FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313414303> ?p ?o ?g. }

• W4313414303 endingPage "42" @default.
• W4313414303 startingPage "42" @default.
• W4313414303 abstract "Berberine hydrochloride (BBR) could inhibit the proliferation, migration, and invasion of various cancer cells. As the only enzyme for the de novo synthesis of ribonucleotides, RRM2 is closely related to the development of tumorigenesis. However, not much is currently known about the functional roles of RRM2 in breast cancer (BRCA), and whether BBR regulates the migration and invasion of BRCA cells by regulating the expression of RRM2 remains to be determined. We study the effects of BBR on BRCA cell proliferation in vitro and tumorigenesis in vivo by using colony formation assays, EdU assays, and xenograft models. Transcriptome sequencing, the random forest algorithm, and KEGG analysis were utilized to explore the therapeutic target genes and relative pathways. The expression of RRM2 in BRCA patients was analyzed with The Cancer Genome Atlas (TCGA) dataset, the GEPIA website tool, the Gene Expression Omnibus (GEO) database, and the UALCAN database. The survival probability of BRCA patients could be predicted by survival curve and nomogram analysis. Molecular docking was used to explore the affinity between BBR and potential targets. Gain- and loss-of-function methods were employed to explore the biological process in RRM2 participants. We comprehensively investigated the pharmacological characteristics of BBR on BRCA cell lines and discovered that BBR could inhibit the proliferation of BRCA cells in vitro and in vivo. Combining transcriptome sequencing and KEGG analysis, we found that BBR mainly affected the biological behavior of BRCA cells via HIF-1α and AMPK signal pathways. Additionally, by using bioinformatics and molecular docking, we demonstrated that RRM2 plays an oncogenic role in BRCA samples and that it acts as the hub gene of BBR on BRCA cells. Knockdown and overexpression studies indicated that RRM2 promoted BRCA cell migration as well as invasion in vitro by affecting the epithelial-to-mesenchymal transition (EMT). Our study demonstrated the significance of BBR regulating HIF-1α and AMPK signaling pathways in BRCA cells. Moreover, we revealed the carcinogenic role and potential mechanism of RRM2 as a core regulatory factor of BBR in BRCA in controlling BRCA invasion, migration, and EMT, suggesting that RRM2 may be a therapeutic target and prognostic biomarker for BRCA therapy." @default.
• W4313414303 created "2023-01-06" @default.
• W4313414303 creator A5012677271 @default.
• W4313414303 creator A5020702800 @default.
• W4313414303 creator A5052729067 @default.
• W4313414303 creator A5053260700 @default.
• W4313414303 creator A5056464919 @default.
• W4313414303 creator A5057158151 @default.
• W4313414303 creator A5068672758 @default.
• W4313414303 creator A5074517429 @default.
• W4313414303 creator A5077576765 @default.
• W4313414303 creator A5079666766 @default.
• W4313414303 date "2022-12-28" @default.
• W4313414303 modified "2023-10-14" @default.
• W4313414303 title "The Core-Targeted RRM2 Gene of Berberine Hydrochloride Promotes Breast Cancer Cell Migration and Invasion via the Epithelial–Mesenchymal Transition" @default.
• W4313414303 cites W1971403257 @default.
• W4313414303 cites W1973109316 @default.
• W4313414303 cites W1992548225 @default.
• W4313414303 cites W1997534577 @default.
• W4313414303 cites W2047167565 @default.
• W4313414303 cites W2068602827 @default.
• W4313414303 cites W2085946564 @default.
• W4313414303 cites W2130410032 @default.
• W4313414303 cites W2134967712 @default.
• W4313414303 cites W2142786915 @default.
• W4313414303 cites W2149464340 @default.
• W4313414303 cites W2462514513 @default.
• W4313414303 cites W2552872119 @default.
• W4313414303 cites W2594247592 @default.
• W4313414303 cites W2598984757 @default.
• W4313414303 cites W2745124429 @default.
• W4313414303 cites W2745883742 @default.
• W4313414303 cites W2793984701 @default.
• W4313414303 cites W2802736231 @default.
• W4313414303 cites W2906067435 @default.
• W4313414303 cites W2912993657 @default.
• W4313414303 cites W2915117958 @default.
• W4313414303 cites W2936048640 @default.
• W4313414303 cites W2978169388 @default.
• W4313414303 cites W2981134993 @default.
• W4313414303 cites W2981703582 @default.
• W4313414303 cites W2984023220 @default.
• W4313414303 cites W2996768377 @default.
• W4313414303 cites W2999417355 @default.
• W4313414303 cites W3007238079 @default.
• W4313414303 cites W3010259062 @default.
• W4313414303 cites W3021890058 @default.
• W4313414303 cites W3023752815 @default.
• W4313414303 cites W3037136310 @default.
• W4313414303 cites W3041259235 @default.
• W4313414303 cites W3082891477 @default.
• W4313414303 cites W3095458791 @default.
• W4313414303 cites W3107285902 @default.
• W4313414303 cites W3116283216 @default.
• W4313414303 cites W3128646645 @default.
• W4313414303 cites W3137390645 @default.
• W4313414303 cites W3155260693 @default.
• W4313414303 cites W3172112494 @default.
• W4313414303 cites W3185428240 @default.
• W4313414303 cites W3196645117 @default.
• W4313414303 cites W3205916516 @default.
• W4313414303 cites W4200153679 @default.
• W4313414303 cites W4206759465 @default.
• W4313414303 cites W4220726198 @default.
• W4313414303 cites W4280633125 @default.
• W4313414303 doi "https://doi.org/10.3390/ph16010042" @default.
• W4313414303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36678539" @default.
• W4313414303 hasPublicationYear "2022" @default.
• W4313414303 type Work @default.
• W4313414303 citedByCount "1" @default.
• W4313414303 crossrefType "journal-article" @default.
• W4313414303 hasAuthorship W4313414303A5012677271 @default.
• W4313414303 hasAuthorship W4313414303A5020702800 @default.
• W4313414303 hasAuthorship W4313414303A5052729067 @default.
• W4313414303 hasAuthorship W4313414303A5053260700 @default.
• W4313414303 hasAuthorship W4313414303A5056464919 @default.
• W4313414303 hasAuthorship W4313414303A5057158151 @default.
• W4313414303 hasAuthorship W4313414303A5068672758 @default.
• W4313414303 hasAuthorship W4313414303A5074517429 @default.
• W4313414303 hasAuthorship W4313414303A5077576765 @default.
• W4313414303 hasAuthorship W4313414303A5079666766 @default.
• W4313414303 hasBestOaLocation W43134143031 @default.
• W4313414303 hasConcept C104317684 @default.
• W4313414303 hasConcept C121608353 @default.
• W4313414303 hasConcept C150194340 @default.
• W4313414303 hasConcept C152724338 @default.
• W4313414303 hasConcept C162317418 @default.
• W4313414303 hasConcept C502942594 @default.
• W4313414303 hasConcept C530470458 @default.
• W4313414303 hasConcept C54355233 @default.
• W4313414303 hasConcept C555283112 @default.
• W4313414303 hasConcept C62112901 @default.
• W4313414303 hasConcept C70721500 @default.
• W4313414303 hasConcept C86803240 @default.
• W4313414303 hasConceptScore W4313414303C104317684 @default.
• W4313414303 hasConceptScore W4313414303C121608353 @default.
• W4313414303 hasConceptScore W4313414303C150194340 @default.
• W4313414303 hasConceptScore W4313414303C152724338 @default.

• next