Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313424427> ?p ?o ?g. }
- W4313424427 abstract "Fungal hyphae deeply invade the cornea in fungal keratitis. The corneal stroma hinders the infiltration of antifungal drugs and reduces their bioavailability. Here, this work reports a peptide conjugate nano-assembly that permeates the stroma and kills the pathogen without irritating the ocular cornea. The hydrophilic surface of the nano-assembly ensures deep permeation into the stroma. When encountering a fungal hyphal cell, the nano-assembly disassembles and exposes the α-helical peptide to destroy the fungal membrane, thus inactivating the pathogen. In a rabbit model of fungal keratitis, the nano-assembly exhibits a better therapeutic effect than commercially available natamycin ophthalmic suspension. Peptide conjugates with a nano-assembled structure and assembly-disassembly behavior could serve as the foundation of a new therapy for fungal keratitis." @default.
- W4313424427 created "2023-01-06" @default.
- W4313424427 creator A5016996911 @default.
- W4313424427 creator A5028165423 @default.
- W4313424427 creator A5029858194 @default.
- W4313424427 creator A5033149120 @default.
- W4313424427 creator A5042185034 @default.
- W4313424427 creator A5055027710 @default.
- W4313424427 creator A5061227817 @default.
- W4313424427 creator A5081717691 @default.
- W4313424427 creator A5088657051 @default.
- W4313424427 date "2023-01-15" @default.
- W4313424427 modified "2023-10-17" @default.
- W4313424427 title "Overcoming the Stromal Barrier of the Cornea with a Peptide Conjugate Nano‐Assembly to Combat Fungal Keratitis" @default.
- W4313424427 cites W1423075642 @default.
- W4313424427 cites W1965336009 @default.
- W4313424427 cites W1967332510 @default.
- W4313424427 cites W1977348918 @default.
- W4313424427 cites W1981652223 @default.
- W4313424427 cites W1991488616 @default.
- W4313424427 cites W1997437177 @default.
- W4313424427 cites W1999340863 @default.
- W4313424427 cites W2116582646 @default.
- W4313424427 cites W2124902962 @default.
- W4313424427 cites W2551752994 @default.
- W4313424427 cites W2571828759 @default.
- W4313424427 cites W2607165634 @default.
- W4313424427 cites W2738403659 @default.
- W4313424427 cites W2747277042 @default.
- W4313424427 cites W2747374014 @default.
- W4313424427 cites W2787896129 @default.
- W4313424427 cites W2803366880 @default.
- W4313424427 cites W2972139195 @default.
- W4313424427 cites W2978598381 @default.
- W4313424427 cites W2981240979 @default.
- W4313424427 cites W3010204060 @default.
- W4313424427 cites W3011368517 @default.
- W4313424427 cites W3081128151 @default.
- W4313424427 cites W3094023869 @default.
- W4313424427 cites W3206382143 @default.
- W4313424427 cites W4200075298 @default.
- W4313424427 cites W4200270183 @default.
- W4313424427 cites W4212843667 @default.
- W4313424427 doi "https://doi.org/10.1002/adhm.202202409" @default.
- W4313424427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36588425" @default.
- W4313424427 hasPublicationYear "2023" @default.
- W4313424427 type Work @default.
- W4313424427 citedByCount "0" @default.
- W4313424427 crossrefType "journal-article" @default.
- W4313424427 hasAuthorship W4313424427A5016996911 @default.
- W4313424427 hasAuthorship W4313424427A5028165423 @default.
- W4313424427 hasAuthorship W4313424427A5029858194 @default.
- W4313424427 hasAuthorship W4313424427A5033149120 @default.
- W4313424427 hasAuthorship W4313424427A5042185034 @default.
- W4313424427 hasAuthorship W4313424427A5055027710 @default.
- W4313424427 hasAuthorship W4313424427A5061227817 @default.
- W4313424427 hasAuthorship W4313424427A5081717691 @default.
- W4313424427 hasAuthorship W4313424427A5088657051 @default.
- W4313424427 hasConcept C134306372 @default.
- W4313424427 hasConcept C169760540 @default.
- W4313424427 hasConcept C192562407 @default.
- W4313424427 hasConcept C197336794 @default.
- W4313424427 hasConcept C203014093 @default.
- W4313424427 hasConcept C204232928 @default.
- W4313424427 hasConcept C2776079991 @default.
- W4313424427 hasConcept C2776460866 @default.
- W4313424427 hasConcept C2776882836 @default.
- W4313424427 hasConcept C2778560704 @default.
- W4313424427 hasConcept C2779117757 @default.
- W4313424427 hasConcept C2779257441 @default.
- W4313424427 hasConcept C2779281246 @default.
- W4313424427 hasConcept C2909898526 @default.
- W4313424427 hasConcept C3019170707 @default.
- W4313424427 hasConcept C31903555 @default.
- W4313424427 hasConcept C33923547 @default.
- W4313424427 hasConcept C52124034 @default.
- W4313424427 hasConcept C54355233 @default.
- W4313424427 hasConcept C55493867 @default.
- W4313424427 hasConcept C86803240 @default.
- W4313424427 hasConcept C89423630 @default.
- W4313424427 hasConcept C90080823 @default.
- W4313424427 hasConceptScore W4313424427C134306372 @default.
- W4313424427 hasConceptScore W4313424427C169760540 @default.
- W4313424427 hasConceptScore W4313424427C192562407 @default.
- W4313424427 hasConceptScore W4313424427C197336794 @default.
- W4313424427 hasConceptScore W4313424427C203014093 @default.
- W4313424427 hasConceptScore W4313424427C204232928 @default.
- W4313424427 hasConceptScore W4313424427C2776079991 @default.
- W4313424427 hasConceptScore W4313424427C2776460866 @default.
- W4313424427 hasConceptScore W4313424427C2776882836 @default.
- W4313424427 hasConceptScore W4313424427C2778560704 @default.
- W4313424427 hasConceptScore W4313424427C2779117757 @default.
- W4313424427 hasConceptScore W4313424427C2779257441 @default.
- W4313424427 hasConceptScore W4313424427C2779281246 @default.
- W4313424427 hasConceptScore W4313424427C2909898526 @default.
- W4313424427 hasConceptScore W4313424427C3019170707 @default.
- W4313424427 hasConceptScore W4313424427C31903555 @default.
- W4313424427 hasConceptScore W4313424427C33923547 @default.
- W4313424427 hasConceptScore W4313424427C52124034 @default.
- W4313424427 hasConceptScore W4313424427C54355233 @default.