Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313406543> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4313406543 endingPage "113584" @default.
- W4313406543 startingPage "113584" @default.
- W4313406543 abstract "The absolute configurations of the known but unusual spiro-flavostilbenoids found in the bark of Yucca schidigera Roezl ex Ortgies, were determined by applying time-dependent density functional theory simulation of electronic circular dichroism spectra. The absolute configurations obtained were as follows: (2S,3R) for yuccaol A, yuccaol D and yuccalide A; (2S,3S) for yuccaol B, yuccaol C and yuccaol E; (2S,3S,2'S,3'S) for gloriosaol A; (2S,3R,2'S,3'R) for gloriosaol C; (2S,3S,2'S,3'R) for gloriosaol D; (2S,3R,2'S,3'S) for gloriosaol E. These findings indicate that the compounds are all biosynthetic derivatives either of (2R)-naringenin and trans-resveratrol or of trans-3,3',5,5'-tetrahydroxy-4'-methoxystilbene. In contrast, gloriosaols are direct derivatives of yuccaols (note that substituting by stilbenoid changes the absolute configuration of C-2 naringenin carbon to 2S). A putative mechanism for their biosynthesis is proposed taking into account key aspects of regio- and stereoselectivity. Yuccaol B and gloriosaol A showed in vitro moderate inhibitory effects against acetyl-/butyrylcholinesterases (AChE/BChE) with IC50 values of 43/81 and 45/65 μM respectively. The selectivity index values calculated from the IC50 values of BChE and AChE were 1.9 and 1.4. Molecular docking simulations showed their interaction with the peripheral anionic site of human AChE and the catalytic site of the human BChE." @default.
- W4313406543 created "2023-01-06" @default.
- W4313406543 creator A5009204504 @default.
- W4313406543 creator A5039291697 @default.
- W4313406543 creator A5040239161 @default.
- W4313406543 creator A5052108258 @default.
- W4313406543 creator A5062125795 @default.
- W4313406543 creator A5077276290 @default.
- W4313406543 creator A5082663764 @default.
- W4313406543 creator A5084809907 @default.
- W4313406543 date "2023-03-01" @default.
- W4313406543 modified "2023-09-27" @default.
- W4313406543 title "Absolute configuration of spiro-flavostilbenoids from Yucca schidigera Roezl ex Ortgies: First indication of (2R)-naringenin as the key building block" @default.
- W4313406543 cites W1546531859 @default.
- W4313406543 cites W1967013292 @default.
- W4313406543 cites W1968107187 @default.
- W4313406543 cites W1968800504 @default.
- W4313406543 cites W1973841828 @default.
- W4313406543 cites W1980704866 @default.
- W4313406543 cites W1988038144 @default.
- W4313406543 cites W1999441183 @default.
- W4313406543 cites W2009778713 @default.
- W4313406543 cites W2021846814 @default.
- W4313406543 cites W2024553502 @default.
- W4313406543 cites W2037461711 @default.
- W4313406543 cites W2043658172 @default.
- W4313406543 cites W2057267888 @default.
- W4313406543 cites W2058000080 @default.
- W4313406543 cites W2062852634 @default.
- W4313406543 cites W2064450587 @default.
- W4313406543 cites W2072781790 @default.
- W4313406543 cites W2075304800 @default.
- W4313406543 cites W2076166567 @default.
- W4313406543 cites W2101363734 @default.
- W4313406543 cites W2127098620 @default.
- W4313406543 cites W2129494489 @default.
- W4313406543 cites W2136138495 @default.
- W4313406543 cites W2337020540 @default.
- W4313406543 cites W2577257276 @default.
- W4313406543 cites W2789265239 @default.
- W4313406543 cites W2952079882 @default.
- W4313406543 cites W2952534443 @default.
- W4313406543 cites W2983405037 @default.
- W4313406543 cites W3033568651 @default.
- W4313406543 cites W3045353567 @default.
- W4313406543 cites W3088274117 @default.
- W4313406543 cites W4282829634 @default.
- W4313406543 doi "https://doi.org/10.1016/j.phytochem.2022.113584" @default.
- W4313406543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36603655" @default.
- W4313406543 hasPublicationYear "2023" @default.
- W4313406543 type Work @default.
- W4313406543 citedByCount "1" @default.
- W4313406543 countsByYear W43134065432023 @default.
- W4313406543 crossrefType "journal-article" @default.
- W4313406543 hasAuthorship W4313406543A5009204504 @default.
- W4313406543 hasAuthorship W4313406543A5039291697 @default.
- W4313406543 hasAuthorship W4313406543A5040239161 @default.
- W4313406543 hasAuthorship W4313406543A5052108258 @default.
- W4313406543 hasAuthorship W4313406543A5062125795 @default.
- W4313406543 hasAuthorship W4313406543A5077276290 @default.
- W4313406543 hasAuthorship W4313406543A5082663764 @default.
- W4313406543 hasAuthorship W4313406543A5084809907 @default.
- W4313406543 hasConcept C133571119 @default.
- W4313406543 hasConcept C185592680 @default.
- W4313406543 hasConcept C25170562 @default.
- W4313406543 hasConcept C2776848411 @default.
- W4313406543 hasConcept C2778004101 @default.
- W4313406543 hasConcept C2779054382 @default.
- W4313406543 hasConcept C55493867 @default.
- W4313406543 hasConcept C71240020 @default.
- W4313406543 hasConceptScore W4313406543C133571119 @default.
- W4313406543 hasConceptScore W4313406543C185592680 @default.
- W4313406543 hasConceptScore W4313406543C25170562 @default.
- W4313406543 hasConceptScore W4313406543C2776848411 @default.
- W4313406543 hasConceptScore W4313406543C2778004101 @default.
- W4313406543 hasConceptScore W4313406543C2779054382 @default.
- W4313406543 hasConceptScore W4313406543C55493867 @default.
- W4313406543 hasConceptScore W4313406543C71240020 @default.
- W4313406543 hasLocation W43134065431 @default.
- W4313406543 hasLocation W43134065432 @default.
- W4313406543 hasLocation W43134065433 @default.
- W4313406543 hasOpenAccess W4313406543 @default.
- W4313406543 hasPrimaryLocation W43134065431 @default.
- W4313406543 hasRelatedWork W1974480574 @default.
- W4313406543 hasRelatedWork W1992115507 @default.
- W4313406543 hasRelatedWork W2048525790 @default.
- W4313406543 hasRelatedWork W2079453961 @default.
- W4313406543 hasRelatedWork W2178968939 @default.
- W4313406543 hasRelatedWork W2219616796 @default.
- W4313406543 hasRelatedWork W2314102258 @default.
- W4313406543 hasRelatedWork W2610597779 @default.
- W4313406543 hasRelatedWork W2895478872 @default.
- W4313406543 hasRelatedWork W3213506518 @default.
- W4313406543 hasVolume "207" @default.
- W4313406543 isParatext "false" @default.
- W4313406543 isRetracted "false" @default.
- W4313406543 workType "article" @default.