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- W4313410169 endingPage "13" @default.
- W4313410169 startingPage "1" @default.
- W4313410169 abstract "8-Oxoguanine DNA glycosylase (OGG1) is a repair protein for 8-oxoguanine (8-oxoG) in eukaryotic atopic DNA. Through the initial base excision repair (BER) pathway, 8-oxoG is recognized and excised, and subsequently, other proteins are recruited to complete the repair. OGG1 is primarily located in the cytoplasm and can enter the nucleus and mitochondria to repair damaged DNA or to exert epigenetic regulation of gene transcription. OGG1 is involved in a wide range of physiological processes, such as DNA repair, oxidative stress, inflammation, fibrosis, and autophagy. In recent years, studies have found that OGG1 plays an important role in the progression of kidney diseases through repairing DNA, inducing inflammation, regulating autophagy and other transcriptional regulation, and governing protein interactions and functions during disease and injury. In particular, the epigenetic effects of OGG1 in kidney disease have gradually attracted widespread attention. This study reviews the structure and biological functions of OGG1 and the regulatory mechanism of OGG1 in kidney disease. In addition, the possibility of OGG1 as a potential therapeutic target in kidney disease is discussed." @default.
- W4313410169 created "2023-01-06" @default.
- W4313410169 creator A5038561295 @default.
- W4313410169 creator A5042277520 @default.
- W4313410169 creator A5048779642 @default.
- W4313410169 creator A5089722771 @default.
- W4313410169 date "2022-12-30" @default.
- W4313410169 modified "2023-10-04" @default.
- W4313410169 title "OGG1 in the Kidney: Beyond Base Excision Repair" @default.
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