FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313409630> ?p ?o ?g. }

• W4313409630 endingPage "8" @default.
• W4313409630 startingPage "1" @default.
• W4313409630 abstract "Stereotactic radiosurgery (SRS) is an effective treatment for brain metastases (BMs) in patients with non-small cell lung cancer (NSCLC). However, factors associated with the development of post-SRS leptomeningeal metastasis (LM) remain unclear. The authors analyzed the incidence and risk factors of LM development in patients with NSCLC and BMs after SRS and examined the survival outcomes and prognostic factors after LM development.This retrospective study included patients with NSCLC treated with SRS for MRI-diagnosed BM from 2002 to 2021. The authors recorded various clinical and demographic data, including age, sex, tumor histology, molecular profile of tumors, extracranial disease status, previous craniotomy, Karnofsky Performance Status, systemic treatments, tumor volume, and number of BMs. The management and survival outcomes after LM diagnosis were also recorded.LM developed in 13.7% of patients with NSCLC and BMs after SRS treatment. Large initial tumor volume and more than 5 BM lesions, but not EGFR mutation status and post-SRS treatment, were associated with LM development after SRS. Multivariate analysis revealed that chemotherapy and targeted therapy after LM were associated with better survival in patients with LM after SRS.This study is the first to evaluate the risk factors for LM in a relatively large cohort of patients with NSCLC after SRS. In patients with BMs harboring risk factors for subsequent LM, such as initial tumor volume and number of metastatic lesions, aggressive therapies with high CNS penetrating ability should be considered." @default.
• W4313409630 created "2023-01-06" @default.
• W4313409630 creator A5001959228 @default.
• W4313409630 creator A5006288322 @default.
• W4313409630 creator A5006571598 @default.
• W4313409630 creator A5013170925 @default.
• W4313409630 creator A5028055906 @default.
• W4313409630 creator A5034045693 @default.
• W4313409630 creator A5035839892 @default.
• W4313409630 creator A5036194808 @default.
• W4313409630 creator A5036213171 @default.
• W4313409630 creator A5046359356 @default.
• W4313409630 creator A5059303705 @default.
• W4313409630 creator A5063738165 @default.
• W4313409630 creator A5073304690 @default.
• W4313409630 creator A5074737496 @default.
• W4313409630 date "2022-12-01" @default.
• W4313409630 modified "2023-10-02" @default.
• W4313409630 title "Leptomeningeal metastasis in patients with non–small cell lung cancer after stereotactic radiosurgery for brain metastasis" @default.
• W4313409630 cites W2041835001 @default.
• W4313409630 cites W2059336382 @default.
• W4313409630 cites W2083128109 @default.
• W4313409630 cites W2102644677 @default.
• W4313409630 cites W2127465345 @default.
• W4313409630 cites W2128871519 @default.
• W4313409630 cites W2147840374 @default.
• W4313409630 cites W2168888547 @default.
• W4313409630 cites W2206655113 @default.
• W4313409630 cites W2250209474 @default.
• W4313409630 cites W2513221119 @default.
• W4313409630 cites W2561905602 @default.
• W4313409630 cites W2734482945 @default.
• W4313409630 cites W2770610674 @default.
• W4313409630 cites W2773746284 @default.
• W4313409630 cites W2776743180 @default.
• W4313409630 cites W2888391264 @default.
• W4313409630 cites W2901138404 @default.
• W4313409630 cites W2918189147 @default.
• W4313409630 cites W2930569756 @default.
• W4313409630 cites W2944856593 @default.
• W4313409630 cites W2954312165 @default.
• W4313409630 cites W2966974286 @default.
• W4313409630 cites W2990246067 @default.
• W4313409630 cites W3042182682 @default.
• W4313409630 cites W3172623270 @default.
• W4313409630 cites W3186843975 @default.
• W4313409630 cites W4200372541 @default.
• W4313409630 doi "https://doi.org/10.3171/2022.11.jns221888" @default.
• W4313409630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36681978" @default.
• W4313409630 hasPublicationYear "2022" @default.
• W4313409630 type Work @default.
• W4313409630 citedByCount "1" @default.
• W4313409630 countsByYear W43134096302023 @default.
• W4313409630 crossrefType "journal-article" @default.
• W4313409630 hasAuthorship W4313409630A5001959228 @default.
• W4313409630 hasAuthorship W4313409630A5006288322 @default.
• W4313409630 hasAuthorship W4313409630A5006571598 @default.
• W4313409630 hasAuthorship W4313409630A5013170925 @default.
• W4313409630 hasAuthorship W4313409630A5028055906 @default.
• W4313409630 hasAuthorship W4313409630A5034045693 @default.
• W4313409630 hasAuthorship W4313409630A5035839892 @default.
• W4313409630 hasAuthorship W4313409630A5036194808 @default.
• W4313409630 hasAuthorship W4313409630A5036213171 @default.
• W4313409630 hasAuthorship W4313409630A5046359356 @default.
• W4313409630 hasAuthorship W4313409630A5059303705 @default.
• W4313409630 hasAuthorship W4313409630A5063738165 @default.
• W4313409630 hasAuthorship W4313409630A5073304690 @default.
• W4313409630 hasAuthorship W4313409630A5074737496 @default.
• W4313409630 hasConcept C121608353 @default.
• W4313409630 hasConcept C126322002 @default.
• W4313409630 hasConcept C126838900 @default.
• W4313409630 hasConcept C143998085 @default.
• W4313409630 hasConcept C167135981 @default.
• W4313409630 hasConcept C2776256026 @default.
• W4313409630 hasConcept C2776694085 @default.
• W4313409630 hasConcept C2776907518 @default.
• W4313409630 hasConcept C2778164965 @default.
• W4313409630 hasConcept C2778871575 @default.
• W4313409630 hasConcept C2779013556 @default.
• W4313409630 hasConcept C2780387249 @default.
• W4313409630 hasConcept C38180746 @default.
• W4313409630 hasConcept C509974204 @default.
• W4313409630 hasConcept C71924100 @default.
• W4313409630 hasConceptScore W4313409630C121608353 @default.
• W4313409630 hasConceptScore W4313409630C126322002 @default.
• W4313409630 hasConceptScore W4313409630C126838900 @default.
• W4313409630 hasConceptScore W4313409630C143998085 @default.
• W4313409630 hasConceptScore W4313409630C167135981 @default.
• W4313409630 hasConceptScore W4313409630C2776256026 @default.
• W4313409630 hasConceptScore W4313409630C2776694085 @default.
• W4313409630 hasConceptScore W4313409630C2776907518 @default.
• W4313409630 hasConceptScore W4313409630C2778164965 @default.
• W4313409630 hasConceptScore W4313409630C2778871575 @default.
• W4313409630 hasConceptScore W4313409630C2779013556 @default.
• W4313409630 hasConceptScore W4313409630C2780387249 @default.
• W4313409630 hasConceptScore W4313409630C38180746 @default.
• W4313409630 hasConceptScore W4313409630C509974204 @default.
• W4313409630 hasConceptScore W4313409630C71924100 @default.

• next