Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313408085> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4313408085 endingPage "178.12" @default.
- W4313408085 startingPage "178.12" @default.
- W4313408085 abstract "Abstract Chemokines and their receptors play important role in tumor progression and metastasis. In prostate cancer (PCa), some members of the CXC chemokine receptor have been shown to enhance angiogenesis, proliferation and metastasis. In this study we assess the roles of the interleukin-8 (IL-8/CXCL8) receptors CXCR1 and CXCR2 in prostate tumorigenesis, using MDA PCa 2b and LNCaP cell lines. Our results show that overexpression of CXCR2 enhanced in-vitro cell proliferation, soft agar growth and in-vivo tumor xenograft in nude mice, whereas overexpression of CXCR1 inhibited cell proliferation and tumor growth, relative to control cells. CXCR1 cells showed decrease prostate specific antigen (PSA) expression whereas CXCR2 exhibited decrease androgen receptor (AR) expression. Interestingly, tumor lysates from CXCR1 cells displayed significant increase in ERK and AKT activation as well as chemokines production relative to control and CXCR2 tumors. CXCR1 tumors also exhibited a more mesenchymal phenotype, characterized by reduced E-Cadherin but increased N-Cadherin and Vimentin expression relative to CXCR2 or control tumors. Altogether, these results indicate that CXCR1 and CXCR2 may couple to distinct pathways to modulate prostate tumorigenesis. Supported by CA156735, MD012392" @default.
- W4313408085 created "2023-01-06" @default.
- W4313408085 creator A5042227258 @default.
- W4313408085 creator A5044813063 @default.
- W4313408085 creator A5049084787 @default.
- W4313408085 creator A5060770353 @default.
- W4313408085 date "2022-05-01" @default.
- W4313408085 modified "2023-09-25" @default.
- W4313408085 title "Opposite effects of CXCR1 and CXCR2 overexpression in prostate tumorigenesis" @default.
- W4313408085 doi "https://doi.org/10.4049/jimmunol.208.supp.178.12" @default.
- W4313408085 hasPublicationYear "2022" @default.
- W4313408085 type Work @default.
- W4313408085 citedByCount "0" @default.
- W4313408085 crossrefType "journal-article" @default.
- W4313408085 hasAuthorship W4313408085A5042227258 @default.
- W4313408085 hasAuthorship W4313408085A5044813063 @default.
- W4313408085 hasAuthorship W4313408085A5049084787 @default.
- W4313408085 hasAuthorship W4313408085A5060770353 @default.
- W4313408085 hasConcept C121608353 @default.
- W4313408085 hasConcept C126322002 @default.
- W4313408085 hasConcept C12823836 @default.
- W4313408085 hasConcept C13373296 @default.
- W4313408085 hasConcept C170493617 @default.
- W4313408085 hasConcept C2776235491 @default.
- W4313408085 hasConcept C2779013556 @default.
- W4313408085 hasConcept C2779723316 @default.
- W4313408085 hasConcept C2780192828 @default.
- W4313408085 hasConcept C2780394083 @default.
- W4313408085 hasConcept C502942594 @default.
- W4313408085 hasConcept C54355233 @default.
- W4313408085 hasConcept C555283112 @default.
- W4313408085 hasConcept C62112901 @default.
- W4313408085 hasConcept C62478195 @default.
- W4313408085 hasConcept C71924100 @default.
- W4313408085 hasConcept C75217442 @default.
- W4313408085 hasConcept C84913492 @default.
- W4313408085 hasConcept C86803240 @default.
- W4313408085 hasConcept C95444343 @default.
- W4313408085 hasConceptScore W4313408085C121608353 @default.
- W4313408085 hasConceptScore W4313408085C126322002 @default.
- W4313408085 hasConceptScore W4313408085C12823836 @default.
- W4313408085 hasConceptScore W4313408085C13373296 @default.
- W4313408085 hasConceptScore W4313408085C170493617 @default.
- W4313408085 hasConceptScore W4313408085C2776235491 @default.
- W4313408085 hasConceptScore W4313408085C2779013556 @default.
- W4313408085 hasConceptScore W4313408085C2779723316 @default.
- W4313408085 hasConceptScore W4313408085C2780192828 @default.
- W4313408085 hasConceptScore W4313408085C2780394083 @default.
- W4313408085 hasConceptScore W4313408085C502942594 @default.
- W4313408085 hasConceptScore W4313408085C54355233 @default.
- W4313408085 hasConceptScore W4313408085C555283112 @default.
- W4313408085 hasConceptScore W4313408085C62112901 @default.
- W4313408085 hasConceptScore W4313408085C62478195 @default.
- W4313408085 hasConceptScore W4313408085C71924100 @default.
- W4313408085 hasConceptScore W4313408085C75217442 @default.
- W4313408085 hasConceptScore W4313408085C84913492 @default.
- W4313408085 hasConceptScore W4313408085C86803240 @default.
- W4313408085 hasConceptScore W4313408085C95444343 @default.
- W4313408085 hasIssue "1_Supplement" @default.
- W4313408085 hasLocation W43134080851 @default.
- W4313408085 hasOpenAccess W4313408085 @default.
- W4313408085 hasPrimaryLocation W43134080851 @default.
- W4313408085 hasRelatedWork W1557020267 @default.
- W4313408085 hasRelatedWork W1606861223 @default.
- W4313408085 hasRelatedWork W1979982236 @default.
- W4313408085 hasRelatedWork W2058903925 @default.
- W4313408085 hasRelatedWork W2091296140 @default.
- W4313408085 hasRelatedWork W2121780359 @default.
- W4313408085 hasRelatedWork W2168676208 @default.
- W4313408085 hasRelatedWork W2391089539 @default.
- W4313408085 hasRelatedWork W3126290430 @default.
- W4313408085 hasRelatedWork W334808203 @default.
- W4313408085 hasVolume "208" @default.
- W4313408085 isParatext "false" @default.
- W4313408085 isRetracted "false" @default.
- W4313408085 workType "article" @default.