Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313430141> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4313430141 endingPage "175.24" @default.
- W4313430141 startingPage "175.24" @default.
- W4313430141 abstract "Abstract Monocytes differentiate into CD206+CD301+ reparative macrophages (MΦs) that orchestrate tissue repair in response to damage signals and cytokines. Yet, transplanting allogeneic materials produces a novel situation where innate allorecognition of mismatched MHCI may disrupt normal MΦ responses. B6 monocyte paired immunoglobulin-like receptor (PIR)-A3 recognizes BALB/c H2-Dd to generate pro-inflammatory dendritic cells that promote kidney and heart transplant rejection. Conversely, monocyte PIR-B binding to self MHCI negatively regulates PIR-A signals. How PIRs shape MΦ differentiation after Tx was not understood, so we tested the hypothesis that recognition of self-versus-allogeneic MHCI by PIRs divergently modulates MΦ differentiation. Monocyte-derived MΦ differentiation in wild type (WT), Rag2−/−γc−/−, Pira−/− and Pirb−/− B6 mice was assessed by flow cytometry 3 days after exposure to 20×106 radiation-damaged BALB/c allogeneic (allo) or B6 syngeneic (syn) splenocytes administered intraperitoneally. Syn materials predominantly stimulated monocyte differentiation into phenotypically reparative MΦs. Allo cells instead transformed monocytes exclusively into pro-inflammatory Ly6chiCD86hi MΦs. Rag2−/−γc−/− mice behaved similarly. IL-33 released from injured cells metabolically reprograms infiltrating monocytes and MΦs to support their differentiation into CD206+CD301+MΦs. Interestingly, Pirb−/− mice display greatly reduced C206+CD301+MΦs, which correlated with their decreased expression of the IL-33 receptor. Our data provide important insights into how innate allorecognition by PIR-A disrupts the typical generation of reparative MΦs in response to injured self that is supported by PIR-B. Supported by 5T32AI074490-14" @default.
- W4313430141 created "2023-01-06" @default.
- W4313430141 creator A5010421170 @default.
- W4313430141 creator A5014611876 @default.
- W4313430141 creator A5025921392 @default.
- W4313430141 creator A5037301176 @default.
- W4313430141 creator A5073466889 @default.
- W4313430141 creator A5082355064 @default.
- W4313430141 creator A5088600292 @default.
- W4313430141 date "2022-05-01" @default.
- W4313430141 modified "2023-10-16" @default.
- W4313430141 title "Paired Immunoglobulin-Like Receptors Impact The Differentiation of Reparative Macrophages Following Allogeneic Challenge" @default.
- W4313430141 doi "https://doi.org/10.4049/jimmunol.208.supp.175.24" @default.
- W4313430141 hasPublicationYear "2022" @default.
- W4313430141 type Work @default.
- W4313430141 citedByCount "0" @default.
- W4313430141 crossrefType "journal-article" @default.
- W4313430141 hasAuthorship W4313430141A5010421170 @default.
- W4313430141 hasAuthorship W4313430141A5014611876 @default.
- W4313430141 hasAuthorship W4313430141A5025921392 @default.
- W4313430141 hasAuthorship W4313430141A5037301176 @default.
- W4313430141 hasAuthorship W4313430141A5073466889 @default.
- W4313430141 hasAuthorship W4313430141A5082355064 @default.
- W4313430141 hasAuthorship W4313430141A5088600292 @default.
- W4313430141 hasConcept C104317684 @default.
- W4313430141 hasConcept C148738053 @default.
- W4313430141 hasConcept C159654299 @default.
- W4313430141 hasConcept C170493617 @default.
- W4313430141 hasConcept C189976730 @default.
- W4313430141 hasConcept C200315206 @default.
- W4313430141 hasConcept C203014093 @default.
- W4313430141 hasConcept C2776090121 @default.
- W4313430141 hasConcept C2781184567 @default.
- W4313430141 hasConcept C553184892 @default.
- W4313430141 hasConcept C55493867 @default.
- W4313430141 hasConcept C86803240 @default.
- W4313430141 hasConcept C8891405 @default.
- W4313430141 hasConcept C95444343 @default.
- W4313430141 hasConceptScore W4313430141C104317684 @default.
- W4313430141 hasConceptScore W4313430141C148738053 @default.
- W4313430141 hasConceptScore W4313430141C159654299 @default.
- W4313430141 hasConceptScore W4313430141C170493617 @default.
- W4313430141 hasConceptScore W4313430141C189976730 @default.
- W4313430141 hasConceptScore W4313430141C200315206 @default.
- W4313430141 hasConceptScore W4313430141C203014093 @default.
- W4313430141 hasConceptScore W4313430141C2776090121 @default.
- W4313430141 hasConceptScore W4313430141C2781184567 @default.
- W4313430141 hasConceptScore W4313430141C553184892 @default.
- W4313430141 hasConceptScore W4313430141C55493867 @default.
- W4313430141 hasConceptScore W4313430141C86803240 @default.
- W4313430141 hasConceptScore W4313430141C8891405 @default.
- W4313430141 hasConceptScore W4313430141C95444343 @default.
- W4313430141 hasIssue "1_Supplement" @default.
- W4313430141 hasLocation W43134301411 @default.
- W4313430141 hasOpenAccess W4313430141 @default.
- W4313430141 hasPrimaryLocation W43134301411 @default.
- W4313430141 hasRelatedWork W1575058572 @default.
- W4313430141 hasRelatedWork W2005194145 @default.
- W4313430141 hasRelatedWork W2007900655 @default.
- W4313430141 hasRelatedWork W2023363495 @default.
- W4313430141 hasRelatedWork W2044283553 @default.
- W4313430141 hasRelatedWork W2085796023 @default.
- W4313430141 hasRelatedWork W2375416842 @default.
- W4313430141 hasRelatedWork W2753963021 @default.
- W4313430141 hasRelatedWork W3217425215 @default.
- W4313430141 hasRelatedWork W4313430141 @default.
- W4313430141 hasVolume "208" @default.
- W4313430141 isParatext "false" @default.
- W4313430141 isRetracted "false" @default.
- W4313430141 workType "article" @default.