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- W4313407943 abstract "Abstract Dendritic cells (DCs) are an important link between the innate and adaptive immune systems, specifically by serving as key regulators of T cell-dependent (TD) immune responses. In DCs, several processes critical for initiating TD immune responses, such as migration, provision of costimulatory signals, and antigen uptake and presentation, utilize the mitogen-activated protein kinase (MAPK) signaling pathway. The dysregulation of these processes can result in the aberrant activation of autoreactive CD4+ T cells, resulting in autoimmune disease. Extracellular signal-regulated kinase 1 and 2 (ERK1/2) are key effectors of the MAPK pathway, and while ERK1 has been shown to be a critical regulator of DC migration and TLR-induced IL-10 secretion, the function of ERK2 remains unknown. Preliminary data has shown that Erk2Δ bone marrow-derived DCs (BMDCs), as well as Erk2Δ splenic DCs, exhibit altered expression of surface markers associated with T cell costimulation, antigen presentation, and migration compared with DCs from littermate control. Taken together, this suggests that ERK2 plays a unique role in the regulation of several DC functions, potentially opening a new approach to treating CD4+ T cell-mediated autoimmune diseases. Supported by grant R21AI44731 from the NIH/NIAID (TGF)" @default.
- W4313407943 created "2023-01-06" @default.
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- W4313407943 date "2022-05-01" @default.
- W4313407943 modified "2023-09-26" @default.
- W4313407943 title "The role of ERK2 in dendritic cell function" @default.
- W4313407943 doi "https://doi.org/10.4049/jimmunol.208.supp.164.11" @default.
- W4313407943 hasPublicationYear "2022" @default.
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