Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313406947> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4313406947 endingPage "110.01" @default.
- W4313406947 startingPage "110.01" @default.
- W4313406947 abstract "Abstract Differences in susceptibility to and severity of infectious diseases between the sexes are well established. Females often generate a beneficially stronger immune response when combatting infection but show an increased risk of developing autoimmunity. While the sex-related hormone estradiol is known to affect CD4 T cell cytokine release in vitro, less is known about T cells behavior in vivo. To address this, we intravenously infected male and female mice with attenuated Salmonella Typhimurium (S. Tm). By day 15 post infection (p.i.), male mice showed significantly lower rates of survival. Males also generated a higher number of S. Tm-specific CD4 T cells in the liver but, conversely, displayed higher bacterial burdens. To isolate the role of sex hormones, mice were gonadectomized before reaching sexual maturity and then infected. Ovariectomized mice lost significantly more weight than ovary-intact females by day 15 p.i. Like normal males, ovariectomized females demonstrated a significantly higher number of S. Tm-specific CD4 T cells but also higher liver bacterial burdens. To investigate the role of extra-lymphoid tissues such as the liver, we infected lymphotoxin-alpha (LTa) mice that genetically lack lymphoid tissues. Surprisingly, we found the stark difference in survival and CD4 T cell expansion between the sexes was lost. These differences in T cell expansion, and the commensurate effect on survival, in the presence or absence of endogenous sex hormones or lymphoid tissues indicate that females may have evolved a separate ability to regulate immune responses outside of traditional lymphoid organs. These studies will provide insights into sex-based differences seen in cellular immunity against bacterial pathogens in vivo. Supported by a grant from the Keck Foundation" @default.
- W4313406947 created "2023-01-06" @default.
- W4313406947 creator A5054333550 @default.
- W4313406947 creator A5065890669 @default.
- W4313406947 creator A5083215251 @default.
- W4313406947 creator A5091202762 @default.
- W4313406947 date "2022-05-01" @default.
- W4313406947 modified "2023-09-26" @default.
- W4313406947 title "Sexual dimorphism in the antigen-specific T cell response in <i>S.</i> Typhimurium infections within extra-lymphoid tissues" @default.
- W4313406947 doi "https://doi.org/10.4049/jimmunol.208.supp.110.01" @default.
- W4313406947 hasPublicationYear "2022" @default.
- W4313406947 type Work @default.
- W4313406947 citedByCount "0" @default.
- W4313406947 crossrefType "journal-article" @default.
- W4313406947 hasAuthorship W4313406947A5054333550 @default.
- W4313406947 hasAuthorship W4313406947A5065890669 @default.
- W4313406947 hasAuthorship W4313406947A5083215251 @default.
- W4313406947 hasAuthorship W4313406947A5091202762 @default.
- W4313406947 hasConcept C105083479 @default.
- W4313406947 hasConcept C126322002 @default.
- W4313406947 hasConcept C134018914 @default.
- W4313406947 hasConcept C147483822 @default.
- W4313406947 hasConcept C192536144 @default.
- W4313406947 hasConcept C203014093 @default.
- W4313406947 hasConcept C2776090121 @default.
- W4313406947 hasConcept C2778324911 @default.
- W4313406947 hasConcept C71315377 @default.
- W4313406947 hasConcept C71924100 @default.
- W4313406947 hasConcept C8264082 @default.
- W4313406947 hasConcept C86803240 @default.
- W4313406947 hasConcept C8891405 @default.
- W4313406947 hasConceptScore W4313406947C105083479 @default.
- W4313406947 hasConceptScore W4313406947C126322002 @default.
- W4313406947 hasConceptScore W4313406947C134018914 @default.
- W4313406947 hasConceptScore W4313406947C147483822 @default.
- W4313406947 hasConceptScore W4313406947C192536144 @default.
- W4313406947 hasConceptScore W4313406947C203014093 @default.
- W4313406947 hasConceptScore W4313406947C2776090121 @default.
- W4313406947 hasConceptScore W4313406947C2778324911 @default.
- W4313406947 hasConceptScore W4313406947C71315377 @default.
- W4313406947 hasConceptScore W4313406947C71924100 @default.
- W4313406947 hasConceptScore W4313406947C8264082 @default.
- W4313406947 hasConceptScore W4313406947C86803240 @default.
- W4313406947 hasConceptScore W4313406947C8891405 @default.
- W4313406947 hasIssue "1_Supplement" @default.
- W4313406947 hasLocation W43134069471 @default.
- W4313406947 hasOpenAccess W4313406947 @default.
- W4313406947 hasPrimaryLocation W43134069471 @default.
- W4313406947 hasRelatedWork W1978549386 @default.
- W4313406947 hasRelatedWork W1981503997 @default.
- W4313406947 hasRelatedWork W1995863458 @default.
- W4313406947 hasRelatedWork W2009754781 @default.
- W4313406947 hasRelatedWork W2030512885 @default.
- W4313406947 hasRelatedWork W2071078849 @default.
- W4313406947 hasRelatedWork W2077416684 @default.
- W4313406947 hasRelatedWork W2085671461 @default.
- W4313406947 hasRelatedWork W2993561967 @default.
- W4313406947 hasRelatedWork W4322772232 @default.
- W4313406947 hasVolume "208" @default.
- W4313406947 isParatext "false" @default.
- W4313406947 isRetracted "false" @default.
- W4313406947 workType "article" @default.