FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313409675> ?p ?o ?g. }

• W4313409675 endingPage "585" @default.
• W4313409675 startingPage "585" @default.
• W4313409675 abstract "Molecular mechanisms underlying the diverse therapeutic effects of anti-diabetic metformin, beyond its anti-hyperglycaemic effects, remain largely unclear. Metformin is reported to reduce the long-term complications of diabetes, including cardiovascular fibrosis and remodelling. Our recent investigations show that Discoidin Domain Receptor 2 (DDR2), a Collagen receptor tyrosine kinase, has an obligate regulatory role in Collagen type I gene expression in cardiac and vascular adventitial fibroblasts, and that it may be a molecular link between arterial fibrosis and metabolic syndrome in rhesus monkeys. Using gene knockdown and overexpression approaches, the present study examined whether DDR2 is a target of metformin and whether, by targeting DDR2, it inhibits Fibronectin and Collagen type I expression in rat aortic adventitial fibroblasts exposed to hyperglycaemic conditions. Metformin was found to attenuate hyperglycaemia-induced increase in DDR2 mRNA and protein expression by inhibiting TGF-β1/SMAD2/3 signalling that mediates the stimulatory effect of hyperglycaemia on DDR2 expression. Metformin also inhibited DDR2-dependent expression of Fibronectin and Collagen type I, indicating that it regulates these matrix proteins via DDR2 inhibition. The findings identify DDR2, a mediator of cardiovascular remodelling, as a molecular target of metformin, thereby uncovering the molecular basis of its protective role in vascular fibrosis and possibly cardiac fibrosis associated with diabetic cardiomyopathy." @default.
• W4313409675 created "2023-01-06" @default.
• W4313409675 creator A5006074435 @default.
• W4313409675 creator A5007467292 @default.
• W4313409675 creator A5023940206 @default.
• W4313409675 creator A5045563275 @default.
• W4313409675 creator A5056447527 @default.
• W4313409675 creator A5077932215 @default.
• W4313409675 date "2022-12-29" @default.
• W4313409675 modified "2023-10-18" @default.
• W4313409675 title "Metformin Attenuates Hyperglycaemia-Stimulated Pro-Fibrotic Gene Expression in Adventitial Fibroblasts via Inhibition of Discoidin Domain Receptor 2" @default.
• W4313409675 cites W1969375564 @default.
• W4313409675 cites W1980106834 @default.
• W4313409675 cites W2012379094 @default.
• W4313409675 cites W2020474316 @default.
• W4313409675 cites W2027044540 @default.
• W4313409675 cites W2030075504 @default.
• W4313409675 cites W2105665055 @default.
• W4313409675 cites W2118941667 @default.
• W4313409675 cites W2136386001 @default.
• W4313409675 cites W2148489323 @default.
• W4313409675 cites W2159836415 @default.
• W4313409675 cites W2165179571 @default.
• W4313409675 cites W2167279371 @default.
• W4313409675 cites W2169117904 @default.
• W4313409675 cites W2194511984 @default.
• W4313409675 cites W2461650599 @default.
• W4313409675 cites W2534249013 @default.
• W4313409675 cites W2571035512 @default.
• W4313409675 cites W2747084217 @default.
• W4313409675 cites W2769553340 @default.
• W4313409675 cites W2794128897 @default.
• W4313409675 cites W2797060729 @default.
• W4313409675 cites W2797835639 @default.
• W4313409675 cites W2800981650 @default.
• W4313409675 cites W2914902752 @default.
• W4313409675 cites W2955212273 @default.
• W4313409675 cites W2987944969 @default.
• W4313409675 cites W2994283297 @default.
• W4313409675 cites W3020412742 @default.
• W4313409675 cites W3023241761 @default.
• W4313409675 cites W3025474635 @default.
• W4313409675 cites W3084346878 @default.
• W4313409675 cites W3158336089 @default.
• W4313409675 cites W3196885947 @default.
• W4313409675 cites W3198342300 @default.
• W4313409675 cites W4207065877 @default.
• W4313409675 cites W4236147141 @default.
• W4313409675 doi "https://doi.org/10.3390/ijms24010585" @default.
• W4313409675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36614028" @default.
• W4313409675 hasPublicationYear "2022" @default.
• W4313409675 type Work @default.
• W4313409675 citedByCount "3" @default.
• W4313409675 countsByYear W43134096752023 @default.
• W4313409675 crossrefType "journal-article" @default.
• W4313409675 hasAuthorship W4313409675A5006074435 @default.
• W4313409675 hasAuthorship W4313409675A5007467292 @default.
• W4313409675 hasAuthorship W4313409675A5023940206 @default.
• W4313409675 hasAuthorship W4313409675A5045563275 @default.
• W4313409675 hasAuthorship W4313409675A5056447527 @default.
• W4313409675 hasAuthorship W4313409675A5077932215 @default.
• W4313409675 hasBestOaLocation W43134096751 @default.
• W4313409675 hasConcept C101544691 @default.
• W4313409675 hasConcept C104317684 @default.
• W4313409675 hasConcept C126322002 @default.
• W4313409675 hasConcept C134018914 @default.
• W4313409675 hasConcept C152681006 @default.
• W4313409675 hasConcept C170493617 @default.
• W4313409675 hasConcept C173396325 @default.
• W4313409675 hasConcept C189165786 @default.
• W4313409675 hasConcept C2776305115 @default.
• W4313409675 hasConcept C2780323712 @default.
• W4313409675 hasConcept C2780559512 @default.
• W4313409675 hasConcept C502942594 @default.
• W4313409675 hasConcept C55493867 @default.
• W4313409675 hasConcept C555293320 @default.
• W4313409675 hasConcept C71924100 @default.
• W4313409675 hasConcept C86492073 @default.
• W4313409675 hasConcept C86803240 @default.
• W4313409675 hasConcept C95444343 @default.
• W4313409675 hasConceptScore W4313409675C101544691 @default.
• W4313409675 hasConceptScore W4313409675C104317684 @default.
• W4313409675 hasConceptScore W4313409675C126322002 @default.
• W4313409675 hasConceptScore W4313409675C134018914 @default.
• W4313409675 hasConceptScore W4313409675C152681006 @default.
• W4313409675 hasConceptScore W4313409675C170493617 @default.
• W4313409675 hasConceptScore W4313409675C173396325 @default.
• W4313409675 hasConceptScore W4313409675C189165786 @default.
• W4313409675 hasConceptScore W4313409675C2776305115 @default.
• W4313409675 hasConceptScore W4313409675C2780323712 @default.
• W4313409675 hasConceptScore W4313409675C2780559512 @default.
• W4313409675 hasConceptScore W4313409675C502942594 @default.
• W4313409675 hasConceptScore W4313409675C55493867 @default.
• W4313409675 hasConceptScore W4313409675C555293320 @default.
• W4313409675 hasConceptScore W4313409675C71924100 @default.
• W4313409675 hasConceptScore W4313409675C86492073 @default.
• W4313409675 hasConceptScore W4313409675C86803240 @default.
• W4313409675 hasConceptScore W4313409675C95444343 @default.

• next