Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313405946> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W4313405946 endingPage "112.28" @default.
- W4313405946 startingPage "112.28" @default.
- W4313405946 abstract "Abstract Systemic lupus erythematosus (SLE) is the most common form of lupus; however, only one new drug was approved for SLE in the last 60 years. Inhibition of glycolysis via 2-deoxyglucose (2DG), a competitive inhibitor of glucose-6-phosphate, has recently shown efficacy in attenuating tumor growth and reducing autoimmune pathology; however, the mechanism of this efficacy is somewhat unclear. To elucidate how 2DG longitudinally modulates pathways within the context of systemic lupus erythematosus (SLE), BXSB.Yaa IL15−/−,CD8−/− mice, an SLE model, were treated orally with 2DG for 96-hours or 4-weeks, after which the transcriptional profiles of 9 tissues (heart, hippocampus, hypothalamus, kidney, liver, prefrontal cortex, skeletal muscle, small intestine, and spleen) were analyzed using unsupervised clustering and weighted gene correlation network analysis. Principal component analysis showed mice clustered by tissue. Tissues correlated to B cells and T follicular helper cells grouped together according to their summary gene expression for modules treatment or treatment, in a time dependent manner, and three pathway groups, transcription, immune, and glucose, emerged. However, within each tissue cluster, pathways for each module were uniquely altered by treatment or treatment, in a time dependent manner, according to ANOVA. Furthermore, while most pathways identified were grouped into either immune or metabolic, there was little overlap of specific pathways identified between tissues. These results show that 2DG has a systemic impact altering immune and metabolic pathways, but in a tissue-specific manner. Ongoing work includes identifying genes that are potentially central to pathway alterations for follow-up analysis. Supported by the AAI Intersect Fellowship" @default.
- W4313405946 created "2023-01-06" @default.
- W4313405946 creator A5009182800 @default.
- W4313405946 creator A5018199914 @default.
- W4313405946 creator A5024080952 @default.
- W4313405946 creator A5039997604 @default.
- W4313405946 creator A5044172438 @default.
- W4313405946 date "2022-05-01" @default.
- W4313405946 modified "2023-09-23" @default.
- W4313405946 title "Inhibition of Glycolysis Modifies Distinctive Metabolic and Immune Pathways Across Multiple Tissue Compartments Associated with B and T Follicular Helper Cells" @default.
- W4313405946 doi "https://doi.org/10.4049/jimmunol.208.supp.112.28" @default.
- W4313405946 hasPublicationYear "2022" @default.
- W4313405946 type Work @default.
- W4313405946 citedByCount "0" @default.
- W4313405946 crossrefType "journal-article" @default.
- W4313405946 hasAuthorship W4313405946A5009182800 @default.
- W4313405946 hasAuthorship W4313405946A5018199914 @default.
- W4313405946 hasAuthorship W4313405946A5024080952 @default.
- W4313405946 hasAuthorship W4313405946A5039997604 @default.
- W4313405946 hasAuthorship W4313405946A5044172438 @default.
- W4313405946 hasConcept C134018914 @default.
- W4313405946 hasConcept C20251656 @default.
- W4313405946 hasConcept C203014093 @default.
- W4313405946 hasConcept C2780931953 @default.
- W4313405946 hasConcept C502942594 @default.
- W4313405946 hasConcept C62231903 @default.
- W4313405946 hasConcept C86803240 @default.
- W4313405946 hasConcept C8891405 @default.
- W4313405946 hasConceptScore W4313405946C134018914 @default.
- W4313405946 hasConceptScore W4313405946C20251656 @default.
- W4313405946 hasConceptScore W4313405946C203014093 @default.
- W4313405946 hasConceptScore W4313405946C2780931953 @default.
- W4313405946 hasConceptScore W4313405946C502942594 @default.
- W4313405946 hasConceptScore W4313405946C62231903 @default.
- W4313405946 hasConceptScore W4313405946C86803240 @default.
- W4313405946 hasConceptScore W4313405946C8891405 @default.
- W4313405946 hasIssue "1_Supplement" @default.
- W4313405946 hasLocation W43134059461 @default.
- W4313405946 hasOpenAccess W4313405946 @default.
- W4313405946 hasPrimaryLocation W43134059461 @default.
- W4313405946 hasRelatedWork W140295565 @default.
- W4313405946 hasRelatedWork W1498654104 @default.
- W4313405946 hasRelatedWork W2006139140 @default.
- W4313405946 hasRelatedWork W2081358646 @default.
- W4313405946 hasRelatedWork W2165321096 @default.
- W4313405946 hasRelatedWork W2291074595 @default.
- W4313405946 hasRelatedWork W2374622757 @default.
- W4313405946 hasRelatedWork W283322767 @default.
- W4313405946 hasRelatedWork W3201639896 @default.
- W4313405946 hasRelatedWork W4385372683 @default.
- W4313405946 hasVolume "208" @default.
- W4313405946 isParatext "false" @default.
- W4313405946 isRetracted "false" @default.
- W4313405946 workType "article" @default.