4+ macrophages. Ongoing studies are examining the role of Tim4+ CD4+ macrophages and vitamin A in the clearance of apoptotic intestinal epithelial cells. Our findings reveal that vitamin A provides an essential dietary signal for the maintenance and function of a gut resident macrophage subset. Supported by Welch foundation grant I-1874" @default.
- W4313405932 created "2023-01-06" @default.
- W4313405932 creator A5021305446 @default.
- W4313405932 creator A5021539149 @default.
- W4313405932 creator A5049357046 @default.
- W4313405932 creator A5066058761 @default.
- W4313405932 creator A5081784180 @default.
- W4313405932 date "2022-05-01" @default.
- W4313405932 modified "2023-09-27" @default.
- W4313405932 title "Vitamin A regulates phagocytosis by resident macrophages of the small intestine" @default.
- W4313405932 doi "https://doi.org/10.4049/jimmunol.208.supp.113.23" @default.
- W4313405932 hasPublicationYear "2022" @default.
- W4313405932 type Work @default.
- W4313405932 citedByCount "0" @default.
- W4313405932 crossrefType "journal-article" @default.
- W4313405932 hasAuthorship W4313405932A5021305446 @default.
- W4313405932 hasAuthorship W4313405932A5021539149 @default.
- W4313405932 hasAuthorship W4313405932A5049357046 @default.
- W4313405932 hasAuthorship W4313405932A5066058761 @default.
- W4313405932 hasAuthorship W4313405932A5081784180 @default.
- W4313405932 hasConcept C120197328 @default.
- W4313405932 hasConcept C160448771 @default.
- W4313405932 hasConcept C202751555 @default.
- W4313405932 hasConcept C2779244956 @default.
- W4313405932 hasConcept C2781121885 @default.
- W4313405932 hasConcept C54355233 @default.
- W4313405932 hasConcept C55493867 @default.
- W4313405932 hasConcept C81885089 @default.
- W4313405932 hasConcept C86803240 @default.
- W4313405932 hasConcept C95444343 @default.
- W4313405932 hasConceptScore W4313405932C120197328 @default.
- W4313405932 hasConceptScore W4313405932C160448771 @default.
- W4313405932 hasConceptScore W4313405932C202751555 @default.
- W4313405932 hasConceptScore W4313405932C2779244956 @default.
- W4313405932 hasConceptScore W4313405932C2781121885 @default.
- W4313405932 hasConceptScore W4313405932C54355233 @default.
- W4313405932 hasConceptScore W4313405932C55493867 @default.
- W4313405932 hasConceptScore W4313405932C81885089 @default.
- W4313405932 hasConceptScore W4313405932C86803240 @default.
- W4313405932 hasConceptScore W4313405932C95444343 @default.
- W4313405932 hasIssue "1_Supplement" @default.
- W4313405932 hasLocation W43134059321 @default.
- W4313405932 hasOpenAccess W4313405932 @default.
- W4313405932 hasPrimaryLocation W43134059321 @default.
- W4313405932 hasRelatedWork W103532831 @default.
- W4313405932 hasRelatedWork W1941191760 @default.
- W4313405932 hasRelatedWork W1968736434 @default.
- W4313405932 hasRelatedWork W1969752809 @default.
- W4313405932 hasRelatedWork W1988602103 @default.
- W4313405932 hasRelatedWork W2030131753 @default.
- W4313405932 hasRelatedWork W2044210292 @default.
- W4313405932 hasRelatedWork W2101126979 @default.
- W4313405932 hasRelatedWork W4289598273 @default.
- W4313405932 hasRelatedWork W4313405932 @default.
- W4313405932 hasVolume "208" @default.
- W4313405932 isParatext "false" @default.
- W4313405932 isRetracted "false" @default.
- W4313405932 workType "article" @default.