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- W4313406970 abstract "Abstract The pro-inflammatory microRNA-155 (miR-155) is highly expressed in the serum and CNS lesions of patients with multiple sclerosis (MS). The whole-body deletion of miR-155 in mice confers resistance to a mouse model of MS, EAE, by reducing the encephalogenic potential of CNS-infiltrating Th17 T cells. Here we utilize single-cell RNA sequencing and cell-specific conditional miR-155 knockouts to determine the importance of miR-155 expression in distinct cell populations. Time course single-cell sequencing revealed reductions in T cells, macrophages, and dendritic cells in whole-body miR-155 knockout mice compared with wild-type controls at day 21. Deletion of miR-155 in T cells, driven by CD4 cre, reduced disease severity similar to whole-body miR-155 knockouts. CD11c cre-driven deletion of miR-155 in dendritic cells also significantly reduced EAE disease score, with both T cell and dendritic cell-specific knockouts showing a reduction in Th17 T cell infiltration into the CNS. Although miR-155 is highly expressed in macrophages during EAE, deletion miR-155 by LysM cre in did not affect disease severity." @default.
- W4313406970 created "2023-01-06" @default.
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- W4313406970 date "2022-05-01" @default.
- W4313406970 modified "2023-10-16" @default.
- W4313406970 title "Cell-specific roles for miR-155 during neuroinflammation" @default.
- W4313406970 doi "https://doi.org/10.4049/jimmunol.208.supp.166.10" @default.
- W4313406970 hasPublicationYear "2022" @default.
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