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- W4313407935 abstract "Abstract The emergence of SARS-CoV-2 variants raises concerns about the efficacy of COVID-19 vaccines to induce an immune response capable of recognizing upcoming variants. While there are multiple studies detailing the impact of SARS-CoV-2 variants on neutralizing antibodies, there is relatively little information on the effect of variant mutations on CD4 and CD8 T cell recognition. We will present the results of our ongoing study on the effects on T cell reactivity to a comprehensive panel of variants circulating globally (B.1.617.2 [delta], P.1 [gamma], B.1.617.1 [kappa], C.37 [lambda], R.1, B.1.1.7 [alpha], B.1.351 [beta], B.1.1.519, B.1.525 [eta], B.1.526 [iota], B.1.427/9 [epsilon], B.1.526.1 and B.1.621 [mu] comparing it with the most recent B.1.1.529 [omicron] variant. The results will span from bioinformatics analyses addressing the effect of SARS-CoV-2 mutations of known epitopes in the Immune Epitope Database (IEDB, https://www.iedb.org/) to the experimental evaluation of the T cell responses specific to each SARS-CoV-2 Spike variant in individuals immunized with several vaccine platforms and at multiple timepoints after vaccination. Parallel experiments will also determine the epitope repertoire in specific donors and dissect the impact of SARS-CoV-2 variant associated mutations on the recognition of each CD4 and CD8 T cell epitope. Finally, the capability of T cell cross-recognition will be compared with breakthrough infection and with or without booster vaccination. This project has been funded in whole or in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. 75N93021C00016 to A.S. and Contract No. 75N9301900065 to A.S, D.W." @default.
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- W4313407935 date "2022-05-01" @default.
- W4313407935 modified "2023-10-16" @default.
- W4313407935 title "SARS-CoV-2 vaccination induces T cell memory responses able to cross-recognize ongoing SARS-CoV-2 variants including omicron." @default.
- W4313407935 doi "https://doi.org/10.4049/jimmunol.208.supp.125.03" @default.
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