Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313408020> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4313408020 endingPage "162.06" @default.
- W4313408020 startingPage "162.06" @default.
- W4313408020 abstract "Abstract Francisella tularensis is a gram-negative intracellular coccobacillus that is the causative agent of tularemia. Local, acute inflammation is beneficial since it can clear bacterial infections, remove cellular damage and promote the healing of tissue. However, F. tularensis is capable of bypassing the immune system and causing an over-activation of inflammation, known as a “cytokine storm”. This cytokine storm increases host cell damage, nutrient availability and serves an immune distraction allowing the bacterium to replicate. Other infections that cause cytokine storms include Ebola, pandemic influenza, hantavirus, and HIV, all BSL3 pathogens. The routes of transmission for F. tularensis are many and intertwined. Infection could be the result of inhaling air droplets containing infectious bacteria, coming into direct contact with an infected animal or being bitten by an infected arthropod such as a tick, flea or mosquito. Eating and drinking contaminated meat and water can also lead to infection and different disease manifestations occur depending on the route of transmission. While extensive research has documented infection of the spleen, liver and lung, there hasn’t been any reports of F. tularensis productively infecting the brain, until now. This work focuses on characterizing the effects of F. tularensis infection of the brain. We hypothesize that damage caused by F. tularensis neural infection will have a negative effect on behavior. This work aims to identify these negative effects based on the anatomical location of the bacteria foci, regions containing numerous bacteria. With the use of brain mapping and behavioral assays, we seek to determine the impact of F. tularensis infection on behavior and cognition." @default.
- W4313408020 created "2023-01-06" @default.
- W4313408020 creator A5023450714 @default.
- W4313408020 creator A5027917351 @default.
- W4313408020 creator A5039891697 @default.
- W4313408020 creator A5086256729 @default.
- W4313408020 date "2022-05-01" @default.
- W4313408020 modified "2023-10-16" @default.
- W4313408020 title "Neural Dysfunction Following <i>Francisella tularensis</i> Infection" @default.
- W4313408020 doi "https://doi.org/10.4049/jimmunol.208.supp.162.06" @default.
- W4313408020 hasPublicationYear "2022" @default.
- W4313408020 type Work @default.
- W4313408020 citedByCount "0" @default.
- W4313408020 crossrefType "journal-article" @default.
- W4313408020 hasAuthorship W4313408020A5023450714 @default.
- W4313408020 hasAuthorship W4313408020A5027917351 @default.
- W4313408020 hasAuthorship W4313408020A5039891697 @default.
- W4313408020 hasAuthorship W4313408020A5086256729 @default.
- W4313408020 hasConcept C104317684 @default.
- W4313408020 hasConcept C119599485 @default.
- W4313408020 hasConcept C127413603 @default.
- W4313408020 hasConcept C134040284 @default.
- W4313408020 hasConcept C142724271 @default.
- W4313408020 hasConcept C159047783 @default.
- W4313408020 hasConcept C203014093 @default.
- W4313408020 hasConcept C2522874641 @default.
- W4313408020 hasConcept C2775983634 @default.
- W4313408020 hasConcept C2779134260 @default.
- W4313408020 hasConcept C2779559532 @default.
- W4313408020 hasConcept C2780467176 @default.
- W4313408020 hasConcept C2780796267 @default.
- W4313408020 hasConcept C3008058167 @default.
- W4313408020 hasConcept C524204448 @default.
- W4313408020 hasConcept C55493867 @default.
- W4313408020 hasConcept C60987743 @default.
- W4313408020 hasConcept C71924100 @default.
- W4313408020 hasConcept C761482 @default.
- W4313408020 hasConcept C86803240 @default.
- W4313408020 hasConcept C8891405 @default.
- W4313408020 hasConcept C89423630 @default.
- W4313408020 hasConceptScore W4313408020C104317684 @default.
- W4313408020 hasConceptScore W4313408020C119599485 @default.
- W4313408020 hasConceptScore W4313408020C127413603 @default.
- W4313408020 hasConceptScore W4313408020C134040284 @default.
- W4313408020 hasConceptScore W4313408020C142724271 @default.
- W4313408020 hasConceptScore W4313408020C159047783 @default.
- W4313408020 hasConceptScore W4313408020C203014093 @default.
- W4313408020 hasConceptScore W4313408020C2522874641 @default.
- W4313408020 hasConceptScore W4313408020C2775983634 @default.
- W4313408020 hasConceptScore W4313408020C2779134260 @default.
- W4313408020 hasConceptScore W4313408020C2779559532 @default.
- W4313408020 hasConceptScore W4313408020C2780467176 @default.
- W4313408020 hasConceptScore W4313408020C2780796267 @default.
- W4313408020 hasConceptScore W4313408020C3008058167 @default.
- W4313408020 hasConceptScore W4313408020C524204448 @default.
- W4313408020 hasConceptScore W4313408020C55493867 @default.
- W4313408020 hasConceptScore W4313408020C60987743 @default.
- W4313408020 hasConceptScore W4313408020C71924100 @default.
- W4313408020 hasConceptScore W4313408020C761482 @default.
- W4313408020 hasConceptScore W4313408020C86803240 @default.
- W4313408020 hasConceptScore W4313408020C8891405 @default.
- W4313408020 hasConceptScore W4313408020C89423630 @default.
- W4313408020 hasIssue "1_Supplement" @default.
- W4313408020 hasLocation W43134080201 @default.
- W4313408020 hasOpenAccess W4313408020 @default.
- W4313408020 hasPrimaryLocation W43134080201 @default.
- W4313408020 hasRelatedWork W2046161765 @default.
- W4313408020 hasRelatedWork W2081700001 @default.
- W4313408020 hasRelatedWork W2117041996 @default.
- W4313408020 hasRelatedWork W2167532717 @default.
- W4313408020 hasRelatedWork W2593698237 @default.
- W4313408020 hasRelatedWork W2912114571 @default.
- W4313408020 hasRelatedWork W2981471307 @default.
- W4313408020 hasRelatedWork W4313368560 @default.
- W4313408020 hasRelatedWork W4313408020 @default.
- W4313408020 hasRelatedWork W597594574 @default.
- W4313408020 hasVolume "208" @default.
- W4313408020 isParatext "false" @default.
- W4313408020 isRetracted "false" @default.
- W4313408020 workType "article" @default.