Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313408043> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4313408043 endingPage "182.21" @default.
- W4313408043 startingPage "182.21" @default.
- W4313408043 abstract "Abstract Tissue-resident memory CD8+ T cells (TRM) are strategically located in peripheral tissues, especially at mucosal surfaces, where they can provide protection against invading pathogenic microbes. In the lungs, TRM play a critical role in limiting disease and transmission of respiratory viruses; however, the heterogeneity present in TRM populations in the human lung remains largely unexplored. Here we show that human lungs harbor transcriptionally, epigenetically, and phenotypically distinct populations of memory CD8+ T cells expressing the tissue residency-associated markers CD69 and CD103. High-dimensional flow cytometry and single-cell RNA sequencing of memory CD8+ T cells isolated from human lungs shows that heterogeneity exists both between and within CD69+ CD103− and CD69+ CD103+ subsets, with transcriptional diversity among the CD69+ CD103− subset being most prominent. Single-cell ATACseq demonstrates that similar levels of epigenetic diversity exist between and within these different TRM subsets. However, flow cytometry and single-cell RNAseq of influenza- and SARS-CoV-2-specific lung TRM demonstrates that heterogeneity between CD69+ CD103− and CD69+ CD103+ subsets is largely eliminated when the cells are specific for a common antigen. Together, these data illuminate underappreciated and unexplored aspects of heterogeneity in TRM populations in humans. Supported by grants from NIH/NIAID (75N93019R00028) and NIH/NHLBI (R35 HL150803)" @default.
- W4313408043 created "2023-01-06" @default.
- W4313408043 creator A5001407361 @default.
- W4313408043 creator A5012065860 @default.
- W4313408043 creator A5012520517 @default.
- W4313408043 creator A5013509816 @default.
- W4313408043 creator A5015442970 @default.
- W4313408043 creator A5016717845 @default.
- W4313408043 creator A5059055832 @default.
- W4313408043 creator A5064386488 @default.
- W4313408043 creator A5081548133 @default.
- W4313408043 date "2022-05-01" @default.
- W4313408043 modified "2023-09-27" @default.
- W4313408043 title "Human lung tissue-resident memory CD8+ T cells are transcriptionally, epigenetically, and phenotypically diverse" @default.
- W4313408043 doi "https://doi.org/10.4049/jimmunol.208.supp.182.21" @default.
- W4313408043 hasPublicationYear "2022" @default.
- W4313408043 type Work @default.
- W4313408043 citedByCount "0" @default.
- W4313408043 crossrefType "journal-article" @default.
- W4313408043 hasAuthorship W4313408043A5001407361 @default.
- W4313408043 hasAuthorship W4313408043A5012065860 @default.
- W4313408043 hasAuthorship W4313408043A5012520517 @default.
- W4313408043 hasAuthorship W4313408043A5013509816 @default.
- W4313408043 hasAuthorship W4313408043A5015442970 @default.
- W4313408043 hasAuthorship W4313408043A5016717845 @default.
- W4313408043 hasAuthorship W4313408043A5059055832 @default.
- W4313408043 hasAuthorship W4313408043A5064386488 @default.
- W4313408043 hasAuthorship W4313408043A5081548133 @default.
- W4313408043 hasConcept C104317684 @default.
- W4313408043 hasConcept C127716648 @default.
- W4313408043 hasConcept C147483822 @default.
- W4313408043 hasConcept C167672396 @default.
- W4313408043 hasConcept C176324957 @default.
- W4313408043 hasConcept C203014093 @default.
- W4313408043 hasConcept C2776090121 @default.
- W4313408043 hasConcept C41091548 @default.
- W4313408043 hasConcept C54355233 @default.
- W4313408043 hasConcept C553184892 @default.
- W4313408043 hasConcept C79484868 @default.
- W4313408043 hasConcept C86803240 @default.
- W4313408043 hasConcept C8891405 @default.
- W4313408043 hasConcept C95444343 @default.
- W4313408043 hasConceptScore W4313408043C104317684 @default.
- W4313408043 hasConceptScore W4313408043C127716648 @default.
- W4313408043 hasConceptScore W4313408043C147483822 @default.
- W4313408043 hasConceptScore W4313408043C167672396 @default.
- W4313408043 hasConceptScore W4313408043C176324957 @default.
- W4313408043 hasConceptScore W4313408043C203014093 @default.
- W4313408043 hasConceptScore W4313408043C2776090121 @default.
- W4313408043 hasConceptScore W4313408043C41091548 @default.
- W4313408043 hasConceptScore W4313408043C54355233 @default.
- W4313408043 hasConceptScore W4313408043C553184892 @default.
- W4313408043 hasConceptScore W4313408043C79484868 @default.
- W4313408043 hasConceptScore W4313408043C86803240 @default.
- W4313408043 hasConceptScore W4313408043C8891405 @default.
- W4313408043 hasConceptScore W4313408043C95444343 @default.
- W4313408043 hasIssue "1_Supplement" @default.
- W4313408043 hasLocation W43134080431 @default.
- W4313408043 hasOpenAccess W4313408043 @default.
- W4313408043 hasPrimaryLocation W43134080431 @default.
- W4313408043 hasRelatedWork W1536852484 @default.
- W4313408043 hasRelatedWork W2020684972 @default.
- W4313408043 hasRelatedWork W2098223659 @default.
- W4313408043 hasRelatedWork W2103095153 @default.
- W4313408043 hasRelatedWork W2355095363 @default.
- W4313408043 hasRelatedWork W2362013622 @default.
- W4313408043 hasRelatedWork W2363096198 @default.
- W4313408043 hasRelatedWork W2382920816 @default.
- W4313408043 hasRelatedWork W2410750281 @default.
- W4313408043 hasRelatedWork W2417496657 @default.
- W4313408043 hasVolume "208" @default.
- W4313408043 isParatext "false" @default.
- W4313408043 isRetracted "false" @default.
- W4313408043 workType "article" @default.