FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313430032> ?p ?o ?g. }

• W4313430032 endingPage "241" @default.
• W4313430032 startingPage "233" @default.
• W4313430032 abstract "Programmed cell death ligand 1 (PD-L1) is an immune checkpoint protein involved in immune evasion of malignant tumors. Confirmation of PD-L1 expression in non-small cell lung cancer (NSCLC) is necessary for the determination of immunotherapy using immune checkpoint inhibitors (ICIs). PDL-1 expression is currently analyzed by immunohistochemistry and is the only available biomarker that can guide the treatment of NSCLC using ICIs. The present study was conducted to compare the expression of three different commercial clones of PD-L1 in order for immunohistochemistry (IHC) for these clones to become more reliable for surgical pathologists.This study examined the expression of PD-L1 in 76 cases of resected lung cancer using IHC. Three clones were examined: SP263, SP142, and 22C3PharmDx, which are commercially approved for quantifying PD-L1 expression in lung cancer.Of the 76 patients whose samples were evaluated for PD-L1 using the IHC 22C3pharmDx assay, 19 (25.0%) had a tumor proportion score (TPS) of ≥50% and 41 (53.9%) had a PD-L1 TPS of ≥1%. Furthermore, using the SP263, 48.7% had a TPS of ≥1% and 18.4% of >50%. The SP142 assay was used to evaluate tumor cells (TCs) and immune cells (ICs). Twenty (26.3%) cases were positive for TCs and 25 (32.9%) were reactive for ICs.These three commercial PD-L1 clones are comparable for detecting primary targets for anti-tumor immunotherapies. Careful evaluation by a pathologist is necessary to minimize misinterpretation errors." @default.
• W4313430032 created "2023-01-06" @default.
• W4313430032 creator A5026179941 @default.
• W4313430032 creator A5050604864 @default.
• W4313430032 creator A5060378824 @default.
• W4313430032 creator A5085158699 @default.
• W4313430032 date "2023-01-01" @default.
• W4313430032 modified "2023-10-14" @default.
• W4313430032 title "Expression of Three Clones of PD-L1 in Lung Cancer: A Single-center Experience" @default.
• W4313430032 cites W1591338264 @default.
• W4313430032 cites W1977912929 @default.
• W4313430032 cites W2003417210 @default.
• W4313430032 cites W2046972425 @default.
• W4313430032 cites W2059697019 @default.
• W4313430032 cites W2066002010 @default.
• W4313430032 cites W2066671159 @default.
• W4313430032 cites W2101653483 @default.
• W4313430032 cites W2146781227 @default.
• W4313430032 cites W2147415023 @default.
• W4313430032 cites W2156383220 @default.
• W4313430032 cites W2160834915 @default.
• W4313430032 cites W2164842455 @default.
• W4313430032 cites W2289528730 @default.
• W4313430032 cites W2405058420 @default.
• W4313430032 cites W2557730509 @default.
• W4313430032 cites W2560367415 @default.
• W4313430032 cites W2604610427 @default.
• W4313430032 cites W2606367731 @default.
• W4313430032 cites W2738111927 @default.
• W4313430032 cites W2745207660 @default.
• W4313430032 cites W2751649617 @default.
• W4313430032 cites W2935497219 @default.
• W4313430032 cites W2943616628 @default.
• W4313430032 cites W3149526972 @default.
• W4313430032 cites W4214918016 @default.
• W4313430032 doi "https://doi.org/10.21873/invivo.13072" @default.
• W4313430032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36593005" @default.
• W4313430032 hasPublicationYear "2023" @default.
• W4313430032 type Work @default.
• W4313430032 citedByCount "0" @default.
• W4313430032 crossrefType "journal-article" @default.
• W4313430032 hasAuthorship W4313430032A5026179941 @default.
• W4313430032 hasAuthorship W4313430032A5050604864 @default.
• W4313430032 hasAuthorship W4313430032A5060378824 @default.
• W4313430032 hasAuthorship W4313430032A5085158699 @default.
• W4313430032 hasBestOaLocation W43134300321 @default.
• W4313430032 hasConcept C121608353 @default.
• W4313430032 hasConcept C126322002 @default.
• W4313430032 hasConcept C142724271 @default.
• W4313430032 hasConcept C143998085 @default.
• W4313430032 hasConcept C159654299 @default.
• W4313430032 hasConcept C203014093 @default.
• W4313430032 hasConcept C204232928 @default.
• W4313430032 hasConcept C2776256026 @default.
• W4313430032 hasConcept C2777701055 @default.
• W4313430032 hasConcept C2780674031 @default.
• W4313430032 hasConcept C2780851360 @default.
• W4313430032 hasConcept C2781053074 @default.
• W4313430032 hasConcept C2781197716 @default.
• W4313430032 hasConcept C502942594 @default.
• W4313430032 hasConcept C55493867 @default.
• W4313430032 hasConcept C71924100 @default.
• W4313430032 hasConcept C86803240 @default.
• W4313430032 hasConcept C8891405 @default.
• W4313430032 hasConceptScore W4313430032C121608353 @default.
• W4313430032 hasConceptScore W4313430032C126322002 @default.
• W4313430032 hasConceptScore W4313430032C142724271 @default.
• W4313430032 hasConceptScore W4313430032C143998085 @default.
• W4313430032 hasConceptScore W4313430032C159654299 @default.
• W4313430032 hasConceptScore W4313430032C203014093 @default.
• W4313430032 hasConceptScore W4313430032C204232928 @default.
• W4313430032 hasConceptScore W4313430032C2776256026 @default.
• W4313430032 hasConceptScore W4313430032C2777701055 @default.
• W4313430032 hasConceptScore W4313430032C2780674031 @default.
• W4313430032 hasConceptScore W4313430032C2780851360 @default.
• W4313430032 hasConceptScore W4313430032C2781053074 @default.
• W4313430032 hasConceptScore W4313430032C2781197716 @default.
• W4313430032 hasConceptScore W4313430032C502942594 @default.
• W4313430032 hasConceptScore W4313430032C55493867 @default.
• W4313430032 hasConceptScore W4313430032C71924100 @default.
• W4313430032 hasConceptScore W4313430032C86803240 @default.
• W4313430032 hasConceptScore W4313430032C8891405 @default.
• W4313430032 hasIssue "1" @default.
• W4313430032 hasLocation W43134300321 @default.
• W4313430032 hasLocation W43134300322 @default.
• W4313430032 hasLocation W43134300323 @default.
• W4313430032 hasOpenAccess W4313430032 @default.
• W4313430032 hasPrimaryLocation W43134300321 @default.
• W4313430032 hasRelatedWork W2400599632 @default.
• W4313430032 hasRelatedWork W2761992239 @default.
• W4313430032 hasRelatedWork W2806333505 @default.
• W4313430032 hasRelatedWork W2893846263 @default.
• W4313430032 hasRelatedWork W2999675030 @default.
• W4313430032 hasRelatedWork W3049036915 @default.
• W4313430032 hasRelatedWork W3111580887 @default.
• W4313430032 hasRelatedWork W3185708072 @default.
• W4313430032 hasRelatedWork W4223914026 @default.
• W4313430032 hasRelatedWork W4313343001 @default.

• next