Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313430106> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4313430106 endingPage "51.02" @default.
- W4313430106 startingPage "51.02" @default.
- W4313430106 abstract "Abstract Neonatal meningitis-associated Escherichia coli (NMEC) are among the leading causes of bacterial meningitis and sepsis in newborn infants. Several virulence factors have been identified as common among NMEC, and have been shown to play an important role in the development of bacteremia and/or meningitis. However, there is significant variability in virulence factor expression between NMEC isolates, and relatively little research has been done to assess the impact of variable virulence factor expression on immune cell activation and the outcome of infection. Here we investigated the role of NMEC strain-dependent P2X receptor (P2XR) signaling on the outcome of infection in neonatal mice. We found that alpha hemolysin (HlyA)-expressing NMEC (HlyA+) induced robust P2XR-dependent macrophage cell death in vitro, while HlyA− NMEC did not. P2XR-dependent cell death was inflammasome independent, suggesting an uncoupling of P2XR and inflammasome activation in the context of NMEC infection. In vivo inhibition of P2XRs was associated with increased mortality in neonatal mice infected with HlyA+ NMEC, but had no effect on the survival of neonatal mice infected with HlyA− NMEC. Furthermore, we found that P2XR-dependent protection against HlyA+ NMEC in vivo required macrophages, but not neutrophils or NLRP3. Taken together, these data suggest that HlyA+ NMEC activate P2XRs which in turn confers macrophage dependent protection against infection in neonates. In addition, our findings indicate that strain-dependent virulence factor expression should be taken into account when studying the immune response to NMEC. Supported by University of Missouri College of Veterinary Medicine Committee on Research." @default.
- W4313430106 created "2023-01-06" @default.
- W4313430106 creator A5007031588 @default.
- W4313430106 creator A5024971127 @default.
- W4313430106 creator A5050187189 @default.
- W4313430106 creator A5066864788 @default.
- W4313430106 creator A5075350104 @default.
- W4313430106 creator A5082144037 @default.
- W4313430106 date "2022-05-01" @default.
- W4313430106 modified "2023-09-27" @default.
- W4313430106 title "Nucleotide Receptors Mediate Protection Against Neonatal Sepsis and Meningitis Caused by Alpha-Hemolysin Expressing <i>Escherichia coli</i> K1" @default.
- W4313430106 doi "https://doi.org/10.4049/jimmunol.208.supp.51.02" @default.
- W4313430106 hasPublicationYear "2022" @default.
- W4313430106 type Work @default.
- W4313430106 citedByCount "0" @default.
- W4313430106 crossrefType "journal-article" @default.
- W4313430106 hasAuthorship W4313430106A5007031588 @default.
- W4313430106 hasAuthorship W4313430106A5024971127 @default.
- W4313430106 hasAuthorship W4313430106A5050187189 @default.
- W4313430106 hasAuthorship W4313430106A5066864788 @default.
- W4313430106 hasAuthorship W4313430106A5075350104 @default.
- W4313430106 hasAuthorship W4313430106A5082144037 @default.
- W4313430106 hasConcept C104317684 @default.
- W4313430106 hasConcept C136139683 @default.
- W4313430106 hasConcept C151730666 @default.
- W4313430106 hasConcept C170493617 @default.
- W4313430106 hasConcept C203014093 @default.
- W4313430106 hasConcept C2777209026 @default.
- W4313430106 hasConcept C2778384902 @default.
- W4313430106 hasConcept C2779343474 @default.
- W4313430106 hasConcept C2781090273 @default.
- W4313430106 hasConcept C54355233 @default.
- W4313430106 hasConcept C547475151 @default.
- W4313430106 hasConcept C60987743 @default.
- W4313430106 hasConcept C86803240 @default.
- W4313430106 hasConcept C89423630 @default.
- W4313430106 hasConceptScore W4313430106C104317684 @default.
- W4313430106 hasConceptScore W4313430106C136139683 @default.
- W4313430106 hasConceptScore W4313430106C151730666 @default.
- W4313430106 hasConceptScore W4313430106C170493617 @default.
- W4313430106 hasConceptScore W4313430106C203014093 @default.
- W4313430106 hasConceptScore W4313430106C2777209026 @default.
- W4313430106 hasConceptScore W4313430106C2778384902 @default.
- W4313430106 hasConceptScore W4313430106C2779343474 @default.
- W4313430106 hasConceptScore W4313430106C2781090273 @default.
- W4313430106 hasConceptScore W4313430106C54355233 @default.
- W4313430106 hasConceptScore W4313430106C547475151 @default.
- W4313430106 hasConceptScore W4313430106C60987743 @default.
- W4313430106 hasConceptScore W4313430106C86803240 @default.
- W4313430106 hasConceptScore W4313430106C89423630 @default.
- W4313430106 hasIssue "1_Supplement" @default.
- W4313430106 hasLocation W43134301061 @default.
- W4313430106 hasOpenAccess W4313430106 @default.
- W4313430106 hasPrimaryLocation W43134301061 @default.
- W4313430106 hasRelatedWork W2087887478 @default.
- W4313430106 hasRelatedWork W2089162011 @default.
- W4313430106 hasRelatedWork W2135935394 @default.
- W4313430106 hasRelatedWork W2143960836 @default.
- W4313430106 hasRelatedWork W2164219735 @default.
- W4313430106 hasRelatedWork W2203082333 @default.
- W4313430106 hasRelatedWork W2316360335 @default.
- W4313430106 hasRelatedWork W2407564995 @default.
- W4313430106 hasRelatedWork W2883108589 @default.
- W4313430106 hasRelatedWork W2288517429 @default.
- W4313430106 hasVolume "208" @default.
- W4313430106 isParatext "false" @default.
- W4313430106 isRetracted "false" @default.
- W4313430106 workType "article" @default.