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- W4313408089 abstract "Abstract Use of E-cigarettes, also called vaping, has been significantly increasing, with over 10 million adults and 3 million adolescents reported to actively vape. Of particular concern recently is the association of vaping with increased risk of respiratory infection, including influenza and COVID-19. Despite the claims of safety, lung immunological development appears to be impacted by vaping, with associated pulmonary toxicity and potential to impair immunity against respiratory infections. Immunity against respiratory pathogens, particularly viral pathogens is dependent on a robust CD4 and CD8 T cell responses responsible for viral clearance. CD4 and CD8 T cells then develop memory responses to protect against reinfection. T cell memory also provides protection against infection after vaccination. We asked whether vaping exposure affects T cell responses to influenza infection. We exposed animals for 8 weeks to base components of vape devices, including propylene glycol (PG), vegetable glycerin (VG), and a novel cutting agent, phytol, then assessed immune responses to influenza. We find that PGVG and phytol exposure alters pulmonary function, promotes proteomic changes to the lung, and modify immune cell subsets in the lung. We also find that PGVG and phytol exposure alters T cell responses to influenza infection, particularly T cell memory protection against heterologous infection. These results suggest that vaping affects immune responses to respiratory influenza infection, including T cell memory responses. Effects of vaping on T cell memory may have wide ranging consequences for T cell mediated protection against other respiratory disease including SARS-CoV-2 and protection after vaccination. Supported by NIH (P20 GM121176; P20GM130422)" @default.
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- W4313408089 date "2022-05-01" @default.
- W4313408089 modified "2023-09-25" @default.
- W4313408089 title "Effect of E-cigarette use on lung immunity to influenza infection" @default.
- W4313408089 doi "https://doi.org/10.4049/jimmunol.208.supp.182.18" @default.
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