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• W4313413847 abstract "The general improvement in life expectancy and standard of living makes it easier for patients to get access to routine medical exams and is anticipated to increase the prevalence of several degenerative joint illnesses. In addition, it is anticipated that their incidence will increase both nationally and internationally, which will raise the demand for novel and long-lasting implantable devices in the field of orthopedics. The current review’s goals are to define what constitutes a biocompatible orthopedic implant in terms of in vitro biocompatibility testing and to clarify important concepts and definitions that are already in use. The demand for materials and implants made of various tissues is now increasing, and the ongoing advancement of in vitro cell culture studies is a reliable practical tool for examining the biocompatibility of potential implantable materials. In vitro biocompatibility research has been reduced and, in most cases, diminished to laboratory studies that no longer or drastically reduce animal sacrifice as a response to the well-known three “Rs” (“reduction”, “refinement”, and “replacement”) introduced to literature by English academics in the 1960s. As technology advances at an astounding rate, a new generation of gene-activating biomaterials tailored for specific people and disease conditions might emerge in the near future." @default.
• W4313413847 created "2023-01-06" @default.
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• W4313413847 date "2022-12-27" @default.
• W4313413847 modified "2023-10-18" @default.
• W4313413847 title "From Basic Science to Clinical Perfection: What Defines the Orthopedic Biocompatible Implant?" @default.
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• W4313413847 doi "https://doi.org/10.3390/surgeries4010001" @default.
• W4313413847 hasPublicationYear "2022" @default.
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