Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313408061> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4313408061 endingPage "165.14" @default.
- W4313408061 startingPage "165.14" @default.
- W4313408061 abstract "Abstract Immune activation after tissue injury is required for removal of dead cells and debris to permit subsequent regenerative healing. Natural killer (NK) cells are innate lymphocytes that are essential for immune defense and for regulation of inflammation. NK cells limit fibrosis after cardiac muscle damage, yet the role of these cells during skeletal muscle inflammation is less clear. We hypothesize that NK cells promote acute inflammation after muscle damage but that NK cell responses must be resolved to permit regenerative healing. Following bilateral injection of cardiotoxin into tibialis anterior and gastrocnemius muscles of C57BL/6 mice, NK cell accumulation in injured muscle was detectable within 18 hours and peaked four days post-injury. Selective depletion of NK cells using a titrated dose of anti-NK1.1 antibody prior to cardiotoxin injection resulted in a substantial reduction in the overall infiltration of numerous immune cell types, including T and B cells, into the injured muscle. Thus, NK cells are an important mediator of cellular inflammation following muscle damage. Future studies will determine the mechanism by which NK cells contribute to this inflammatory response and how ablation of NK-cell mediated inflammation impacts healing of damaged muscles. Supported by National Institute of Heath (NIH) (R01-AI148080)" @default.
- W4313408061 created "2023-01-06" @default.
- W4313408061 creator A5017780269 @default.
- W4313408061 creator A5023928338 @default.
- W4313408061 creator A5030368185 @default.
- W4313408061 creator A5033535905 @default.
- W4313408061 creator A5050647763 @default.
- W4313408061 date "2022-05-01" @default.
- W4313408061 modified "2023-09-23" @default.
- W4313408061 title "Key contribution of NK cells to inflammation after muscle injury" @default.
- W4313408061 doi "https://doi.org/10.4049/jimmunol.208.supp.165.14" @default.
- W4313408061 hasPublicationYear "2022" @default.
- W4313408061 type Work @default.
- W4313408061 citedByCount "0" @default.
- W4313408061 crossrefType "journal-article" @default.
- W4313408061 hasAuthorship W4313408061A5017780269 @default.
- W4313408061 hasAuthorship W4313408061A5023928338 @default.
- W4313408061 hasAuthorship W4313408061A5030368185 @default.
- W4313408061 hasAuthorship W4313408061A5033535905 @default.
- W4313408061 hasAuthorship W4313408061A5050647763 @default.
- W4313408061 hasConcept C136449434 @default.
- W4313408061 hasConcept C142724271 @default.
- W4313408061 hasConcept C171056886 @default.
- W4313408061 hasConcept C203014093 @default.
- W4313408061 hasConcept C2776914184 @default.
- W4313408061 hasConcept C2780559512 @default.
- W4313408061 hasConcept C2909145422 @default.
- W4313408061 hasConcept C71924100 @default.
- W4313408061 hasConcept C86803240 @default.
- W4313408061 hasConcept C8891405 @default.
- W4313408061 hasConcept C95444343 @default.
- W4313408061 hasConceptScore W4313408061C136449434 @default.
- W4313408061 hasConceptScore W4313408061C142724271 @default.
- W4313408061 hasConceptScore W4313408061C171056886 @default.
- W4313408061 hasConceptScore W4313408061C203014093 @default.
- W4313408061 hasConceptScore W4313408061C2776914184 @default.
- W4313408061 hasConceptScore W4313408061C2780559512 @default.
- W4313408061 hasConceptScore W4313408061C2909145422 @default.
- W4313408061 hasConceptScore W4313408061C71924100 @default.
- W4313408061 hasConceptScore W4313408061C86803240 @default.
- W4313408061 hasConceptScore W4313408061C8891405 @default.
- W4313408061 hasConceptScore W4313408061C95444343 @default.
- W4313408061 hasIssue "1_Supplement" @default.
- W4313408061 hasLocation W43134080611 @default.
- W4313408061 hasOpenAccess W4313408061 @default.
- W4313408061 hasPrimaryLocation W43134080611 @default.
- W4313408061 hasRelatedWork W1871528077 @default.
- W4313408061 hasRelatedWork W2015469449 @default.
- W4313408061 hasRelatedWork W2097511085 @default.
- W4313408061 hasRelatedWork W2141330728 @default.
- W4313408061 hasRelatedWork W2490643024 @default.
- W4313408061 hasRelatedWork W2607165015 @default.
- W4313408061 hasRelatedWork W2765681138 @default.
- W4313408061 hasRelatedWork W3177434200 @default.
- W4313408061 hasRelatedWork W4254889678 @default.
- W4313408061 hasRelatedWork W4298878502 @default.
- W4313408061 hasVolume "208" @default.
- W4313408061 isParatext "false" @default.
- W4313408061 isRetracted "false" @default.
- W4313408061 workType "article" @default.